2022
DOI: 10.1007/s13300-022-01347-4
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Absolute Hyperglycemia versus Stress Hyperglycemia Ratio for the Prognosis of Hospitalized Patients with COVID-19 in the First Months of the Pandemic: A Retrospective Study

Abstract: Diabetes is a risk factor for greater severity of coronavirus disease 2019 (COVID-19). The stress hyperglycemia ratio (SHR) is an independent predictor of critical illness, and it is reported to have a stronger association than absolute hyperglycemia. The aim of this study was to assess the relationship of absolute hyperglycemia and SHR with the severity of COVID-19, since there are no studies investigating SHR in patients with COVID-19. We conducted a retrospective observational study on hospitalized patients… Show more

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Cited by 3 publications
(4 citation statements)
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“…The prognostic importance of hyperglycaemia on the outcomes of COVID-19 infection has been emphasized in multiple studies. Hyperglycaemia atadmission in patients without diabetes is associated with a higher incidence of a severe course of COVID-19 infection, need for IMV, admission to the ICU [10][11][12][24][25][26][27][28][29][30], and higher mortality [13,14,27,29,31,32].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The prognostic importance of hyperglycaemia on the outcomes of COVID-19 infection has been emphasized in multiple studies. Hyperglycaemia atadmission in patients without diabetes is associated with a higher incidence of a severe course of COVID-19 infection, need for IMV, admission to the ICU [10][11][12][24][25][26][27][28][29][30], and higher mortality [13,14,27,29,31,32].…”
Section: Discussionmentioning
confidence: 99%
“…Hyperglycaemia is associated with a higher incidence of a severe course of COVID-19 infection, including the need for oxygen therapy [10,11], invasive mechanical ventilation (IMV) [10,11], and admission to the intensive care unit (ICU) [10][11][12] and has been found to be a predictor of in-hospital mortality in COVID-19 patients [12][13][14][15].…”
Section: Introductionmentioning
confidence: 99%
“…In this retrospective, single-centre study, 252 patients were included with COVID-19, aged 17-97 years; 133 males and 119 females were treated at the General Hospital of Central Theatre Command from December 2019 to February 2020. Diagnostic criteria: The diagnostic criteria for stress hyperglycaemia were fasting blood glucose ≥ 7.78 mmol/L along with glycated haemoglobin (HbA 1c ) < 6.5% [13,14]. The diagnosis of COVID-19 was based on the pneumonia diagnosis protocol for novel coronavirus infection promulgated by the Health Care Commission of the People's Republic of China [15].…”
Section: Methodsmentioning
confidence: 99%
“…DM can weaken the immune system through various mechanisms, including poor chronic glycemic control as well as acute hyperglycemia [ 15 , 16 ]. Hyperglycemia upon admission has been proven to be a major predictor of death and severe sequelae in COVID-19 [ 17 ]—although the same does not apply to stress hyperglycemia [ 18 ]; however, the SARS-CoV-2 infection can induce hyperglycemia and reveal newly onset diabetes [ 19 ]. In addition, oxidative stress and the production of adhesion molecules that mediate inflammation in the tissue, in combination with the binding of SARS-CoV-2 to ACE-2 receptors expressed in the cells of the pancreas, adipose tissue, and intestine might cause alterations in glucose metabolism and contribute to the augmented severity of COVID-19 [ 20 , 21 , 22 ].…”
Section: Introductionmentioning
confidence: 99%