Absolute configurations of integracins A, B, and 15′‐dehydroxy‐integracin B

Liu, Haili; Huang, Xiao-Yin; Li, Jia; Xin, Guorong; Guo, Yue‐Wei

doi:10.1002/chir.22012

Cited by 17 publications

(15 citation statements)

References 17 publications

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“…38 However, we only detected A. penicillioides from one sample with culturing and 13.6% of samples with DNA sequencing. Integracin B was more prevalent than A (93% vs 71%), and they are produced by the endophyte, Cytonaema species 39 and Cytospora species 40 which were not identified in our samples. Alternariol MME, which has been also found in tobacco, grain sorghum and pecans, are produced by Alternaria tenuis, Alternaria dauci and Alternaria cucumerina.…”

Section: Citreorosein Emodin Alternariol Mme Integracin a Integracin contrasting

confidence: 57%

Characterization of fungi in office dust: Comparing results of microbial secondary metabolites, fungal internal transcribed spacer region sequencing, viable culture and other microbial indices

et al. 2018

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Recent developments in molecular and chemical methods have enabled the analysis of fungal DNA and secondary metabolites, often produced during fungal growth, in environmental samples. We compared 3 fungal analytical methods by analysing floor dust samples collected from an office building for fungi using viable culture, internal transcribed spacer (ITS) sequencing and secondary metabolites using liquid chromatography-tandem mass spectrometry. Of the 32 metabolites identified, 29 had a potential link to fungi with levels ranging from 0.04 (minimum for alternariol monomethylether) to 5700 ng/g (maximum for neoechinulin A). The number of fungal metabolites quantified per sample ranged from 8 to 16 (average = 13/sample). We identified 216 fungal operational taxonomic units (OTUs) with the number per sample ranging from 6 to 29 (average = 18/sample). We identified 37 fungal species using culture, and the number per sample ranged from 2 to 13 (average = 8/sample). Agreement in identification between ITS sequencing and culturing was weak (kappa = -0.12 to 0.27). The number of cultured fungal species poorly correlated with OTUs, which did not correlate with the number of metabolites. These suggest that using multiple measurement methods may provide an improved understanding of fungal exposures in indoor environments and that secondary metabolites may be considered as an additional source of exposure.

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Section: Citreorosein Emodin Alternariol Mme Integracin a Integracin contrasting

confidence: 57%

Characterization of fungi in office dust: Comparing results of microbial secondary metabolites, fungal internal transcribed spacer region sequencing, viable culture and other microbial indices

et al. 2018

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“…Previously, pharmaceutical investigations on Sonneratia genus showed antidiabetic, antioxidant, antibacterial, and anti‐tumor properties …”

Section: Introductionmentioning

confidence: 99%

Structure elucidation of four new megastigmanes from Sonneratia ovata Backer

Nguyen

Pham

Pudhom

et al. 2014

Magnetic Reson in Chemistry

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“…Upon publication, the article was immediately covered in the journal of Natural Product Reports as "hot off the press" [24] . In addition, three known compounds, integracins A and B (21 and 22) and 15-dehydroxy-integracin B (24), were isolated for the first time from the Chinese mangrove plant Sonneratia hainanensis [25] ( Figure 5). Although compounds 21-24 had been reported previously, their absolute configurations were not resolved until their absolute chemistry was determined using Mosher's method, the specific rotation analysis of the alcohols (24 and 25) obtained from integracin A (21) in two steps, and chemical correlation.…”

Section: Chemical Studies On Chinese Marine Plantsmentioning

confidence: 99%

Bioactive natural products from Chinese marine flora and fauna

Zhou

Guo

2012

Acta Pharmacol Sin

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In recent decades, the pharmaceutical application potential of marine natural products has attracted much interest from both natural product chemists and pharmacologists. Our group has long been engaged in the search for bioactive natural products from Chinese marine flora (such as mangroves and algae) and fauna (including sponges, soft corals, and mollusks), resulting in the isolation and characterization of numerous novel secondary metabolites spanning a wide range of structural classes and various biosynthetic origins. Of particular interest is the fact that many of these compounds show promising biological activities, including cytotoxic, antibacterial, and enzyme inhibitory effects. By describing representative studies, this review presents a comprehensive summary regarding the achievements and progress made by our group in the past decade. Several interesting examples are discussed in detail.

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Absolute configurations of integracins A, B, and 15′‐dehydroxy‐integracin B

Cited by 17 publications

References 17 publications

Characterization of fungi in office dust: Comparing results of microbial secondary metabolites, fungal internal transcribed spacer region sequencing, viable culture and other microbial indices

Characterization of fungi in office dust: Comparing results of microbial secondary metabolites, fungal internal transcribed spacer region sequencing, viable culture and other microbial indices

Structure elucidation of four new megastigmanes from Sonneratia ovata Backer

Bioactive natural products from Chinese marine flora and fauna

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