Absence of orgasm-induced prolactin secretion in a healthy multi-orgasmic male subject

Haake, Philip; Exton, Michael S.; Haverkamp, Johan; Kramer, Marabeth; Leygraf, Norbert; Hartmann, Uwe; Schedlowski, Manfred; Krueger, Tillmann H.C.

doi:10.1038/sj.ijir.3900823

Cited by 35 publications

(20 citation statements)

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“…This suggests that prolactin elevation might be involved in experiencing sexual satiety. 38,39 Apart from the dopaminergic and prolactin-linked mechanisms, risperidone and quetiapine both have a-adrenergic blocking properties 40 : a 1 -adrenergic mechanisms may be involved in ejaculation disturbance. 6,41 The volume of the ejaculate is reduced or absent while experiencing an orgasm, a condition often referred to retrograde ejaculation or aspermia.…”

Section: Discussionmentioning

confidence: 99%

A Randomized Open-Label Study of the Impact of Quetiapine Versus Risperidone on Sexual Functioning

Knegtering¹,

Castelein²,

Bous³

et al. 2004

Journal of Clinical Psychopharmacology

126

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Section: Discussionmentioning

confidence: 99%

A Randomized Open-Label Study of the Impact of Quetiapine Versus Risperidone on Sexual Functioning

Knegtering¹,

Castelein²,

Bous³

et al. 2004

Journal of Clinical Psychopharmacology

126

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“…1 On the contrary, all types of hyperprolactinemia (HPRL) (idiopathic, tumoral or drug-induced) can inhibit most aspects of male sexual behavior. Therefore, although HPRL is a rather rare condition, it may be a cause of male sexual dysfunction, and should not be neglected since it is reversible, and may result from pituitary tumors likely to result in serious endocrine and visual complications due to the tumor's growth.…”

mentioning

confidence: 99%

Hyperprolactinemia and sexual function in men: a short review

2003

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Erectile dysfunction (ED), generally associated with reduced sexual desire and sometimes with orgasmic or ejaculatory dysfunction, is the major revealing symptom of hyperprolactinemia (HPRL) in men, a condition that should not be neglected since many cases result from pituitary tumors, likely to result in serious complications. It is generally believed that the mechanism of the prolactin (PRL)-induced sexual dysfunctions is a decrease in testosterone secretion. In fact, serum testosterone is normal in many hyperprolactinemic males and there are also testosteroneindependent mechanisms, probably mainly set at the level of the brain's neurotransmittor systems. Systematic determinations of serum PRL found very low prevalences of marked HPRL (435 ng/ml) in ED patients (0.76% in a compilation of over 3200 patients) as well as of pituitary adenomas (0.4%). In addition, the association of HPRL with ED may have been coincidental in some of these cases, since 10% of the HPRLs diagnosed by the usual immunological assays are composed of macroprolactins, which are biologically inactive or little active variants of PRL. Their identification requires a PRL chromatography that is restricted to some specialized laboratories. There is presently no consensus with regards to the screening for HPRL in ED: systematic determination of serum PRL may be justified since HPRL is a serious but reversible disease, while there is presently no reliable clinical, psychometric or hormonal criteria (including serum testosterone level) allowing to restrict its determination to certain categories of the ED patients without risk of neglecting some HPRLs. In case of consistent HPRL, searching for a hypothalamic or pituitary tumor is mandatory. Dopamine-agonist therapy is the first choice treatment for the PRL-induced sexual dysfunctions. Additional sexual counselling may be necessary for certain patients. Keywords: hyperprolactinemia; erectile dysfunction; inhibited sexual desire; anorgasmia; retarded ejaculation; review Prolactin (PRL) has no known role in physiological control of human sexual behavior, except a possible contribution of the orgasm-induced PRL secretion to the sexual-satiation mechanisms, since sexual satiation has not been observed in a multiorgasmic male. 1 On the contrary, all types of hyperprolactinemia (HPRL) (idiopathic, tumoral or drug-induced) can inhibit most aspects of male sexual behavior. Therefore, although HPRL is a rather rare condition, it may be a cause of male sexual dysfunction, and should not be neglected since it is reversible, and may result from pituitary tumors likely to result in serious endocrine and visual complications due to the tumor's growth. Sexual problems of hyperprolactinemic menA literature review encompassing more than 300 hyperprolactinemic men 2 found sexual dysfunctions in 88%, including erectile dysfunction (ED) almost each time. The most typical pattern associated ED with a reduced sexual desire. Delayed or absent orgasm was associated in some cases, but virtually never isolated. Some cases ...

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“…L'augmentation de sa s6cr6tion qu'induit physiologiquement I'orgasme dans les deux sexes pourrait cependant contribuer au m~canisme de la satiet6 sexuelle puisqu'elle n'a pas et6 observee chez un homme multi-orgasmique [20]. risme, qui peut ~tre fatal a I'occasion d'une d~compensa-tion), visuelles (hemianopsie bitemporale et au maximum cecite en cas de poussee evolutive) ou tumorales, dues la croissance de la tumeur.…”

Section: Introductionunclassified

Hyperprolactinémie et fonction sexuelle chez l’homme

Buvat

Bou-Jaoude

2005

Androl.

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Absence of orgasm-induced prolactin secretion in a healthy multi-orgasmic male subject

Cited by 35 publications

References 10 publications

A Randomized Open-Label Study of the Impact of Quetiapine Versus Risperidone on Sexual Functioning

A Randomized Open-Label Study of the Impact of Quetiapine Versus Risperidone on Sexual Functioning

Hyperprolactinemia and sexual function in men: a short review

Hyperprolactinémie et fonction sexuelle chez l’homme

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