Absence of Graying of Pinnal Hairs

Thomas, Jayakar

doi:10.1001/archderm.1989.01670230131032

Cited by 2 publications

(1 citation statement)

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“…The authors suggested the possibility of a Y-linked ethnic trait that may have a control on the retention of pigment. [43] Extensive research in the field of premature graying of hair is underway at the molecular level. Bmpr2, a known receptor for bone morphogenetic proteins (Bmps), and Acvr2a, a known receptor for Bmps and activins, are individually redundant but together essential for multiple follicular traits.…”

Section: Pathogenesis Of Canities Pathogenesis Of Canitiesmentioning

confidence: 99%

Premature graying of hair

Pandhi¹,

Khanna²

2013

Indian J Dermatol Venereol Leprol

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Premature graying is an important cause of low self-esteem, often interfering with socio-cultural adjustment. The onset and progression of graying or canities correlate very closely with chronological aging, and occur in varying degrees in all individuals eventually, regardless of gender or race. Premature canities may occur alone as an autosomal dominant condition or in association with various autoimmune or premature aging syndromes. It needs to be differentiated from various genetic hypomelanotic hair disorders. Reduction in melanogenically active melanocytes in the hair bulb of gray anagen hair follicles with resultant pigment loss is central to the pathogenesis of graying. Defective melanosomal transfers to cortical keratinocytes and melanin incontinence due to melanocyte degeneration are also believed to contribute to this. The white color of canities is an optical effect; the reflection of incident light masks the intrinsic pale yellow color of hair keratin. Full range of color from normal to white can be seen both along individual hair and from hair to hair, and admixture of pigmented and white hair is believed to give the appearance of gray. Graying of hair is usually progressive and permanent, but there are occasional reports of spontaneous repigmentation of gray hair. Studies evaluating the association of canities with osteopenia and cardiovascular disease have revealed mixed results. Despite the extensive molecular research being carried out to understand the pathogenesis of canities, there is paucity of effective evidence-based treatment options. Reports of repigmentation of previously white hair following certain inflammatory processes and use of drugs have suggested the possibility of cytokine-induced recruitment of outer sheath melanocytes to the hair bulb and rekindled the hope for finding an effective drug for treatment of premature canities. In the end, camouflage techniques using hair colorants are outlined.

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Section: Pathogenesis Of Canities Pathogenesis Of Canitiesmentioning

confidence: 99%

Premature graying of hair

Pandhi¹,

Khanna²

2013

Indian J Dermatol Venereol Leprol

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The Pinnal Hair Sign

Thomas¹

1991

Arch Dermatol

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Comment.-Pruritic urticarial plaques and papules of pregnancy is a distinct rash of pregnancy that typically oc¬ curs in the later part of the third trimester in primigrávi¬ das. The rash frequently begins in the abdominal striae as small erythematous papules that coalesce into plaques. The rash often spreads to thighs, buttocks, and extremities, and is intensely pruritic. Most patients obtain symptomatic re¬ lief from topical steroids and antihistamines.Possible hormonal mechanisms have been proposed and investigated but studies of human chorionic gonadotropin levels,2 estradiol, and cortisol have all been unrewarding.3 In those cases in which direct and indirect immunofluorescence have been investigated,4 autoantibodies examined,3 or HLA associations sought,5 results have been unrevealing. It

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Absence of Graying of Pinnal Hairs

Cited by 2 publications

References 0 publications

Premature graying of hair

Premature graying of hair

The Pinnal Hair Sign

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