Absence of TLR2 influences survival of neutrophils after infection with Candida albicans

Tessarolli, Vanessa; Gasparoto, Thaís Helena; Lima, Hayana Ramos; Figueira, Eduardo Aleixo; Garlet, Thiago; Torres, Sérgio Aparecido; Garlet, Gustavo; Silva, Joao Santana Da; Campanelli, Ana Paula

doi:10.1080/13693780902964339

Cited by 24 publications

(28 citation statements)

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“…Langerhans cells or T lymphocytes that are important in the host response to Candida infections [39,40]. However, as with the RHOE models [25], the introduction of these immune cells into the mucosal models is possible and the likelihood of generating more complex tissue engineered oral mucosal models containing several cell types is imminent.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of tissue engineered models of the oral mucosa to investigate oral candidiasis

Yadev

Murdoch

Saville

et al. 2011

Microbial Pathogenesis

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Candida albicans is a commensal organism that can be isolated from the majority of healthy individuals. However, in certain susceptible individuals C.albicans can become pathogenic leading to the mucocutaneous infection; oral candidiasis. Murine models and in vitro monolayer cultures have generated some data on the likely virulence and host factors that contribute to oral candidiasis but these models have limitations. Recently, tissue engineered oral mucosal models have been developed to mimic the normal oral mucosa but little information is available on their true representation. In this study we assessed the histological features of three different tissue engineered oral mucosal models compared to the normal oral mucosa and analysed both cell damage and cytokine release following infection with C.albicans. Models comprised of normal oral keratinocytes and a fibroblast-containing matrix displayed more similar immunohistological and proliferation characteristics to normal mucosa compared to models composed of an oral carcinoma cell line. Although all models were invaded and damaged by C.albicabs in a similar manner, the cytokine response was much more pronounced in models containing normal keratinocytes. These data suggest that models based on normal keratinocytes atop a fibroblast-containing connective tissue will significantly aid in dissecting the molecular pathogenesis of oral candidiasis.

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Section: Discussionmentioning

confidence: 99%

Evaluation of tissue engineered models of the oral mucosa to investigate oral candidiasis

Yadev

Murdoch

Saville

et al. 2011

Microbial Pathogenesis

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“…179 Accordingly, in an intraperitoneal model of candidiasis, fungal clearance is delayed in mice lacking TLR2. 180 However, a few other studies showed controversial results. Upon intravenous C. albicans infection, mice lacking TLR2 have an improved fungal clearance and better survival compared to wild-type mice.…”

Section: The Roles Of Prrs: Findings Using Prr-deficient Micementioning

confidence: 99%

The role of pattern recognition receptors in the innate recognition ofCandida albicans

Zheng

Wang

et al. 2015

Virulence

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“…In mice, TLR2 expression is required for optimal neutrophil chemotaxis, pro-inflammatory cytokine production and MPO activity in response to murine C. albicans infection. 105 However, TLR signaling is not essential for anti-Candida activity of human PMN as shown by testing PMN from patients with IRAK4 deficiency, a central component in TLR signaling. 106 Finally, neutrophils constitutively express FcgR; specifically, FcgRIII (CD16) activation can initiate characteristic neutrophil activation mechanisms, e.g., degranulation and respiratory burst.…”

Section: The Various Roles Of Neutrophils In C Albicans Sepsismentioning

confidence: 99%

Host response toCandida albicansbloodstream infection and sepsis

et al. 2015

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Absence of TLR2 influences survival of neutrophils after infection with Candida albicans

Cited by 24 publications

References 0 publications

Evaluation of tissue engineered models of the oral mucosa to investigate oral candidiasis

Evaluation of tissue engineered models of the oral mucosa to investigate oral candidiasis

The role of pattern recognition receptors in the innate recognition ofCandida albicans

Host response toCandida albicansbloodstream infection and sepsis

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