Absolute binding free energies of mucroporin and its analog mucroporin-M1 with the heptad repeat 1 domain and RNA-dependent RNA polymerase of SARS-CoV-2

Souza, Felipe Rodrigues de; Moura, Paloma Guimarães; Costa, Rayla Kelly Magalhães; Silva, Rudielson Santos; Pimentel, André Silva

doi:10.1080/07391102.2022.2114014

Cited by 3 publications

(1 citation statement)

References 71 publications

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“…As a title of example, ACE2-blocker mucroporin-M1 (LFRLIKSLIKRLVSAFK, Figure 9) is an engineered peptide analogue carrying four residual mutations with respect to the parent peptide, mucroporin, isolated from the venom of the scorpion Lychas mucronatus. As molecular blocker, mucroporin-M1 binds to the ACE2 receptor, allowing for the rupture of the viral envelope [45,46]. Another ACE2-blocker is the natural peptide similar to human lectin-defensin-5 (HD5) (ATCYCRT-GRCATRESLSGVCEISGRLYRLCCR), secreted by Paneth cells in Lieberkuhn crypts [46].…”

Section: Antiviral Drugsmentioning

confidence: 99%

Peptides as Therapeutic Agents: Challenges and Opportunities in the Green Transition Era

Rossino,

Marchese,

Galli

et al. 2023

Molecules

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Peptides are at the cutting edge of contemporary research for new potent, selective, and safe therapeutical agents. Their rise has reshaped the pharmaceutical landscape, providing solutions to challenges that traditional small molecules often cannot address. A wide variety of natural and modified peptides have been obtained and studied, and many others are advancing in clinical trials, covering multiple therapeutic areas. As the demand for peptide-based therapies grows, so does the need for sustainable and environmentally friendly synthesis methods. Traditional peptide synthesis, while effective, often involves environmentally draining processes, generating significant waste and consuming vast resources. The integration of green chemistry offers sustainable alternatives, prioritizing eco-friendly processes, waste reduction, and energy conservation. This review delves into the transformative potential of applying green chemistry principles to peptide synthesis by discussing relevant examples of the application of such approaches to the production of active pharmaceutical ingredients (APIs) with a peptide structure and how these efforts are critical for an effective green transition era in the pharmaceutical field.

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Section: Antiviral Drugsmentioning

confidence: 99%