Absence of metallothionein-3 produces changes on MT-1/2 regulation in basal conditions and alters hypothalamic-pituitary–adrenal (HPA) axis

Lago, Natalia; Quintana, Albert; Carrasco, Javier; Giralt, Mercedes; Hidalgo, Juan; Molinero, Amalia

doi:10.1016/j.neuint.2014.06.008

Cited by 2 publications

(2 citation statements)

References 78 publications

(84 reference statements)

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“…MT3 is known to be abundant in the dentate gyrus (DG) [16]. Our study of gene expression in the DG of a population of litter-mate matched mice, presented here, revealed significant differences between tested mice in the expression levels of Mt3 , along with a suite of other genes associated with zinc homeostasis.…”

Section: Introductionmentioning

confidence: 68%

Function of Metallothionein-3 in Neuronal Cells: Do Metal Ions Alter Expression Levels of MT3?

Bousleiman

Pinsky

et al. 2017

IJMS

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A study of factors proposed to affect metallothionein-3 (MT3) function was carried out to elucidate the opaque role MT3 plays in human metalloneurochemistry. Gene expression of Mt2 and Mt3 was examined in tissues extracted from the dentate gyrus of mouse brains and in human neuronal cell cultures. The whole-genome gene expression analysis identified significant variations in the mRNA levels of genes associated with zinc homeostasis, including Mt2 and Mt3. Mt3 was found to be the most differentially expressed gene in the identified groups, pointing to the existence of a factor, not yet identified, that differentially controls Mt3 expression. To examine the expression of the human metallothioneins in neurons, mRNA levels of MT3 and MT2 were compared in BE(2)C and SH-SY5Y cell cultures treated with lead, zinc, cobalt, and lithium. MT2 was highly upregulated by Zn2+ in both cell cultures, while MT3 was not affected, and no other metal had an effect on either MT2 or MT3.

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Section: Introductionmentioning

confidence: 68%

Function of Metallothionein-3 in Neuronal Cells: Do Metal Ions Alter Expression Levels of MT3?

Bousleiman

Pinsky

et al. 2017

IJMS

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“…According to the article: Absence of Metallothionein-3 produces changes in MT-1/2 regulation and the hypothalamic-pituitary-adrenal (HPA) axis [6], additional evidence supporting the potential link between MT-3 and anxiety-like behaviors is provided. This review focuses on the regulation of Metallothionein-1/2 (MT-1/2) and its potential influence on the hypothalamic-pituitary-adrenal (HPA) axis.…”

Section: Literature Reviewmentioning

confidence: 99%

Investigating the role of metallothionein-3 (MT-3) in snxiety-like bBehaviors: An in-depth research proposal

Wang

2024

TNS

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Anxiety is a common mental health disorder that profoundly impacts individuals' daily lives. Metallothionein-3 (MT-3), a protein found in the central nervous system, is hypothesized to play a role in anxiety-like behaviors. This research proposal aims to investigate the induction of anxiety-like behaviors in the presence of MT-3 using an experimental approach. Previous studies have shown that MT-3 deficiency is associated with abnormalities in psychological behaviors. The proposed study will build upon this research to further explore the cellular and molecular mechanisms underlying MT-3 involvement in anxiety. The study will utilize a mouse preclinical model and behavioral assays to assess anxiety-like behaviors in the presence or absence of MT-3. The findings from this research may contribute to the development of novel therapeutic strategies for managing anxiety.

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Absence of metallothionein-3 produces changes on MT-1/2 regulation in basal conditions and alters hypothalamic-pituitary–adrenal (HPA) axis

Cited by 2 publications

References 78 publications

Function of Metallothionein-3 in Neuronal Cells: Do Metal Ions Alter Expression Levels of MT3?

Function of Metallothionein-3 in Neuronal Cells: Do Metal Ions Alter Expression Levels of MT3?

Investigating the role of metallothionein-3 (MT-3) in snxiety-like bBehaviors: An in-depth research proposal

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