Absence of Interhuman Transmission of Hantavirus Pulmonary Syndrome in Minas Gerais, Brazil: Evidence from a Serological Survey

Nunes-Araújo, F. Regina F.; Nishioka, Sérgio de Andrade; Ferreira, Ivani B.; Suzuki, Akemi; Bonito, Rosuíta Frattari; Ferreira, Marcelo Simão

doi:10.1086/313547

Cited by 4 publications

(2 citation statements)

References 6 publications

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“…A cross-species transmission event may result in infection, and possibly in disease, in an exposed individual, but transmission of the virus between members of the new species does not necessarily occur. For example, human diseases caused by viruses such as Sin Nombre (Bunyaviridae) and Nipah (Paramyxoviridae) viruses result from exposure to infected reservoir species but infected humans do not transmit the virus effectively to other humans (10,27,29,32,33). In contrast, human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2, respectively), which derive from simian immunodeficiency viruses (13,15) (all lentiviruses in the family Retroviridae), are readily transmitted from human to human and are effectively maintained in the human population.…”

mentioning

confidence: 99%

Feline Lentivirus Evolution in Cross-Species Infection Reveals Extensive G-to-A Mutation and Selection on Key Residues in the Viral Polymerase

Poss

Ross

Painter³

et al. 2006

J Virol

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Factors that restrict a virus from establishing productive infection in a new host species are important to understand because cross-species transmission events are often associated with emergent viral diseases. To determine the evolutionary pressures on viruses in new host species, we evaluated the molecular evolution of a feline immunodeficiency virus derived from a wild cougar, Puma concolor, during infection of domestic cats. Analyses were based on the coding portion of genome sequences recovered at intervals over 37 weeks of infection of six cats inoculated by either intravenous or oral-nasal routes. All cats inoculated intravenously, but only one inoculated orally-nasally, became persistently viremic. There were notable accumulations of lethal errors and predominance of G-to-A alterations throughout the genome, which were marked in the viral polymerase gene, pol. Viral structural (env and gag) and accessory (vif and orfA) genes evolved neutrally or were under purifying selection. However, sites under positive selection were identified in reverse transcriptase that involved residues in the nucleotide binding pocket or those contacting the RNA-DNA duplex. The findings of extensive G-to-A alterations in this cross-species infection are consistent with the recently described editing of host cytidine deaminase on lentivirus genomes. Additionally, we demonstrate that the primary site of hypermutation is the viral pol gene and the dominant selective force acting on this feline immunodeficiency virus as it replicates in a new host species is on key residues of the virus polymerase.

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confidence: 99%

Feline Lentivirus Evolution in Cross-Species Infection Reveals Extensive G-to-A Mutation and Selection on Key Residues in the Viral Polymerase

Poss

Ross

Painter³

et al. 2006

J Virol

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“…In Brazil, the first reported HPS cases occurred in 1993 in the southeast, caused by JUQV, and in this small outbreak, 66% of the patients had a fatal outcome (439). Person-toperson transmission has not been observed (310). From 1993 through April 2009, 1,145 HPS cases were reported in Brazil, with a 39.5% case fatality rate, and were caused mostly by five lineages of hantavirus: Araucária strain, Araraquara, LANVlike, Castelo dos Sonhos, and Anajatuba viruses (44a, 180, 276).…”

Section: Epidemiology Of New World Hantavirusesmentioning

confidence: 99%

A Global Perspective on Hantavirus Ecology, Epidemiology, and Disease

2010

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SUMMARY Hantaviruses are enzootic viruses that maintain persistent infections in their rodent hosts without apparent disease symptoms. The spillover of these viruses to humans can lead to one of two serious illnesses, hantavirus pulmonary syndrome and hemorrhagic fever with renal syndrome. In recent years, there has been an improved understanding of the epidemiology, pathogenesis, and natural history of these viruses following an increase in the number of outbreaks in the Americas. In this review, current concepts regarding the ecology of and disease associated with these serious human pathogens are presented. Priorities for future research suggest an integration of the ecology and evolution of these and other host-virus ecosystems through modeling and hypothesis-driven research with the risk of emergence, host switching/spillover, and disease transmission to humans.

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Hantavirus pulmonary syndrome: at the crossroads

Khan

Young²

2001

Current Opinion in Infectious Diseases

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The initial identification in 1993 of hantavirus pulmonary syndrome as a novel, highly fatal respiratory illness among American Indians in the southwestern USA in 1993 opened the window to the recognition of a well-established pan-American zoonosis with a myriad of causative viruses and rodent vectors, although all are New World hantaviruses among New World sigmodontine rodents. The clinical spectrum of symptoms has also been expanded to include asymptomatic infection through to fulminant hemorrhagic fever. Although the use of ribavirin, an antiviral drug, was disappointing in an early, open-labeled trial, early detection and supportive care is much better refined. However, much work remains in probing the pathogenesis of this syndrome to help define and explore therapeutic options and the mechanism of person-to-person transmission with Andes virus, one of the viruses that cause hantavirus pulmonary syndrome. Current remote sensing efforts and longitudinal ecologic investigations need to be expanded in order to focus prevention efforts better.

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Absence of Interhuman Transmission of Hantavirus Pulmonary Syndrome in Minas Gerais, Brazil: Evidence from a Serological Survey

Cited by 4 publications

References 6 publications

Feline Lentivirus Evolution in Cross-Species Infection Reveals Extensive G-to-A Mutation and Selection on Key Residues in the Viral Polymerase

Feline Lentivirus Evolution in Cross-Species Infection Reveals Extensive G-to-A Mutation and Selection on Key Residues in the Viral Polymerase

A Global Perspective on Hantavirus Ecology, Epidemiology, and Disease

Hantavirus pulmonary syndrome: at the crossroads

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