Absence of Human Papillomavirus in Benign and Malignant Breast Tissue

Aghdam, Maryam Kazemi; Nadji, Seyed Alireza; Alvandimanesh, Azadeh; Maliheh, Maliheh; Khademi, Yassaman

doi:10.30699/ijp.2019.89684.1847

Cited by 3 publications

(2 citation statements)

References 28 publications

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“…The current meta-analysis confirms the wide variations existing among the included studies. Various reasons have been described for the aforementioned discrepancy, which not only affects the possibility of an association of HPV with BC, but also the distribution of the HPV genotypes: Geographic region(s) of the samples, genetic background, cultural variations such as variable sexual practices and patterns, sample types such as fresh versus FFPE samples, age of the selected populations, sensitivity of the detection methods used, condition of the preserved samples that can hamper DNA quality, the histological type of BCs (IDC versus ductal adenocarcinoma in situ), the absence of an international standard assay for HPV genotyping and the unintentional contamination of samples with the genome of other potentially oncogenic viruses, such as EBV, MMTV, CMV and HSV (2,4,7,13,31,(94)(95)(96)(97)(98).…”

Section: Discussionmentioning

confidence: 99%

“…Viral etiology of breast carcinoma has been addressed in numerous studies, but still remains controversial ( 9 ). Several viruses, including bovine leukemia virus, Kaposi's sarcoma-associated herpesvirus, Epstein-Barr virus (EBV), mouse mammary tumor virus (MMTV), simian vacuolating virus 40 ( 10 ), human mammary tumor virus ( 11 ), cytomegalovirus (CMV) ( 12 ), herpes simplex virus-1 (HSV), human herpes virus type-8 ( 13 ) have been regarded as potential breast oncogenic factors a number of years ago. In 1944, the discovery that MMTV caused BC in mice led researchers to investigate a possible viral contribution to BC ( 14 ).…”

Section: Introductionmentioning

confidence: 99%

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Human papillomaviruses and breast cancer: A systematic review and meta‑analysis

Karachalios,

Petousis,

Margioula‑Siarkou

et al. 2023

Oncol Lett

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Breast cancer (BC) is the leading malignancy worldwide. The association between human papillomavirus (HPV) and BC is debatable. The present systematic review and meta-analysis aimed to assess the prevalence of HPV DNA in malignant breast tumors. An extensive search of the PubMed and SCOPUS databases was carried out for case-control studies published between January 1, 2003 and January 7, 2023, which compared HPV DNA detection in breast tissue specimens of female patients with BC and women with absent or benign breast disorders. Once the initial title/abstract screening was completed by two independent investigators, the full texts of the included studies from that stage were reviewed by the aforementioned investigators to determine if they should be included in the present study. Data extraction was independently conducted by two investigators. A third investigator was consulted to resolve disagreements through free discussion. MedCalc was used for quantitative synthesis. The significance of association was estimated by pooled odds ratios (ORs) with 95% confidence intervals (CIs) calculated using the random-effects model. A total of 23 primary studies, including 3,243 subjects (2,027 patients and 1,216 controls), were eligible for quantitative analysis. HPV prevalence in patients with BC and controls was 21.95 and 8.96%, respectively. The prevalence of HPV differed significantly between the two groups (OR 3.83; 95% CI 2.03-7.25; P<0.01). Heterogeneity among studies was quantified using the I 2 index which was 69.57% (95% CI 51.89-80.75). The risk of bias was assessed using an appropriate tool contributed by the CLARITY Group at McMaster University. Seven studies had a low risk of bias, 15 studies had a moderate risk of bias and only one study had a serious risk of bias. These results reinforce the hypothesis that HPV is involved in BC development and progression, indicating a possible role of HPV vaccination in BC prevention.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Human papillomaviruses and breast cancer: A systematic review and meta‑analysis

Karachalios,

Petousis,

Margioula‑Siarkou

et al. 2023

Oncol Lett

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The prevalence of varicella zoster virus, herpes simplex virus type 2, and human papillomavirus in breast cancerous tissues and their adjacent ones in Iran

Tavakolian,

Faghihloo

2023

Journal of Research in Medical Sciences

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Background: Breast cancer is the second type of cancer in the world. Some internal and external risk factors, especially infection diseases, can progress breast cancer. As the relation between varicella zoster virus (VZV), human papillomavirus (HPV), herpes simplex virus type 2 (HSV-2), and breast cancer has not been understood, it was attempting to find the effect of these viruses and breast cancer in this study. Materials and Methods: We collected 40 breast cancer and 50 healthy adjacent tissues from Taleghani and Imam Hossein Hospital, Tehran, Iran, in 3 years starting in 2017. After extracting DNA from breast tissues, multiplex polymerase chain reaction (PCR), nested PCR, and PCR were done to analyze the prevalence of HSV-2, VZV, and HPV. Results: Our results showed that HPV may be one of the important causes of breast cancer. Nested PCR illustrated nine breast cancerous tissues (mean age: 43) and three healthy adjacent ones (mean age: 41) were infected by HPV. Phylogenetic analysis illustrated that all of the infected HPV cancerous and healthy tissues were HPV 18 (except two healthy samples infected with HPV 6). Nevertheless, there were not any infected tissues by HSV-2 and VZV. Conclusion: It seems that HPV virus type 18 can have high prevalence in breast cancerous tissues in comparison with healthy adjacent ones, and it is likely to have an effect on breast cancer progression. However, the opposite trend is true for HSV-2 and VZV as we did not find any differences between different kinds of breast tissues.

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Human Papilloma Virus Infection in Iranian Women with Breast Cancer: A Systematic Review

Jafari Sales,

Ebrahimzadeh,

Pashazadeh

2024

J Clin Res Paramed Sci

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Background: Breast cancer (BC) is one of the most common cancers and health problems in women under the age of 40. Objectives: This systematic study investigates the presence of human papilloma virus (HPV) in Iranian women with BC by searching various international and Iranian databases using standardized keywords. Methods: The inclusion and exclusion criteria were applied to select 22 articles with a total of 2445 BC samples for data extraction and analysis using Statistical Package for the Social Sciences (SPSS) software. Results: The results show that 21.10% of BC samples were HPV positive with Khuzestan, Shahrekord, Mashhad, and Karaj having the highest number of HPV-positive cases among women with BC. Polymerase chain reaction (PCR) was the most used method for detecting HPV in the studies. The distribution of BC samples was highest in Karaj, Tehran, and Golestan. Conclusions: This study provides valuable information about the prevalence of HPV in Iranian women with BC and the geographical distribution of positive cases.

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Absence of Human Papillomavirus in Benign and Malignant Breast Tissue

Cited by 3 publications

References 28 publications

Human papillomaviruses and breast cancer: A systematic review and meta‑analysis

Human papillomaviruses and breast cancer: A systematic review and meta‑analysis

The prevalence of varicella zoster virus, herpes simplex virus type 2, and human papillomavirus in breast cancerous tissues and their adjacent ones in Iran

Human Papilloma Virus Infection in Iranian Women with Breast Cancer: A Systematic Review

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