Absence of Helicobacter pylori infection in coronary atherosclerosis disease in Northeast of Iran

A Comprehensive Survey of the Relationship between Helicobacter pylori Infection and Atherosclerosis in the Iranian Population: A Systematic Review and Meta-analysis

“…In addition, the mean age in the case and control groups was 62.7% and 57.4%, respectively. 22,52,59,60 In four studies, the association between atherosclerosis and H.…”

“…In several studies, this relationship was 0-80%. 22,53 However, none of the selected studies examined the association between eradication of H. pylori infection (or cagA gene status) and atherosclerosis. We entered data from 1242 cases in the current metaanalysis; OR is more reliable than relative risk (RR) for predicting risk factors and clinical outcomes, especially in low sample size studies such as the present study.…”

“…19,20 Recent studies have shown that H. pylori is also isolated from dental plaques, human saliva, duodenum, feces and atherosclerotic plaques, and is strongly associated with the extragastrointestinal disorders such as idiopathic thrombocytopenic purpura, neurological disorders (stroke events), psychiatric, gynecological, pre-eclampsia, infertility, glaucoma, dermatologic complications, lung cancer, iron deficiency anemia, autoimmune diseases, and atherosclerosis. [21][22][23][24][25][26][27][28][29][30][31][32][33] Unfortunately, the rate of colonization with H. pylori is high worldwide, especially in Asia (from 25%-50% in developed countries to 90% in developing countries); the eradication of H. pylori infection has decreased in recent years due to problems such as elimination of antibiotics in acidic gastric conditions, bacterial infiltration under the gastric mucosa, and antibiotic resistance. [34][35][36] According to studies, the rate of gastric cancer in Asia is higher than Western countries, and many researchers attribute this to the high colonization with H. pylori in this geographical area.…”

A Systematic Review and Meta-Analysis on the Relation Between Helicobacter Pylori Infection and Atherosclerosis in the Iranian Population

“…According to the available evidence, the most prominent stimulants for the formation and development of the atherosclerotic plaques are processes of vascular endothelium damage (especially the intima) and the chronic in ammation [60][61][62]. Infectious agents, especially Chlamydia pneumoniae, Mycobacterium tuberculosis and Helicobacter pylori, are among the most important infections that can cause chronic in ammation to escape the immune system and appear to be involved in the formation of the atherosclerotic plaques [20]. The hypothesis of the role of Helicobacter pylori infection and atherosclerosis was rst reported by Menall et al and the track of Helicobacter pylori infection has been observed in atherosclerotic plaques of coronary, carotid and aortic arteries [38,63].…”

“…Recent studies have shown that H. pylori is also isolated from dental plaques, human saliva, duodenum, feces and atherosclerotic plaques and is strongly related with the extra-gastrointestinal disorders such as idiopathic thrombocytopenic purpurae, neurological disorders (stroke events), psychiatric, gynecological, pre-Eclampsia, infertility, glaucoma, dermatologic complications, lung cancer, iron de ciency anemia, and atherosclerosis [19][20][21][22][23][24][25][26][27][28][29][30]. Unfortunately, the rate of colonization with H. pylori is high worldwide, especially in Asia (from 25-50% in the developed countries to 90% in the developing countries), and despite the eradication of H. pylori infection due to the destruction of antibiotics in acidic stomach conditions, the in uence of the bacterium under the gastric mucus and the antibiotic resistance has been reduced in the recent years [31][32][33].…”