Absence of Rheumatoid Arthritis in Schizophrenia*

Mellsop, Graham; Koadlow, L.; Syme, JR; Whittingham, Senga

doi:10.1111/j.1445-5994.1974.tb03183.x

Cited by 57 publications

(29 citation statements)

References 36 publications

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“…Numerous studies including several tens of thousands of patients were identified (7,18,85,(198)(199)(200)(201)(202)(203)(204)(205)(206)(207)(208)(209)(210)(211), the vast majority of which found a decreased frequency of rheumatoid arthritis among people with schizophrenia. Explanations may be of a genetic, environmental (institutionalization and sedentary lifestyle due to negative symptoms), pharmacological (analgesic and anti-inflammatory effects of antipsychotic drugs) and biochemical (histo-imcompatibility factors) nature [for review see (212,213)].…”

Section: Skin and Connective Tissue Diseases (392 Medline Hits)mentioning

confidence: 99%

Physical illness and schizophrenia: a review of the literature

Leucht

Burkard

Henderson³

et al. 2007

Acta Psychiatr Scand

564

358

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Sartorius N. Physical illness and schizophrenia: a review of the literature.Objective: The lifespan of people with schizophrenia is shortened compared to the general population. We reviewed the literature on comorbid physical diseases in schizophrenia to provide a basis for initiatives to fight this unacceptable situation. Method: We searched MEDLINE (1966( -May 2006 combining the MeSH term of schizophrenia with the 23 MeSH terms of general physical disease categories to identify relevant epidemiological studies. Results: A total of 44 202 abstracts were screened. People with schizophrenia have higher prevalences of HIV infection and hepatitis, osteoporosis, altered pain sensitivity, sexual dysfunction, obstetric complications, cardiovascular diseases, overweight, diabetes, dental problems, and polydipsia than the general population. Rheumatoid arthritis and cancer may occur less frequently than in the general population. Eighty-six per cent of the studies came from industrialized countries limiting the generalizability of the findings. Conclusion: The increased frequency of physical diseases in schizophrenia might be on account of factors related to schizophrenia and its treatment, but undoubtedly also results from the unsatisfactory organization of health services, from the attitudes of medical doctors, and the social stigma ascribed to the schizophrenic patients. Summations• According to this review it has been known for decades that incidences physical diseases are frequent in schizophrenia. Nevertheless, some areas such as infectious diseases have not been sufficiently studied.• Psychiatrists are often not trained well enough in the detection and treatment of physical diseases.They must be aware of the frequent medical comorbidities and should play a more active role in their diagnosis, prevention, and treatment.• Other necessary strategies include the education of patients, general practitioners and of doctors working in other medical specialities. The access to medical care of the mentally ill also needs to be improved, among others, by reducing the stigma associated with mental disorders. Considerations• The review covered a broad area of research accordingly, focusing attention to details has not been possible.• Despite the broad search strategy, studies not covered by MEDLINE or not indexed by the MeSH term of schizophrenia could have been missed. • Due to considerable differences in the design and quality of the studies in assorted and diverse areas, quantitative approaches using meta-analysis were not possible, but should be the target of future reviews focusing.

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Section: Skin and Connective Tissue Diseases (392 Medline Hits)mentioning

confidence: 99%

Physical illness and schizophrenia: a review of the literature

Leucht

Burkard

Henderson³

et al. 2007

Acta Psychiatr Scand

564

358

View full text Add to dashboard Cite

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“…Disturbances in carbohydrate metabolism and abnormalities of plasma and urinary glycoproteins have been reported in schizophrenia [6][7][8] and a very low incidence of carcinoma and rheumatoid arthritis has also been observed [9,10]. In this report, ·1,3FT activities were assayed in 44 patients with schizophrenia and in 50 healthy controls; 4 patients were found to be deficient in plasma ·1,3FT for the first time in Japan.…”

Section: Introductionmentioning

confidence: 99%

Plasma α1,3-Fucosyltransferase Deficiency in Schizophrenia

Yazawa

Tanaka

Nishimura

et al. 1999

Exp Clin Immunogenet

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Levels of plasma α1,3-fucosyltransferase (α1,3FT) were assayed in 44 patients with schizophrenia and in 50 healthy controls. Significantly reduced enzyme activities were observed in patients (p < 0.05) and 4 unrelated patients were found, for the first time in Japan, to be deficient in the enzyme activity. Two point mutations in the coding region of the FUT6 gene encoding plasma α1,3FT that were responsible for the inactivation of the enzyme activity were detected in those patients. Genotyping of the Le gene (FUT3) in these patients demonstrated that 2 of them were also FUT3 deficient and were grouped as Lewis– individuals whereas the rest were Lewis+.

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“…Acute exacerbations alternating with the psychosis have been reported. Mellsop et al (1974) cited 6 reports between 1939 and 1963 of the rarity of coincidence of the 2 conditions in the same individual. In their own study of 301 middle-aged schizophrenic women they found neither clinical nor radiological evidence of rheumatoid arthritis.…”

Section: Parkinson's Diseasementioning

confidence: 99%