Absence of<i>Helicobacter pylori</i>in healthy laryngeal mucosa

Pajić-Penavić, Ivana; Đanić, Davorin; Maslovara, Siniša; Gall-Trošelj, Koraljka

doi:10.1017/s0022215111002799

Cited by 9 publications

(7 citation statements)

References 19 publications

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“…The H. pylori infection identified by nested PCR was significant in both univariate and multivariate analysis comparing with control subjects (Tables and ), indicating that H. pylori might be a risk factor for vocal fold leukoplakia. Literature data revealed that H. pylori was not considered a normal microflora in healthy laryngeal mucosa . A possible pathogenesis of vocal fold leukoplakia has been explained by the inflammation induced by this bacterium leading to epithelial cell proliferation.…”

Section: Discussionmentioning

confidence: 99%

“…Literature data revealed that H. pylori was not considered a normal microflora in healthy laryngeal mucosa. 20 A possible pathogenesis of vocal fold leukoplakia has been explained by the inflammation induced by this bacterium leading to epithelial cell proliferation. The potential for destroying epithelial mucosa and inflammation could cause chronic injury resulting in larynx pathology.…”

Section: Discussionmentioning

confidence: 99%

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Possible association between Helicobacter pylori infection and vocal fold leukoplakia

Chen

Yang

et al. 2018

Head & Neck

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Background Several studies have indicated the larynx as possible Helicobacter pylori (H. pylori) reservoirs. This study explored the association between H. pylori and vocal fold leukoplakia. Methods The case‐control study involved 51 patients with vocal fold leukoplakia and 35 control patients with vocal polyps. Helicobacter pylori was detected in tissues by the rapid urease test, nested polymerase chain reaction (PCR), and single‐step PCR. The H. pylori‐specific immunoglobulin antibodies were detected in plasma by enzyme‐linked immunosorbent assay (ELISA). Results Helicobacter pylori‐positive rate of vocal fold leukoplakia and vocal polyps was 23.5% versus 11.4% (P = .157), 37.2% versus 14.3% (P = .020), 27.5% versus 8.6% (P = .031), and 70.6% versus 68.6% (P = .841) detected by rapid urease test, nested PCR, single‐step PCR, and ELISA, respectively. Regression analysis indicated that H. pylori infection (P = .044) was the independent risk factor for vocal fold leukoplakia. Conclusion Helicobacter pylori infection exists in the larynx and may be associated with vocal fold leukoplakia.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Possible association between Helicobacter pylori infection and vocal fold leukoplakia

Chen

Yang

et al. 2018

Head & Neck

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“…Another controversy concerned the implication of H. pylori infection as a risk factor in laryngeal cancer. Whereas Pajic-Penavic et al [82] did not detect H. pylori DNA in healthy laryngeal mucosa, Izadi et al [83] identified H. pylori DNA in 9% (5/55) patients with benign laryngeal lesions. Then Gong et al [84] compared H. pylori DNA detection between 81 patients with laryngeal squamous cell carcinoma and 75 control subjects in a case-control study.…”

Section: Eye Ear Nose and Throat Disordersmentioning

confidence: 97%

“…Whereas Pajic‐Penavic et al. did not detect H. pylori DNA in healthy laryngeal mucosa, Izadi et al. identified H. pylori DNA in 9% (5/55) patients with benign laryngeal lesions.…”

Section: Eye Ear Nose and Throat Disordersmentioning

confidence: 98%

Extragastric Diseases and Helicobacter pylori

et al. 2013

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In the last year, several diseases from outside of the gastrointestinal tract have been associated with Helicobacter pylori infection. Indeed, this bacterium produces a low-grade inflammatory state, induces molecular mimicry mechanisms, and interferes with the absorbance of nutrients and drugs possibly influencing the occurrence or the evolution of many diseases. In addition to its role in some hematologic conditions, such as immune thrombocytopenic purpura, idiopathic sideropenic anemia, and vitamin B12 deficiency, which were included in the current guidelines, several other conditions such as cardiovascular diseases, diabetes mellitus, hepatobiliary diseases, and neurologic disorders have also shown promising results.

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“…The effect of H. pylori in different benign laryngeal diseases is under investigation, but the data in this field are still limited. Available data show that H. pylori cannot be considered as a member of the normal laryngeal flora, and recent studies are intended to reveal the role of H. pylori in laryngeal diseases [2,29] .…”

Section: Role Of Helicobacter Pylori In Benign Laryngeal Lesionsmentioning

confidence: 99%

Association between Helicobacter pylori and Pharyngolaryngeal Carcinomas: The Role in the Development and Prognostic Significance

Bayındır¹,

Bayındır²,

Koca³

et al. 2019

mjima

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Helicobacter pylori dünyada yaygın olarak bulunan ve insanları enfekte eden bir bakteridir. Bu Gram-olumsuz mikroorganizma, mikroaerofilik, spiral ya da eğimli şekildedir ve ayrıca üreaz, katalaz ve oksidaz olumludur. Midedeki asidik ortamda yaşamını sürdürme özelliğine sahiptir. Günümüzde H. pylori'nin gastrik ülser ve malign lezyonlarda rolü olduğu ispatlanmıştır. Dahası, H. pylori'nin kardiyovasküler, dermatolojik, immünolojik, nörolojik, hematolojik, oftalmolojik, jinekolojik, endokrinolojik ve hepatobiliyer hastalıklar gibi çeşitli sistemik hastalıkların nedeni olabileceği bildirilmiştir. Ayrıca literatürde H. pylori enfeksiyonu ile rinit, sinüzit, adenoidit/adenoid hipertrofi, otitis media, tonsillit/tonsil hipertrofisi gibi benign üst solunum yolu hastalıkları arasında olumlu ya da olumsuz ilişki gösteren çok sayıda çalışma bulunmaktadır. Ancak H. pylori'nin patogenezdeki rolü veya bu hastalıklarla olan ilişkisi ile ilgili tartışmalar devam etmektedir. Bununla birlikte bazı çalışmalarda H. pylori'ye karşı oluşan sistemik immün ya da enflamatuvar yanıtın bazı sistemik hastalıkların veya malignitelerin nedeni olabileceği bildirilmiştir. Her ne kadar H. pylori'nin üst ve alt solunum yolu benign ve malign hastalıklarındaki rolü hakkında çalışmalar bulunsa da, H. pylori enfeksiyonu ve solunum yolu hastalıkları arasındaki patofizyolojik ilişkiyi ortaya koymak için daha ileri çalışmalara gereksinim bulunmaktadır. Bu derleme ile literatürde H. pylori ve solunum yollarının hem benign hem de malign hastalıkları arasındaki hem olumlu hem de olumsuz ilişkiyi gösteren çalışmaların özetlenmesi hedeflendi.

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Absence ofHelicobacter pyloriin healthy laryngeal mucosa

Abstract: Based on these results, we do not consider Helicobacter pylori to be a normal constituent of healthy laryngeal microflora.

Cited by 9 publications

References 19 publications

Possible association between Helicobacter pylori infection and vocal fold leukoplakia

Possible association between Helicobacter pylori infection and vocal fold leukoplakia

Extragastric Diseases and Helicobacter pylori

Association between Helicobacter pylori and Pharyngolaryngeal Carcinomas: The Role in the Development and Prognostic Significance

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