Absence of Povidone-Iodine-Induced Mutagenicity in Mice and Hamsters

Merkle, J.; Zeller, H.

doi:10.1002/jps.2600680133

Cited by 8 publications

(3 citation statements)

References 6 publications

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“…The present results are in agreement with our recent data concerning the evaluation of DNA damaging activity of the compound in human lymphocytes and 2 human tumor cell lines, HeLa and Caco-2 (7). Since the tested compound, FS-1 is iodophor, it would be of interest to stress that widely used representative of this class of preparations, povidone-iodine, was found non-genotoxic in some in vitro mutagenicity tests in bacteria and mammalian cells as well in mouse bone marrow MN assay (20)(21)(22). These findings support the results obtained in this study.…”

Section: Discussionsupporting

confidence: 87%

Investigations of genotoxic activity of the antimicrobial/antiviral agent FS-1 in rodents by means of the micronucleus and the comet assays

Nersesyan¹,

Il’in²,

Kulmanov³

et al. 2011

Arch Oncol

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Background: FS-1 is a complex of iodine and synthesized polysaccharides and it is very effective against a number of microbe and virus strains. The aim of the study was to evaluate possible genotoxic properties of FS-1. Methods: The compound was studied in rat and mouse bone marrow micronucleus (MN) assay and the comet assay in murine peripheral blood leukocytes, hepatocytes, and kidney cells. Two treatment protocols were applied, namely acute and subacute ones. In the first protocol, the compound was administered orally once and in subacute treatment two times, 24 h apart. The animals were sacrificed 24 h after the last treatment, and appropriate cells were used to assess DNA damage and MN induction. Results: In none of the tests (MN and comet assays) significant increase compared with respective negative controls was observed. Conclusion: The fact that the compound neither induces DNA damage in various organs of mice nor is effective in the induction of MN in bone marrow cells of rats and mice is important for future genotoxicity studies of FS-1, which can be used in clinical medicine after additional testing of safety for humans

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Section: Discussionsupporting

confidence: 87%

Investigations of genotoxic activity of the antimicrobial/antiviral agent FS-1 in rodents by means of the micronucleus and the comet assays

Nersesyan¹,

Il’in²,

Kulmanov³

et al. 2011

Arch Oncol

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show abstract

“…On the other hand, single or repeated intraperitoneal administration of PVP-I (up to a maximum concentration of 82.2 mg/kg b.w.) to mice or Chinese hamsters did not show any chromosome-damaging activity of the test agent in vivo as revealed by the dominant lethal assay, the micronucleus and bone marrow tests [27]. Moreover, testing PVP-I and its constituents, polyvinylpyrrolidone and iodine, in the mouse lymphoma L5178Y assay, which detects 'chromosomal mutations', and in the Balb/c 3T3 cell transformation assay also gave negative results [28].…”

Section: Discussionmentioning

confidence: 99%

Virucidal and Chlamydicidal Activities of Eye Drops with Povidone-Iodine Liposome Complex

et al. 2000

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Povidone-iodine (PVP-I) is a broad-spectrum microbicide with in vitro activity against bacteria, viruses, fungi and protozoans. A 5% solution of PVP-I proved to be highly effective in ophthalmic surgery for the prophylaxis of endophthalmitis. For the antiseptic treatment of eye infections a novel application form of PVP-I has been developed by using a PVP-I liposome complex which demonstrated an excellent antimicrobial efficacy. In this study it could be shown that the novel liposomal formulations containing 2.5 or 5% PVP-I were as active as the aqueous solution against herpes simplex virus type 1, adenovirus type 8, coxsackievirus A9 and Chlamydia trachomatis in cell culture referring to equal PVP-I concentrations. Long-term cytotoxicity experiments demonstrated a moderate cytotoxicity for both formulations with a better tolerability of the liposomal PVP-I formulation compared with the aqueous solution. There is no evidence for a genotoxic activity of these agents.

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“…Since the tested compound is iodophore, it would be of interest to stress that widely used rep resentative of this kind of preparations, povidone iodine, was found non genotoxic in some in vitro mutagenicity tests in bacteria and mammalian cells as well in mouse bone marrow MN assay [13][14][15].…”

mentioning

confidence: 99%

Investigations of genotoxic activity of antimicrobial/antiviral agent FS-1 in human lymphocytes and tumor cell

2011

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Absence of Povidone-Iodine-Induced Mutagenicity in Mice and Hamsters

Cited by 8 publications

References 6 publications

Investigations of genotoxic activity of the antimicrobial/antiviral agent FS-1 in rodents by means of the micronucleus and the comet assays

Investigations of genotoxic activity of the antimicrobial/antiviral agent FS-1 in rodents by means of the micronucleus and the comet assays

Virucidal and Chlamydicidal Activities of Eye Drops with Povidone-Iodine Liposome Complex

Investigations of genotoxic activity of antimicrobial/antiviral agent FS-1 in human lymphocytes and tumor cell

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