Absence of porcine parvovirus transmission to man

Wattanavijarn, Wattana; Tesprateep, Ted; Burke, Donald S.

doi:10.1016/0035-9203(85)90097-5

Cited by 7 publications

(3 citation statements)

References 2 publications

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“…Porcine parvovirus (PPV) is a member of the family Parvoviridae (Mayr et al, 1968). PPV is widespread in swine herds, despite vaccination (Siegl, 1976;Gillick, 1977;Wattanavijarn et al, 1985). The virulent strains cause reproductive failures in swine, represented by stillbirth, mummification, embryonic death, infertility (SMEDIsyndrome) and delayed return to oestrus (Redman et al, 1974;Mengeling & Cutlip, 1975;Joo et al, 1976a, b, c;Cutler et al, 1983).…”

Section: Introductionmentioning

confidence: 99%

Study of the virulence and cross-neutralization capability of recent porcine parvovirus field isolates and vaccine viruses in experimentally infected pregnant gilts

Zeeuw

Leinecker

Herwig³

et al. 2007

Journal of General Virology

103

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The pathogenicity of two recent German field isolates of Porcine parvovirus (PPV-27a and PPV-143a) and two vaccine viruses [PPV-NADL-2 and PPV-IDT (MSV)], which are used for the production of inactivated vaccines, was investigated by inoculation of pregnant sows at day 40 of gestation. Post-infection sera of these sows as well as antisera prepared in rabbits by immunization with the four above-mentioned PPV isolates and with the virulent strain PPV-Challenge (Engl.) were tested for their homologous and heterologous neutralization activities. All antisera had high neutralization activity against the vaccine viruses, the PPV-Challenge (Engl.) virus and PPV-143a, but much lower activity against PPV-27a. These results suggest that PPV-27a represents a new antigenic variant or type of PPV and vaccines based on the established vaccine viruses may not be fully protective against this field isolate. PPV-27a has been characterized based on the amino acid sequences of the capsid protein as a member of a new and distinct PPV cluster (Zimmermann et al., 2006). Interestingly, the homologous neutralizing antibody titres of the sera of all three pigs and both rabbits inoculated or immunized with PPV-27a were 100-to 1000-fold lower than the heterologous titres against any of the other viruses. The low homologous neutralizing antibody titres suggest a possible, yet undefined, immune escape mechanism of this PPV isolate.

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Section: Introductionmentioning

confidence: 99%

Study of the virulence and cross-neutralization capability of recent porcine parvovirus field isolates and vaccine viruses in experimentally infected pregnant gilts

Zeeuw

Leinecker

Herwig³

et al. 2007

Journal of General Virology

103

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“…PPV is not known to infect humans, and several serologic studies suggest that respiratory or skin contact exposure with PPV‐infected animals does not lead to infection. For example, in a study of 56 workers who had close daily contact for at least a year with PPV‐infected pigs, none developed detectable PPV antibodies 8 . The exposures in this setting were most likely to be through the oral or respiratory route.…”

Section: Discussionmentioning

confidence: 98%

Investigation of porcine parvovirus among persons with hemophilia receiving Hyate:C porcine factor VIII concentrate

et al. 2000

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“…There is no evidence that porcine parvovirus may be transmitted to humans through physical contact. Although most pigs naturally acquire antibodies to PPV, a previous study reported that none of 56 workers on a pig farm had antibodies directed against porcine parvovirus [6], which suggests that PPV does not cross the species barrier.…”

Section: Discussionmentioning

confidence: 99%

Viral pharmacovigilance study of haemophiliacs receiving porcine factor VIII

et al. 2002

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Porcine factor VIII (FVIII; Hyate:C; Speywood Biopharm Ltd, UK) has been used since 1980 for the treatment both of patients with acquired haemophilia and those with congenital haemophilia and inhibitory antibodies. Each batch is extensively screened using cell-culture techniques to confirm the absence of viruses. The production process does not incorporate specific virucidal treatment steps, such as heat treatment or the addition of a solvent/detergent mixture. Low levels of porcine parvovirus were detected in some batches of the product in late 1996 and supply was suspended. In this retrospective study, sera from 81 recipients of porcine FVIII and 125 other volunteers were screened for evidence of antibodies against a range of porcine viruses: porcine parvovirus (PPV), encephalomyocarditis virus (EMCV), and porcine respiratory and reproductive syndrome virus (PRRSV). The 125 volunteer controls included subjects from six categories: healthy control subjects, pig abattoir personnel, personnel involved in the manufacture of porcine FVIII, recipients of porcine heparin, recipients of porcine insulin, and haemophiliacs treated only with human FVIII. No antibodies to PPV or PRRSV were detected in any subject. Four patients and two volunteers were found to have antibodies to EMCV, but this incidence is similar to that observed in the general population. In conclusion, there was no evidence of transmission of PPR or other marker porcine virus associated with the use of porcine FVIII concentrate (Hyate: C).

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Absence of porcine parvovirus transmission to man

Cited by 7 publications

References 2 publications

Study of the virulence and cross-neutralization capability of recent porcine parvovirus field isolates and vaccine viruses in experimentally infected pregnant gilts

Study of the virulence and cross-neutralization capability of recent porcine parvovirus field isolates and vaccine viruses in experimentally infected pregnant gilts

Investigation of porcine parvovirus among persons with hemophilia receiving Hyate:C porcine factor VIII concentrate

Viral pharmacovigilance study of haemophiliacs receiving porcine factor VIII

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