Absolute Leukocyte Telomere Length in HIV-Infected and Uninfected Individuals: Evidence of Accelerated Cell Senescence in HIV-Associated Chronic Obstructive Pulmonary Disease

Liu, Joseph C. Y.; Leung, Janice M.; Ngan, David A.; Nashta, Negar F.; Guillemi, Silvia; Harris, Marianne; Lima, Viviane D.; Um, Soo-Jung; Yue-xin, LI; Tam, Sheena; Shaipanich, Tawimas; Raju, Rekha; Hague, Cameron; Leipsic, Jonathon; Bourbeau, Jean; Tan, Wan C.; Harrigan, P. Richard; Sin, Don D.; Montaner, Julio S. G.; Man, S. F. Paul

doi:10.1371/journal.pone.0124426

Cited by 62 publications

(54 citation statements)

References 32 publications

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“…Ultimately, a critical telomere length is reached whereby cell proliferation ceases and apoptosis ensues. We have previously demonstrated that peripheral leukocyte telomere lengths in PLWH are significantly shorter than in HIV-negative control subjects, with the severity of lung function as measured by forced expiratory volume in 1 second (FEV1) correlating with decreased telomere length [4]. In this study, we further these findings by determining whether advanced replicative senescence can also be observed within the lungs of PLWH.…”

Section: To the Editormentioning

confidence: 69%

Decreased telomere length in the small airway epithelium suggests accelerated aging in the lungs of persons living with human immunodeficiency virus (HIV)

Vucic

Shaipanich

et al. 2018

Respir Res

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Human immunodeficiency virus (HIV) infection is associated with an increased risk of chronic obstructive pulmonary disease (COPD) independent of cigarette smoke exposure. Previous studies have demonstrated that decreased peripheral leukocyte telomere length is associated with HIV, suggesting an accelerated aging phenomenon. We demonstrate that this process of telomere shortening also occurs in the lungs, with significant decreases in telomere length observed in small airway epithelial cells collected during bronchoscopy. Molecular evidence of accelerated aging in the small airway epithelium of persons living with HIV may be one clue into the predisposition for chronic lung disease observed in this population.

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Section: To the Editormentioning

confidence: 69%

Decreased telomere length in the small airway epithelium suggests accelerated aging in the lungs of persons living with human immunodeficiency virus (HIV)

Vucic

Shaipanich

et al. 2018

Respir Res

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“…The relationship of HIV infection to several biological aging-related pathophysiologic pathways has provided some support for this hypothesis [57–60]. Conversely, several recent epidemiologic studies provide support for an accentuated rather than accelerated aging-related process in the HIV-infected population, with no difference in the mean age at onset of several aging-related disease conditions between HIV-infected and uninfected persons [61, 62].…”

Section: Introductionmentioning

confidence: 99%

Frailty in HIV: Epidemiology, Biology, Measurement, Interventions, and Research Needs

2016

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Frailty is a critical aging-related syndrome marked by diminished physiologic reserve and heightened vulnerability to stressors, predisposing to major adverse clinical outcomes, including hospitalization, institutionalization, disability, and death in the general population of older adults. As the proportion of older adults living with HIV increases in the era of antiretroviral therapy, frailty is increasingly recognized to be of significant clinical and public health relevance to the HIV-infected population. This article reviews current knowledge on the epidemiology and biology of frailty and its potential role as a target for reducing disparities in outcomes in HIV; conceptual frameworks and current approaches to frailty measurement; existing data on frailty interventions; and important areas for future research focus necessary to develop and advance effective strategies to prevent or ameliorate frailty and its marked adverse consequences among people living with HIV.

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“…Prior studies have identified biomarkers (e.g., soluble CD14, leukocyte telomere length) which may correlate with radiographic changes in HIV. 10,26 We do not have biomarker data to determine how levels of lung inflammation correlate with CT findings and HIV status. Currently, longitudinal CT scan data is not available to determine how CT findings may progress over time.…”

Section: Discussionmentioning

confidence: 99%

HIV Infection Is Independently Associated with Increased CT Scan Lung Density

et al. 2017

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Rationale and Objectives Non-infectious pulmonary complications are common among HIV-infected individuals and may be detected early by quantitative CT scan. The association of HIV disease markers with CT lung density measurement remains poorly understood. Materials and Methods 125 participants free of spirometry-defined lung disease were recruited from a longitudinal cohort study of HIV-infected and HIV negative individuals to undergo standardized CT scan of the chest. Parenchymal densities for the entire lung volumes wer calculated using computerized software. Qualitative assessment of CT scans was conducted by two radiologists masked to HIV status. Linear regression models were developed to determine the independent association of markers of HIV infection on inspiratory scan mean lung density (MLD). Results HIV-infected participants had a significantly higher MLD (denser lung) compared with HIV-uninfected participants (−815 vs. −837 HU; p=0.002). After adjusting for relevant covariates, HIV infection was independently associated with 19.9 HU higher MLD (95% CI 6.04 to 33.7 HU; p=0.005). In qualitative assessment, only ground glass attenuation and cysts were noted more commonly among HIV-infected individuals compared with HIV-uninfected individuals [34% versus 17% (p=0.045) and 27% versus 10% (p=0.03), respectively]. No qualitative radiographic abnormalities attenuated the association between HIV infection and increased MLD. Conclusions HIV infection is independently associated with increased lung density. Although qualitative CT abnormalities were common in this cohort, only ground glass attenuation and cysts were noted more frequently in HIV-infected participants, suggesting that the increased lung density observed among HIV-infected individuals may be associated with subclinical inflammatory lung changes.

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Absolute Leukocyte Telomere Length in HIV-Infected and Uninfected Individuals: Evidence of Accelerated Cell Senescence in HIV-Associated Chronic Obstructive Pulmonary Disease

Cited by 62 publications

References 32 publications

Decreased telomere length in the small airway epithelium suggests accelerated aging in the lungs of persons living with human immunodeficiency virus (HIV)

Decreased telomere length in the small airway epithelium suggests accelerated aging in the lungs of persons living with human immunodeficiency virus (HIV)

Frailty in HIV: Epidemiology, Biology, Measurement, Interventions, and Research Needs

HIV Infection Is Independently Associated with Increased CT Scan Lung Density

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