Absence of Tolerance to Hypotensive Effects of Clonidine in Spontaneously Hypertensive Rats

Naruse, Tomofumi; Ishii, Ritsuko; Tagawa, Takeshi

doi:10.1254/jjp.67.407

Cited by 8 publications

(2 citation statements)

References 15 publications

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“…All drugs were dissolved in distilled water and administered orally in the last 2 weeks of the ethanol administration period . The rilmenidine dose was 3 mg/kg/d, and the clonidine dose was 125 µg/kg/d …”

Section: Methodsmentioning

confidence: 99%

Effect of imidazoline‐1 receptor agonists on renal dysfunction in rats associated with chronic, sequential fructose and ethanol administration

Elkomy

Ibrahim

El-Fayoumi

et al. 2020

Clin Exp Pharma Physio

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Insulin resistance and chronic alcoholism are risk factors for renal dysfunction. This study investigated the therapeutic effects of two imidazoline‐1 receptor (I1R) agonists on renal dysfunction in rats after chronic, sequential fructose and ethanol administration. Daily drinking water was supplemented with fructose (10%, w/v) for 12 weeks and then with ethanol (20%, v/v) for another 8 weeks. Rats were treated with rilmenidine and clonidine in the last two weeks of the study. Blood glucose and serum insulin (sIns) levels, lipid profiles, kidney function and renal histopathology were evaluated at the end of the experiment. Additionally, renal gene expression of nischarin, phosphatidylcholine‐specific phospholipase C (PC‐PLC) and prostaglandin E2 (PGE2) were measured. Renal levels of superoxide dismutase (SOD), malondialdehyde (MDA), myeloperoxidase (MPO), inducible nitric oxide synthase (iNOS) and total NO (tNO) were detected, and we determined the relative renal gene expression levels of alpha smooth muscle actin (α‐SMA), hydroxyproline, interleukin 10 (IL‐10), tumour necrosis factor alpha (TNF‐α) and caspase‐3. The results showed significant deterioration of blood glucose, sIns, lipid profiles, kidney function and renal histopathology in fructose/ethanol‐fed rats. Additionally, markers of inflammation, fibrosis, apoptosis and oxidative stress were upregulated. The administration of rilmenidine or clonidine significantly improved blood glucose and sIns levels and reduced renal dysfunction. Our work showed that chronic, sequential fructose and ethanol administration induced fasting hyperglycaemia and renal impairment, and these effects were ameliorated by I1R agonists.

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Section: Methodsmentioning

confidence: 99%

Effect of imidazoline‐1 receptor agonists on renal dysfunction in rats associated with chronic, sequential fructose and ethanol administration

Elkomy

Ibrahim

El-Fayoumi

et al. 2020

Clin Exp Pharma Physio

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“…The reduction in BP induced by flesinoxan is due to selective stimulation of central 5-HT1A receptors leading to the reduction of sympathetic tone. [17][18][19] Because conflicting results have been reported on the chronic antihypertensive effects of clonidine in conscious SHR 20,21 and because no data are available on the chronic effects of flesinoxan, we investigated the effects of these drugs after both acute (24 h) and chronic (4 weeks) infusion. However, because the modifications of carotid artery diameter may be partly or totally independent of modifications in BP level, we used a low and high dose of each drug.…”

Section: Introductionmentioning

confidence: 99%

Acute And Chronic Sympathoinhibition On Carotid Artery Diameter Of Spontaneously Hypertensive Rats: Effects Of Clonidine And Flesinoxan

Dabiré

Chamiot-Clerc

Chaouche-Teyara

et al. 2000

Clin Exp Pharma Physio

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1. Hypertensive conduit arteries are thicker and stiffer than those of normotensive controls. Whether they are specifically sensitive to central sympathoinhibition has never been investigated. 2. The effects of acute (24 h infusion) and chronic (4 week infusion) treatments with clonidine (0.01 and 0.1 mg/kg per day) and flesinoxan (1 and 3 mg/kg per day) on carotid artery diameter were investigated in spontaneously hypertensive rats. At the end of treatment, blood pressure (BP) was recorded in the rats while they were conscious. Rats were then anaesthetized for carotid artery diameter measurements using an ultrasonic echotracking device. 3. In conscious rats, clonidine significantly decreased BP and heart rate (HR) following acute but not chronic treatment. In contrast, flesinoxan significantly decreased BP following both the acute and chronic treatment. In anaesthetized animals, the two agents have opposite effects on isobaric carotid artery diameter, with a decrease under clonidine and an increase under flesinoxan. After 4 weeks infusion, the reactivity of aortic rings was studied in organ chambers. Flesinoxan, but not clonidine, caused the relaxation of potassium chloride precontracted aortic segments. 4. The results indicate that although clonidine and flesinoxan are centrally acting antihypertensive agents, the drug-induced changes in isobaric carotid diameter may be influenced by local factors independent of the central action of the two drugs.

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Ameliorative effects of clonidine on ethanol induced kidney injury in rats: Potential role for imidazoline-1 receptor

Elkomy

Ibrahim

Elshazly

et al. 2018

European Journal of Pharmacology

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Absence of Tolerance to Hypotensive Effects of Clonidine in Spontaneously Hypertensive Rats

Cited by 8 publications

References 15 publications

Effect of imidazoline‐1 receptor agonists on renal dysfunction in rats associated with chronic, sequential fructose and ethanol administration

Effect of imidazoline‐1 receptor agonists on renal dysfunction in rats associated with chronic, sequential fructose and ethanol administration

Acute And Chronic Sympathoinhibition On Carotid Artery Diameter Of Spontaneously Hypertensive Rats: Effects Of Clonidine And Flesinoxan

Ameliorative effects of clonidine on ethanol induced kidney injury in rats: Potential role for imidazoline-1 receptor

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