Absence of transmission from HIV-infected individuals with HAART to their heterosexual serodiscordant partners

Romero, Jorge del; Río, Isabel; Castilla, Jesús; Baza, B.; Paredes, V.; Vera, Mar; Rodrı́guez, Carmen

doi:10.1016/j.eimc.2014.10.020

Cited by 11 publications

(11 citation statements)

References 24 publications

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“…We updated 2 reviews on use of antiretroviral therapy 6,21 that included the same 6 studies; 40,44-48 2 of those studies had more recent results identified through our update search. 49,50 Of 7266 citations screened in our update, 7 met our eligibility criteria. [49][50][51][52][53][54][55] Therefore, 11 studies (4 from the original reviews [44][45][46][47] and 7 from the update search [49][50][51][52][53][54][55] ) met the eligibility criteria (Supplementary Figure S2, Appendix 3).…”

Section: Resultsmentioning

confidence: 99%

“…Where there were 0 transmission events, the upper limits of the 95% CIs were solely a function of the studies' person-years of follow-up. 46,47,49,51,55 For Q3, the transmission risk a priori should be lower than with either antiretroviral therapy or condom use alone, although it does not meet the criteria from the Canadian AIDS Society for negligible risk. Some practices within a particular Canadian AIDS Society risk category may pose a lower risk than others (e.g., Q3 v. Q5).…”

Section: Discussionmentioning

confidence: 99%

“…The included studies reported 23 phylogenetically linked HIV transmissions across 10 511 person-years of follow-up on antiretroviral therapy (pooled incidence 0.22 transmissions/100 person-years, 95% CI 0.14-0.33). [44][45][46][47][49][50][51][52][53][54][55] Among heterosexual sex partners, there were 23 linked transmissions over 9922 person-years (pooled incidence 0.23 transmissions/100 person-years, 95% CI 0.15-0.35). [44][45][46][47]49,50,[52][53][54][55] We rated the quality of the evidence as high for heterosexual sex partners and as moderate for WSW because of the application of indirect evidence from heterosexual sex partners.…”

Section: Q1: the Hiv-positive Sex Partner Is Taking Antiretroviral Thmentioning

confidence: 99%

See 2 more Smart Citations

Risk of sexual transmission of human immunodeficiency virus with antiretroviral therapy, suppressed viral load and condom use: a systematic review

LeMessurier

Traversy

Varsaneux

et al. 2018

CMAJ

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Q1: the Hiv-positive Sex Partner Is Taking Antiretroviral Thmentioning

confidence: 99%

See 1 more Smart Citation

Risk of sexual transmission of human immunodeficiency virus with antiretroviral therapy, suppressed viral load and condom use: a systematic review

LeMessurier

Traversy

Varsaneux

et al. 2018

CMAJ

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“…The follow-up of this cohort allowed us to document the absence of HIV transmission from infected individuals with suppressive ART to their heterosexual SDCs. [2,5] Detailed data on sexual behavior are systematically collected in this cohort, [15] which has allowed us to document >7000 unprotected events of vaginal intercourse with ejaculation for the purpose of reproduction.…”

Section: Discussionmentioning

confidence: 99%

Natural conception in HIV-serodiscordant couples with the infected partner in suppressive antiretroviral therapy

et al. 2016

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The potential of antiretroviral treatment (ART) to prevent the sexual transmission of HIV has increased the number of serodiscordant couples who are considering natural conception. We aim to describe the results of a protocol for reproductive counseling aimed at HIV serodiscordant couples who desire natural conception, in which the infected partner, the index case, is receiving suppressive antiretroviral treatment.A prospective cohort included all HIV serodiscordant couples attended a counseling program in the period 2002 to 2013 who opted for natural conception and met the following criteria: index case on ART with persistent plasma viral suppression for at least the previous 6 months, ART compliance over 95%, preserved immune status, undetectable HIV viral and proviral load in semen in male index cases, and absence of genitourinary infections and fertility problems in both members of the couple.Of the 161 HIV serodiscordant couples included, 133 with male index cases, 66% achieved at least 1 pregnancy, 18% a second one, and 5% a third pregnancy. A total of 144 natural pregnancies occurred and 107 babies were born. The pregnancy rate was 1.9 for each 100 acts of vaginal intercourse, and the mean time to conception was 6.1 months, both independently of the sex of the index case. No case of sexual or vertical HIV transmission occurred.In the absence of fertility problems and under controlled conditions, natural conception might be a safe and effective reproductive method for those HIV serodiscordant couples who choose this reproductive option.

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“…Evidências atuais demonstram o impacto da TARV nessa redução para cerca de três vezes menos transmissão entre usuários regulares de TARV 26 . Segundo estimativas de Del Romero et al 27 , a transmissão horizontal chega a zero para casais sorodiscordantes quando o sujeito positivo para o HIV usa regularmente os antirretrovirais, tem carga viral A adaptação ao uso de condom feminina é uma barreira citada constantemente nos trabalhos sobre contracepção e sexo seguro, figurando sempre com baixas taxas de uso, mesmo entre infectados pelo HIV 28 . Nesta casuística, apenas três usuárias mantinham o método cotidianamente, a despeito de, no centro onde ocorreu o estudo, terem sido distribuídas 8.831 unidades de preservativo feminino entre 2011 e 2014, segundo controle de dispensação da farmácia da unidade.…”

Section: Discussionunclassified

Adesão à dupla contracepção entre mulheres infectadas pelo HIV

brandão¹,

Líma²,

Travassos³

et al. 2015

Rev. Bras. Ginecol. Obstet.

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(37/114). Relato de resistência do parceiro para usar preservativo em 30,7% (35/114). A dupla contracepção com AMPD e condom foi relatada por 42,9% (49/114). Resistência do parceiro para usar condom foi associada com má adesão (RP=0,3; IC95% 0,2-0,7; p<0,001). Parceiro desconhecer a infecção da parceira pelo HIV favoreceu a adesão (RP=1,8; IC95% 1,2-2,7; p=0,013). CONCLUSÃO: Neste estudo, adesão à dupla contracepção com AMPD e condom foi de 42,9%, mantendo gestações não planejadas e sexo desprotegido. Resistência do parceiro para usar condom aumenta três vezes a chance de a mulher não aderir à dupla proteção e parceiro desconhecer a infecção da mulher quase duplica a chance de ela aderir. Metas: ampliar oferta de novos contraceptivos e envolver parceiros na contracepção e testagem. Abstract PURPOSE:To determine adherence to dual contraception using depot-medroxyprogesterone acetate (DMPA) and condom among HIV-infected women. METHODS: A cross-sectional study carried out from December 2013 to September 2014 at a local reference center, with application of questionnaire elaborated after Delphi panel and content validation to 114 HIV(+) women aged 15 to 49 years, using DMPA plus condom for contraception.

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Absence of transmission from HIV-infected individuals with HAART to their heterosexual serodiscordant partners

Cited by 11 publications

References 24 publications

Risk of sexual transmission of human immunodeficiency virus with antiretroviral therapy, suppressed viral load and condom use: a systematic review

Risk of sexual transmission of human immunodeficiency virus with antiretroviral therapy, suppressed viral load and condom use: a systematic review

Natural conception in HIV-serodiscordant couples with the infected partner in suppressive antiretroviral therapy

Adesão à dupla contracepção entre mulheres infectadas pelo HIV

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