Absence of occult hepatitis B virus infection in sera of diabetic children and adolescents following hepatitis B vaccination

Elrashidy, Heba; El–Didamony, Gamal; Elbahrawy, Ashraf; Hashim, Ahmed; Alashker, Ahmed; Morsy, Mohamed Hanafy; Elwassief, Ahmed; Elmestikawy, Amr; Abdallah, Abdallah Mahmoud; Mohammad, Abdel-Gawad Saeid; Mostafa, Mohamed; George, Nilly M; Abdelhafeez, Hafez

doi:10.4161/hv.29521

Cited by 15 publications

(10 citation statements)

References 31 publications

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“…[10] Only 8% (n=45/564) of HCWs in our study received infantile HB vaccination. Although the anti-HBc sero-positivity (0-0.36 %) is very low among Egyptian general population who received infantile HB vaccination, [15,21] the anti-HBc was detected in 31 % (n=14/45) of HCWs who received HB vaccination in our study; of them, two (n=2/45) were infected by HBV/E genotype. This data reflected the high HBV exposure risk among HCWs and infer the waning of protective anti-HBs after adolescent age and suggest the need for HB vaccine boosting.…”

Section: Discussionmentioning

confidence: 94%

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Hepatitis B virus genotype E infection among Egyptian health care workers

Elmaghloub

Elbahrawy

Didamony

et al. 2017

Journal of Translational Internal Medicine

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Background and Objectives: Health Care Workers (HCWs) are at a high risk of needle stick injuries and HBV infection in Egypt; this problem is further aggravated by low Hepatitis B (HB) vaccination coverage. Limited data are available on the prevalence of HBV infection in Egyptian HCWs. In this study, we aimed to assess the HBV infection rate and genotypes among Egyptian HCWs. Methods: Five hundred and sixty-four (564) HCWs were included. Of them, 258 (45.74%) were health care providers and 306 (54.25%) were non-health care providers. All HCWs completed both the study questionnaires and provided a blood sample for HBV testing. Indeed, all HCWs were tested for Hepatitis B surface antigen (HBsAg) and antibody to Hepatitis B core antigen (anti-HBc), by enzyme-linked immunosorbent assay. HBVDNA was checked for HCWs who tested positive for HBsAg and/or anti-HBc, by nested Polymerase Chain Reaction (PCR). HBVDNA positive HCWs were further subjected to HBV genotyping. Results: The mean age of included HCWs was 33.0 ± 9.8 years, of whom 319 (56.56%) were males. The mean duration of health care work was 9.3 ± 6.7 years. The frequency of HBsAg and anti-HBc were 1.4%, and 24.5%, respectively. Old age and prolonged duration of health care work were significantly associated with anti-HBc seropositivity. Among 140 HCWs positive for HBsAg and/or anti-HBc, 14 (10 %) had positive HBVDNA by PCR. HBV/E (n = 7), HBV/D (n = 3) and co-infection with E and D (n = 4) genotypes were detected. Conclusion: Egyptian HCWs have a significantly high rate of HBV exposure. The detection of HBV/E genotype among Egyptian HCWs suggests prevalent transmission of HBV/E among Egyptian populations.

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Section: Discussionmentioning

confidence: 94%

“…The declining rate of HBsAg among Egyptian children and general populations was previously reported. [1,2,15] A study conducted in Egypt between 1986 and 1987 found an HBsAg sero-positivity rate of 3.2% among 765 HCWs. [7] More recent data published in 2012 showed a significant decrease of HBsAg (1.5%) among Egyptian HCWs in the Nile delta.…”

Section: Discussionmentioning

confidence: 99%

Hepatitis B virus genotype E infection among Egyptian health care workers

Elmaghloub

Elbahrawy

Didamony

et al. 2017

Journal of Translational Internal Medicine

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“…The study on the woodchuck model demonstrated the occurrence of type-II transmission (Coffin and Michalak, 1999). Other studies showed that the prevalence of HBI oc among pregnant women ranged from 0.0% to 23.5% and among vaccinated children from 0.0% to 64.0% (Figure 1, Supplementary data 1) (Amponsah- Dacosta et al, 2015;Chakvetadze et al, 2011;Chen et al, 2012;Chen and Oon, 2000;Elrashidy et al, 2014;Foaud et al, 2015;Gerlich et al, 2010;Hsu et al, 2015;Khamduang et al, 2013;Liu et al, 2014;Lu et al, 2016;Mu et al, 2009;Ni et al, 2016;Ni et al, 2012;Pande et al, 2013;Rodriguez Lay et al, 2017;S.X. et al, 2017;Salama et al, 2015;Shahmoradi et al, 2012;Su et al, 2017;Su et al, 2013;Utsumi et al, 2010;Xu et al, 2010;Yao et al, 2013;Yokoyama et al, 2017;Zhou et al, 2017).…”

