Absence of Mucosal Atrophy in Human Small Intestine After Prolonged Isolation

Tompkins, Ronald K.; Waisman, Jerry; Christine, M.; Watt, Bethany; Corlin, Richard F.; Keith, Roger G.

doi:10.1016/s0016-5085(19)31523-9

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Gut Immune Function1

Intestinal Adaptation In Humans1

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Cited by 28 publications

(2 citation statements)

References 7 publications

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“…An apparent derangement of the immunologic surveillance by the intestine had been inferred from studies of experimental animals during parenteral nutrition, as demonstrated by measuring decreased activity and number of intestinal immunologic cells [66,68].…”

Section: Gut Immune Functionmentioning

confidence: 99%

Specific topics and complications of parenteral nutrition

Montalvo-Javé

Zárraga

Sarr

2007

Langenbecks Arch Surg

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Section: Gut Immune Functionmentioning

confidence: 99%

Specific topics and complications of parenteral nutrition

Montalvo-Javé

Zárraga

Sarr

2007

Langenbecks Arch Surg

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“…The bypassed jejunoileum does not share this response unless there is reflux of luminal content into the excluded loop [64]. It generally becomes hypoplastic [65,66] or remains unaltered in structure [67,68].…”

Section: Intestinal Adaptation In Humansmentioning

confidence: 99%

Postoperative adaptation of the small intestine

Bristol

Williamson

1985

World j. surg.

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For nearly 100 years, the small intestine has been known to compensate for partial tissue loss. For only some 20 years has the phenomenon been studied in any depth, and a small proportion of these investigations has been undertaken in humans. Experimental and clinical data show that enteric mucosal hyperplasia in the remaining small bowel after enteric resection or bypass is accompanied by cytokinetic and functional adaptation. In general, the degree of adaptation depends on 3 factors: the amount of tissue excised or excluded, the particular enteric segment involved, and the presence or absence of a normal luminal stream. Thus, massive enterectomy can overwhelm the adaptive capacity of the gut, loss of jejunum is better tolerated than loss of terminal ileum, and total parenteral nutrition will abolish the compensatory response. The mechanisms that govern adaptive change are complex and interrelated. They involve both luminal agents (food, alimentary secretions) and humoral influences, of which enteroglucagon appears to be the most important. Wherever possible, small bowel operations should take account of adaptive phenomena in order to minimize metabolic and nutritional sequelae.

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Dietary Carbohydrate and the Kinetics of Intestinal Functions in Relation to Hexose Absorption

Levin¹

1989

Dietary Starches and Sugars in Man: A Comparison

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Absence of Mucosal Atrophy in Human Small Intestine After Prolonged Isolation

Cited by 28 publications

References 7 publications

Specific topics and complications of parenteral nutrition

Specific topics and complications of parenteral nutrition

Postoperative adaptation of the small intestine

Dietary Carbohydrate and the Kinetics of Intestinal Functions in Relation to Hexose Absorption

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