Absence of relationship between <i>Schistosoma japonicum</i> and
 
hepatitis B virus infection in the Dongting lake region, China

Ye, X.-P.; Fu, Yifei; Anderson, Roy M.; Nokes, D. James

doi:10.1017/s0950268898008917

Cited by 8 publications

(3 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This observation could be explained by an increased susceptibility to HBV caused by schistosome infections. On the other hand, there are reports of no relationship between schistosomiasis and HBV [ 86 , 87 ]. In addition, experiments with animals do not support increased susceptibility to HBV in schistosomiasis.…”

Section: Effects Of Schistosomes On Immunological Disorders or Infmentioning

confidence: 99%

Schistosome: Its Benefit and Harm in Patients Suffering from Concomitant Diseases

Osada

Kanazawa

2011

BioMed Research International

View full text Add to dashboard Cite

Schistosomiasis is an important tropical disease affecting approximately 200 million people worldwide. Because of its chronicity and robust immunomodulatory activity, the effects of schistosomes on other diseases, such as allergies, autoimmunity, and infectious diseases, have been studied extensively in both epidemiological and experimental settings. In this paper, we summarize the beneficial and harmful effects of schistosomes. The importance of controlling schistosomiasis is also discussed.

show abstract

Section: Effects Of Schistosomes On Immunological Disorders or Infmentioning

confidence: 99%

Schistosome: Its Benefit and Harm in Patients Suffering from Concomitant Diseases

Osada

Kanazawa

2011

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…Very few (and contradictory) studies describing possible interactions between HBV and S. mansoni are available. Although some studies have shown little or no epidemiological association between S. mansoni infection and the presence of antibody to hepatitis B virus core antigen (anti-HBc) and hepatitis B surface antigen (HBsAg) (16)(17)(18)(19), others have shown that concurrence of these two infections correlates with a more severe liver disease and a longer persistence of HBsAg (20,21). Based on the results of this report, it is possible that Th1-type cytokines may inhibit HBV replication during human S. mansoni infection, irrespective of the presence of Th2-type cytokines in the liver.…”

Section: Inhibition Of Hbv Replication During S Mansoni Infectionmentioning

confidence: 99%

Inhibition of Hepatitis B Virus Replication during Schistosoma mansoni Infection in Transgenic Mice

McClary

Koch

Chisari

et al. 2000

The Journal of Experimental Medicine

View full text Add to dashboard Cite

Although coinfection of hepatitis B virus (HBV) and Schistosoma mansoni is a frequent event in humans, little is known about the interactions between these two pathogens. S. mansoni infection induces T helper cell type 2 (Th2)–type cytokines in the liver of humans and mice. The intrahepatic induction of nitric oxide (NO) and Th1-type cytokines, such as interferon (IFN)-γ and IFN-α/β, inhibits HBV replication noncytopathically in the liver of transgenic mice. To examine whether S. mansoni infection and the accompanying induction of Th2-type cytokines could interfere with HBV replication in the liver, HBV transgenic mice were infected with S. mansoni. By 5 wk after infection, HBV replication disappeared concomitant with the intrahepatic induction of NO and Th1-type cytokines, and in the absence of Th2-type cytokines. By 6–8 wk after infection, HBV replication remained undetectable and this was associated with further induction of NO and Th1-type cytokines together with the appearance of Th2-type cytokines. The S. mansoni–dependent antiviral effect was partially blocked by genetically deleting IFN-γ, although it was unaffected by deletion of IFN-α/β. These results indicate that IFN-γ (probably via NO) mediates most of this antiviral activity and that Th2-type cytokines do not counteract the antiviral effect of IFN-γ. Similar events may suppress HBV replication during human S. mansoni infection.

show abstract

“…However, this could be explained by the frequent need of schistosomiasis patients for blood transfusion, especially on considering the poor infection control measures in countries where this disease is endemic. In contrast, other studies rejected the thesis stating any relationship between schistosomiasis and HBV [ 48 , 49 ]. Woodchucks are susceptible to infection with both schistosoma and woodchuck hepatitis virus (WHV) [ 50 ].…”

Section: Introductionmentioning

confidence: 99%

Schistosomiasis, hepatitis B and hepatitis C co-infection

Gasim

Bella

Adam

2015

Virol J

View full text Add to dashboard Cite

BackgroundSchistosomiasis is a significant health problem in more than 70 countries distributed between Africa, Asia and South America, with an infection rate of one in 30 individuals. Data on Schistosomiasis, Hepatitis B virus (HBV) and Hepatitis C virus (HCV) co-infection are scarce; however, there is a high prevalence in countries where schistosomiasis is endemic.MethodsA systematic search was performed on published data from 1980–2014. Published papers in the databases Google, Medline, PubMed, and MiPc library were searched using the keywords epidemiology, pathogenesis and outcomes of HBV, HCV and schistosomiasis and data were extracted from the relevant studies.ResultsThe prevalence of HBV/schistosomiasis co-infection in countries where schistosomiasis is endemic was high, ranging between 9.6 to approximately 64% in Egypt, and a maximum of 15.8% among hospitalized patients in Brazil. Concurrent infection between HBV and schistosomiasis is often associated with countries where schistosomiasis is endemic and may lead to chronic liver inflammation. Similarly, HCV infection rates in schistosomiasis populations range from 1% in Ethiopia reaching up to 50% in Egypt.ConclusionThere is controversy regarding the effects of HBV and HCV on schistosomiasis and vice versa. Vaccination might be a solution to the era of schistosomiasis and co-infection with HBV and HCV.

show abstract

Absence of relationship between Schistosoma japonicum and hepatitis B virus infection in the Dongting lake region, China

Cited by 8 publications

References 9 publications

Schistosome: Its Benefit and Harm in Patients Suffering from Concomitant Diseases

Schistosome: Its Benefit and Harm in Patients Suffering from Concomitant Diseases

Inhibition of Hepatitis B Virus Replication during Schistosoma mansoni Infection in Transgenic Mice

Schistosomiasis, hepatitis B and hepatitis C co-infection

Contact Info

Product

Resources

About