Section: Introductionmentioning

confidence: 87%

Overt and occult hepatitis B infection after neonatal vaccination: mother-to-infant transmission and HBV vaccine effectiveness

Cai

Zhang

et al. 2021

International Journal of Infectious Diseases

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Overt and occult hepatitis B infection (HBI) among mothers and infants were investigated, and the effectiveness of vaccination against HBI was evaluated based on transmission types. Methods: A hospital-based cohort was built with 2,734 mothers and 330 mother-infant pairs. Their demographic data were collected. Serological HBV markers, nested-PCR for HBV genes, viral load detection, and phylogenetic analysis were done. Results: The overall prevalence of HBI among mothers was 12.1% (330/2,734), with 10.4% for the overt type and 1.8% for the occult type. In 330 out of 1,650 (20%) mother-infant pairs, the overall, type-I (from overt mother to overt infant), type-II (from overt mother to occult infant), and type-Ⅲ (from occult mother to occult infant) transmissions were 1.9% (1/54), 5.6% (3/54) and 0.0% (0/7). The refinement of HBI classification improved the estimate of vaccine effectiveness against HBI from 74.4%-80.9% to 94.4%, which was more prominent for type-II. One mother-infant pair with type-II transmission shared nearly identical complete sequences. However, the high rate of lost-to-follow-up could not be ignored. Conclusions: During the transition period, HBV is mainly transmitted from the overt type of HBI mother to infant. Intensive prenatal screening for mothers is vital.

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“…HBV prevalence is decreasing in Egyptian young generations, which may attribute to universal HBV vaccination. It is known in many Egyptian researches that the average prevalence of HBV in Egyptian adults is 8% while the prevalence rate among children was 1.6% (Elrashidy et al, 2014). HBV reactivation does occur in persons who have anti-HBc with and without anti-HBs and no detectable HBsAg in serum (Bisceglie et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Diagnostic strategy for occult hepatitis B virus infection and its clinical implications among patients at Upper Egypt

El-Adly

Meshaal

Mekky

et al. 2020

Journal of Radiation Research and Applied Sciences

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Hepatitis B virus (HBV) infection is an important health problem and the major cause of chronic hepatitis, cirrhosis, and hepatocellular carcinoma (HCC) especially in Upper Egypt. The aim of this study was to estimate the prevalence of HBV among Assiut governorate patients. Our study examined 1085 patients for HBsAg at Assiut governorate, Egypt. Out of the 1085 population tested for HBsAg, 623 (57.5%) were males whereas 462 (42.5%) were females. A total of 165 out 1085 were seropositive for HBsAg (15.2%). The highest seropositive of HBsAg were recorded in 106/623 males (17.1%) compared as 59/462 females (12.8%). HBsAg seropositive were decreased with grassing age, the highest seroprevalence of HBsAg 62/165 (37.6%) was recorded in age ranges between 21 and 30 years, while the lowest seroprevalence of HBsAg 8/165 (4.8%) was recorded in age >60 year. All patients were divided into four groups according to HBV-DNA. Seroprevalence of HBsAg was increased with group 2 (Low titer of HBV-DNA <2000 IU/mL) (46.1%), where highest prevalence of HBsAg was recorded in males (37.6%) compared to as females (8.5%). The lowest seroprevalence of HBsAg were recoded with group 3 (high titer of HBV-DNA > 2000 IU/mL) (14.5%). HBV was common in rural versus urban community areas (78.2% versus 21.8%, respectively). Screening of HBV infection to monitor liver disease progression in HBV carriers by using molecular, biochemical, and serological markers, so that effective treatment can be initiated early before the development of advanced liver disease.

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Absence of occult hepatitis B virus infection in sera of diabetic children and adolescents following hepatitis B vaccination

Cited by 15 publications

References 31 publications

Hepatitis B virus genotype E infection among Egyptian health care workers

Hepatitis B virus genotype E infection among Egyptian health care workers

Overt and occult hepatitis B infection after neonatal vaccination: mother-to-infant transmission and HBV vaccine effectiveness

Diagnostic strategy for occult hepatitis B virus infection and its clinical implications among patients at Upper Egypt

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