Scrambling of quantum information can be conveniently quantified by so called out-of-time-order-correlators (OTOC's), i.e. correlators of the type W † τ V † Wτ V , whose measurements presents a formidable experimental challenge. Here we report on a method for the measurement of OTOC's based on the so-called two-point measurements scheme developed in the field of non-equilibrium quantum thermodynamics. The scheme is of broader applicability than methods employed in current experiments and also provides a clear-cut interpretation of quantum information scrambling in terms of non-equilibrium fluctuations of thermodynamic quantities such as work. Furthermore, we provide a numerical example on a spin chain which highlights the utility of our thermodynamic approach when understanding the differences between integrable and ergodic behavior. We also discuss connections to some recent experiments.