Absence of phospholipase A2 activity in genital Mycoplasma hominis

Walther, Thomas; Stepan, Holger; Baumann, Lutz; Walther, Diego J.; Faber, R.

doi:10.1515/jpme.1998.26.3.208

Cited by 2 publications

(2 citation statements)

References 7 publications

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“…However, after adjustments for age, education and smoking, only the age !20 was identified as an independent risk factor of M. hominis infection during pregnancy. Although the causative role of M. hominis infection in prematurity was excluded in some of the studies [28,29], another found this relation very likely [30]. According to Hillier et al [17] among women with BV, the highest risk of preterm delivery of a low birth weight infant (!2,500 g) was found among those with both vaginal bacteroides and M. hominis (OR = 2.1).…”

Section: Discussionmentioning

confidence: 99%

Do Microbiological Factors Account for Poor Pregnancy Outcome among Unmarried Pregnant Women in Poland?

Kalinka

Laudański²,

Hanke³

et al. 2003

Fetal Diagn Ther

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Objective: Being unmarried is a well-known risk factor for poor pregnancy outcome such as preterm delivery and intrauterine growth restriction. The aim of this prospective study was to assess the prevalence and risk of bacterial vaginosis (BV) and selected bacteria isolated from the lower genital tract and to determine the socioeconomic and microbiological characteristics that might be responsible for poor pregnancy outcome observed among unmarried pregnant women. Methods: The study population comprised 196 pregnant women attending 10 randomly selected outpatient maternity units in the Lodz region, central Poland. Cervicovaginal samples were obtained between 8 and 16 weeks of gestation. Based on Spiegel’s criteria, gram-stained vaginal smears were examined for BV and the BV-associated flora was sought by culture. To evaluate the risk factors, relative risk ratios were calculated using EPI INFO software. Results: Among 196 pregnant women, 40 (20.4%) were unmarried. BV was diagnosed among 55 (28.1%) women studied.In the univariate analysis, unmarried pregnant women were characterized by younger age, primary educational level, poor economic situation and excessive smoking during pregnancy, as compared to married women. The unmarried status was a borderline risk factor for BV (OR = 1.83, 95% CI 0.94–4.9) after adjustment for age, smoking and education. An analysis of the microbiological culture from the lower genital tract revealed that unmarried pregnant women had a higher risk for several types of pathological microflora, as compared to married women. However, this finding was significant only for Mycoplasma hominis. The independent risk factors of M. hominis were the young age of the subject and a low concentration of Lactobacillus spp. Conclusions: The observed socioeconomic, demographic and microbiological differences between unmarried and married women could be responsible for the poor pregnancy outcome among unmarried pregnant women in Poland. Unmarried pregnant women should be covered by comprehensive medical care even before pregnancy.Further studies taking into account the role of psychological stress, patterns of sexual behavior and substance abuse during pregnancy could help identify the factors responsible for adverse pregnancy outcome among unmarried pregnant women.

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Section: Discussionmentioning

confidence: 99%

Do Microbiological Factors Account for Poor Pregnancy Outcome among Unmarried Pregnant Women in Poland?

Kalinka

Laudański²,

Hanke³

et al. 2003

Fetal Diagn Ther

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“…However, Glass and colleagues (96) were unable to identify phospholipase activity in the serotype 3 ureaplasma strain for which the complete genome was sequenced and gave the same possible explanations as those for the apparent lack of IgA1 protease activity. Interestingly, Walther et al (328) were unable to demonstrate phospholipase activity in M. hominis and they were also unable to detect phospholipase A2 coding sequences in DNA analysis (271). These findings suggest M. hominis is not important in the initiation of premature labor through elaboration of phospholipases and stimulation of prostaglandin activity.…”

Section: Secretory Productsmentioning

confidence: 97%

Mycoplasmas and Ureaplasmas as Neonatal Pathogens

Katz²,

2005

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SUMMARY The genital mycoplasmas represent a complex and unique group of microorganisms that have been associated with a wide array of infectious diseases in adults and infants. The lack of conclusive knowledge regarding the pathogenic potential of Mycoplasma and Ureaplasma spp. in many conditions is due to a general unfamiliarity of physicians and microbiology laboratories with their fastidious growth requirements, leading to difficulty in their detection; their high prevalence in healthy persons; the poor design of research studies attempting to base association with disease on the mere presence of the organisms in the lower urogenital tract; the failure to consider multifactorial aspects of diseases; and considering these genital mycoplasmas only as a last resort. The situation is now changing because of a greater appreciation of the genital mycoplasmas as perinatal pathogens and improvements in laboratory detection, particularly with regard to the development of powerful molecular nucleic acid amplification tests. This review summarizes the epidemiology of genital mycoplasmas as causes of neonatal infections and premature birth; evidence linking ureaplasmas with bronchopulmonary dysplasia; recent changes in the taxonomy of the genus Ureaplasma; the neonatal host response to mycoplasma and ureaplasma infections; advances in laboratory detection, including molecular methods; and therapeutic considerations for treatment of systemic diseases.

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Absence of phospholipase A2 activity in genital Mycoplasma hominis

Cited by 2 publications

References 7 publications

Do Microbiological Factors Account for Poor Pregnancy Outcome among Unmarried Pregnant Women in Poland?

Do Microbiological Factors Account for Poor Pregnancy Outcome among Unmarried Pregnant Women in Poland?

Mycoplasmas and Ureaplasmas as Neonatal Pathogens

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