Absence of human papillomavirus in esophageal carcinomas from southwestern Kenya

White, Russell E.; Mungatana, Caesar; Mutuma, Geoffrey; Robert, Marie E.; Daniel, Richard; Topazian, Mark D.; Shah, Keerti V.

doi:10.1111/j.1442-2050.2005.00452.x

Cited by 20 publications

(13 citation statements)

References 28 publications

(47 reference statements)

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“…Using a highly sensitive assay for high-risk HPV, we failed to detect any HPV sequences in the 28 cases tested. These results support the conclusions of a previous analysis performed on 29 biopsies of ESCC collected in the Bomet District, Western Kenya [37]. …”

Section: Discussionsupporting

confidence: 92%

TP53 mutations, human papilloma virus DNA and inflammation markers in esophageal squamous cell carcinoma from the Rift Valley, a high-incidence area in Kenya

et al. 2011

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BackgroundSquamous Cell Carcinoma of Esophagus is one of the most common malignancies in both men and women in eastern and south-eastern Africa. In Kenya, clinical observations suggest that this cancer is frequent in the Rift Valley area. However, so far, there has been no report on the molecular characteristics of esophageal squamous cell carcinoma (ESCC) in this area.ResultsWe have analyzed TP53 mutations, the presence of human papilloma virus (HPV) DNA and expression of inflammation markers Cyclooxygenase 2 (Cox-2) and Nitrotyrosine (NTyR) in 28 cases (13 males and 15 females) of archived ESCC tissues collected at the Moi Teaching and Referral Hospital in Eldoret, Kenya. Eleven mutations were detected in TP53 exons 5 to 8 (39%). All ESCC samples were negative for HPV 16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68, 70, 73 and 82. Immunohistochemical analysis of Cox-2 and NTyR showed a low proportion of positive cases (17.4% and 39.1%, respectively). No association between the above markers and suspected risk factors (alcohol or tobacco use, hot tea drinking, use of charcoal for cooking) was found.ConclusionOur findings suggest that mechanisms of esophageal carcinogenesis in eastern Africa might be different from other parts of the world. Low prevalence of TP53 mutation compared with other intermediate or high incidence areas of the world highlights this hypothesis. Our data did not support a possible ole of HPV in this series of cases. Further studies are needed to assess and compare the molecular patterns of ESCC from Kenya with those of high-incidence areas such as China or Central Asia.

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Section: Discussionsupporting

confidence: 92%

TP53 mutations, human papilloma virus DNA and inflammation markers in esophageal squamous cell carcinoma from the Rift Valley, a high-incidence area in Kenya

et al. 2011

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“…However, counterarguments have been suggested, including the lack of association between OSCC and immunosuppression or previous HPV-associated disease (Gillison and Shah, 2003) and wide variability in case-series report of HPV positivity in OSCC cases (Syrjanen, 2002) – ranging worldwide from over 70% positivity (Liu et al , 2000; Cao et al , 2005; Zhu et al , 2005; Yang et al , 2008; Ding et al , 2009; Qu et al , 2012) to 0% (Hale et al , 1989; Loke et al , 1990; Benamouzig et al , 1995; Smits et al , 1995; Saegusa, 1997; Morgan et al , 1997; Kamath et al , 2000; Talamini et al , 2000; Awerkiew et al , 2003; White et al , 2005; Koh et al , 2008; Bellizzi et al , 2009; Song et al , 2009; Patel et al , 2011; Noori et al , 2012; Haeri et al , 2013). Even within countries, the prevalence of HPV varies widely.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of human papillomavirus among oesophageal squamous cell carcinoma cases: systematic review and meta-analysis

et al. 2014

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Background:Oncogenic human papillomavirus (HPV) has been hypothesised as a risk factor for oesophageal squamous cell carcinoma (OSCC), but aetiological research has been limited by the varying methodology used for establishing HPV prevalence. The aims of this systematic review and meta-analysis were to estimate the prevalence of HPV DNA detected in OSCC tumours and the influence of study characteristics.Methods:Study-level estimates of overall and type-specific HPV prevalence were meta-analysed to obtain random-effects summary estimates.Results:This analysis included 124 studies with a total of 13 832 OSCC cases. The average HPV prevalence (95% confidence interval) among OSCC cases was 0.277 (0.234, 0.320) by polymerase chain reaction; 0.243 (0.159, 0.326) by in situ hybridisation; 0.304 (0.185, 0.423) by immunohistochemistry; 0.322 (0.154, 0.490) by L1 serology; and 0.176 (0.061, 0.292) by Southern/slot/dot blot. The highest HPV prevalence was found in Africa and Asia, notably among Chinese studies from provinces with high OSCC incidence rates.Conclusions:Future research should focus on quantifying HPV in OSCC cases using strict quality control measures, as well as determining the association between HPV and OSCC incidence by conducting large, population-based case–control studies. Such studies will provide a richer understanding of the role of HPV in OSCC aetiology.

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“…15,17,21). In populations with higher ESCC incidence rates, reports of HPV prevalence in tumor tissues have ranged from 0% in Kenya and Linxian Province in China (18,35), to 54%, 65%, and 72% in Egyptian, Gansu (China), and Anyang (China) populations, respectively (15,36,37).…”

Section: Discussionmentioning

confidence: 99%

High-Risk Human Papillomavirus in Esophageal Squamous Cell Carcinoma

Antonsson

Nancarrow

Brown

et al. 2010

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Although most cases of esophageal squamous cell carcinoma (ESCC) in western populations have been attributed to high levels of exposure to tobacco and alcohol, infectious agents have been postulated as possible causes, particularly human papillomavirus (HPV).Methods: To explore this issue, we analyzed HPV DNA prevalence and HPV types together with lifestyle factors, in relation to tumor stage and survival in a low-incidence population. Archived tumor samples from a nationwide cohort of 222 ESCC patients were tested for the presence of HPV DNA by PCR; positive samples were sequenced to determine HPV type, and p16INK4a status was assessed by immunohistochemistry.

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Absence of human papillomavirus in esophageal carcinomas from southwestern Kenya

Cited by 20 publications

References 28 publications

TP53 mutations, human papilloma virus DNA and inflammation markers in esophageal squamous cell carcinoma from the Rift Valley, a high-incidence area in Kenya

TP53 mutations, human papilloma virus DNA and inflammation markers in esophageal squamous cell carcinoma from the Rift Valley, a high-incidence area in Kenya

Prevalence of human papillomavirus among oesophageal squamous cell carcinoma cases: systematic review and meta-analysis

High-Risk Human Papillomavirus in Esophageal Squamous Cell Carcinoma

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