Absence of genotoxicity of purified Aloe vera whole leaf dry juice as assessed by an in vitro mouse lymphoma tk assay and an in vivo comet assay in male F344 rats

Abstract

Graphical abstract

Lack of genotoxicity of rhubarb (rhizome) in the Ames and micronucleus in vitro tests

“…Genotoxicity experiments have recently been published on purified Aloe vera whole leaf dry juice assessed by mouse lymphoma tk assay and an in vivo comet assay in male F344 rats [12] , and a mixture of aloin A and B in a commercial aloe gel beverage, which confirmed the absence of genotoxicity of these preparations [13] .…”

Aloe arborescens: In Vitro Screening of Genotoxicity, Effective Inhibition of Enzyme Characteristics for Disease Etiology, and Microbiological Activity

“…This effect was not observed when low anthraquinone Aloe preparations were used [ 37 ]. Moreover, the results obtained by Hu et al showed that purified Aloe vera whole leaf dry juice showed no toxicity to the colon and kidney after oral administration [ 38 ]. The literature data are mainly related to A. vera , while information on A. arborescens is limited.…”

Lack of in vivo genotoxic effect of dried whole Aloe ferox juice

“…The hyperplastic changes and mucosal hyperplasia observed after long-term administration of Aloe vera non-decolourised whole leaf extract, whole leaf powder of Aloe arborescens Miller var. natalensis Berger or emodin in mice and rats may be attributed to an epigenetic effect of the material under investigation [ [9] , [10] , [11] , [12] , [13] , [14] ].…”