Absence of ‘over‐the‐counter’ medicinal products in on‐line prescription records: a risk factor of overlooking interactions in the elderly

Olesen, Charlotte; Harbig, Philipp; Barat, Ishay; Damsgaard, Else Marie

doi:10.1002/pds.3362

Cited by 33 publications

(26 citation statements)

References 23 publications

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“…Thus, more refined future approaches could also focus on temporarily varying COV approximations (e.g., similar to the extension of the proportion of days covered) or on more specific ways than the ’15‐day rule’ to address poor adherence while considering individual drugs and their specific administration regimens. Finally, unmeasured and possibly time‐dependent confounding cannot be ruled out with respect to factors influencing outcome, exposure, or being equally related to both (e.g., indication, contraindication, disease severity, or over‐the‐counter drugs) …”

Section: Discussionmentioning

confidence: 99%

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Comparative evaluation of methods approximating drug prescription durations in claims data: modeling, simulation, and application to real data

Meid

Heider

Adler

et al. 2016

Pharmacoepidemiology and Drug

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Based on theoretically most accurate approximations and practically reasonable estimates, the individual COV approach was preferable over the population-averaged defined daily dose technique, although the latter might be justified in certain situations. Advantages of the COV approach are expected to be even bigger for drug therapies with particularly large dosing heterogeneity. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Discussionmentioning

confidence: 99%

“…Finally, unmeasured and possibly timedependent confounding cannot be ruled out with respect to factors influencing outcome, exposure, or being equally related to both (e.g., indication, contraindication, disease severity, or over-the-counter drugs). [46][47][48][49]…”

Section: Discussionmentioning

confidence: 99%

Comparative evaluation of methods approximating drug prescription durations in claims data: modeling, simulation, and application to real data

Meid

Heider

Adler

et al. 2016

Pharmacoepidemiology and Drug

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“…[3] Our findings are similar to outpatient elderly populations, for example a Danish study found that 74% of elderly patients were using over the counter medicines that were not listed in the medical record. [32] Cohen et al found that in a sample of 212 geriatric patients, 64% took supplements, but their use was documented in only 35% of medical charts. [9]…”

Section: Discussionmentioning

confidence: 99%

Medical reconciliation of dietary supplements: Don’t ask, don’t tell

Gardiner

Sadikova

Filippelli

et al. 2015

Patient Education and Counseling

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Objective To explore inpatient reconciliation of dietary supplement (DS) use and determine characteristics associated with DS documentation. Methods We analyzed DS use among 558 inpatients recruited from the Re-Engineered Discharge clinical trial to identify: 1) if patients self-reported DS and 2) if DS use was documented at admission. We examined socio-demographics for association with documentation using chi squares and t-tests. Logistic regression was performed to assess adjusted associations with DS documentation. Results Sixty percent reported DS use (n=333). Among users, 36% had admission DS documentation, 20% were asked about use at admission, 18% reported disclosing use to a provider, and 48% reported they would continue to use DS. Overall, 6% of participants were asked, disclosed, and had documentation of DS. Logistic regression revealed increased age associated with lower odds of DS documentation. Identifying as Hispanic or African American reduces DS documentation odds compared to those identifying as white. Conclusions There is lack of consistent DS medical reconciliation in the inpatient setting. While more than half of patients used DS prior to hospitalization, most were not asked about use on admission. Practice Implications This study adds to literature on medical reconciliation which requires that providers inquire and document patient DS use.

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“…As a result, drug-drug interactions between OTC and prescription medicines (Rx) may occur. While patients are aware of possible drug-drug interactions between Rx medicines, patient knowledge regarding interactions between OTC and Rx medicines has not been well studied, although the occurrence of the aforementioned interactions has been described as frequent (Olesen et al 2013 ; Sihvo et al 2000 ).…”

Section: Introductionmentioning

confidence: 99%

“…Olesen et al found that in Denmark, 50% of elderly patients taking OTC medicines were exposed to potential interactions (Olesen et al 2013 ); and Sihvo et al described that four percent of OTC users had taken drug combinations with the potential for clinically significant interactions (xSihvo et al 2000 ). Based on this knowledge, it is necessary to study the frequency of and possible risks with the concomitant use of OTC and Rx medicines in more detail.…”

Section: Introductionmentioning

confidence: 99%

Safety concerns in simultaneous use of prescription and 'over-the-counter’ medicines- results of patient survey in Estonia

Gavronski

Volmer

2014

SpringerPlus

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During the last decades, the share of population using prescription (Rx) medicines has considerably increased. With the wider introduction of self-medication and the use of over-the-counter (OTC) medicines, there is a real threat for drug-drug interactions between Rx and OTC medicines neither identified nor overseen by healthcare specialists.The objectives of this survey were to ascertain how often, and for what conditions OTC and Rx medicines are used simultaneously, and to discuss possible health hazards connected with the concomitant use of these medicines.This survey was designed as a descriptive, cross-sectional questionnaire-based interview which was conducted amongst pharmacy customers and patients in urban and rural areas of Estonia in between 2010–2012.In total, 712 respondents participated in the survey. Of those, 50.4% reported concomitant use of Rx and OTC medicines during the survey. The simultaneous use of Rx and OTC medicines increased with age and the number of chronic diseases (both p < 0.001). Of chronic patients, 37.1% used Rx and OTC medicines on a daily basis over a four-week period before the survey, and considering reported chronic diseases and the most widespread OTC medicines, they could encounter drug-drug interactions between Rx medicines (e.g. antihypertensives, anti-inflammatory medicines) and OTC medicines (e.g. paracetamol, NSAID-s, herbal medicines and adsorbents).The present survey revealed frequent concomitant use of Rx and OTC medicines. Especially vulnerable are chronic and elderly patients. In the future, both patients and healthcare specialists should pay more attention to possible drug-drug interactions of Rx and OTC medicines.

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Absence of ‘over‐the‐counter’ medicinal products in on‐line prescription records: a risk factor of overlooking interactions in the elderly

Cited by 33 publications

References 23 publications

Comparative evaluation of methods approximating drug prescription durations in claims data: modeling, simulation, and application to real data

Comparative evaluation of methods approximating drug prescription durations in claims data: modeling, simulation, and application to real data

Medical reconciliation of dietary supplements: Don’t ask, don’t tell

Safety concerns in simultaneous use of prescription and 'over-the-counter’ medicines- results of patient survey in Estonia

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