Absolute monocyte and lymphocyte count prognostic score for patients with gastric cancer

Eo, Wan Kyu; Jeong, Dawoon; Chang, Ho‐Wan; Won, Kyu Yeoun; Choi, Sung Il; Kim, Se Hyun; Chun, Sung Wook; Oh, Young Lim; Lee, Tae Wha; Kim, Young Ok; Kim, Ki Hyung; Ji, Yong; Kim, Ari; Kim, Heung Yeol

doi:10.3748/wjg.v21.i9.2668

Cited by 56 publications

(46 citation statements)

References 33 publications

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“…The prognostic significance of peripheral lymphocyte counts in various kinds of cancers has been reported. 4,23,24 Lymphocytes play important roles in antitumor immunity, inducing apoptosis, and suppressing tumor proliferation. Cytotoxic T cells and natural killer cells, both derived from T lymphocytes, exhibit antitumor activities of inhibiting the growth and metastasis of tumor.…”

Section: Discussionmentioning

confidence: 99%

Significance of Monocyte Counts at Recurrence on Survival Outcome of Women With Endometrial Cancer

Machida

Zoysa

Takiuchi

et al. 2017

Int J Gynecol Cancer

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Section: Discussionmentioning

confidence: 99%

Significance of Monocyte Counts at Recurrence on Survival Outcome of Women With Endometrial Cancer

Machida

Zoysa

Takiuchi

et al. 2017

Int J Gynecol Cancer

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“…Until now, various indexes have been offered to assess the nutritional status in cancer patients (8,9,22,23). All the assessment indexes have their own merits, but they have also raised a series of questions.…”

Section: Discussionmentioning

confidence: 99%

Prognostic nutritional index is an independent prognostic factor for gastric cancer patients with peritoneal dissemination

Nie¹,

Yuan²,

Chen³

et al. 2016

Chinese Journal of Cancer Research

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ObjectiveThe predictive and prognostic role of prognostic nutritional index (PNI) in gastric cancer patients with peritoneal dissemination remains unclear. This study aims to explore the role of the PNI in predicting outcomes of gastric cancer patients with peritoneal dissemination.MethodsA total of 660 patients diagnosed with gastric adenocarcinoma with peritoneal metastasis between January 2000 and April 2014 at Sun Yat-sen University Cancer Center and the Sixth Affiliated Hospital of Sun Yat-sen University were retrospectively analyzed. The clinicopathologic characteristics and clinical outcomes of patients with peritoneal dissemination were analyzed.ResultsCompared with PNI-high group, PNI-low group was correlated with advanced age (P=0.036), worse performance status (P<0.001), higher frequency of ascites (P<0.001) and higher frequency of multisite distant metastasis (P<0.001). Kaplan-Meier survival curves showed that PNI-high group had a significantly longer median overall survival than PNI-low group (13.13 vs. 9.03 months, P<0.001). Multivariate survival analysis revealed that Borrmann type IV (P=0.014), presence of ascites (P=0.017) and lower PNI (P=0.041) were independent poor prognostic factors, and palliative surgery (P<0.001) and first-line chemotherapy (P<0.001) were good prognostic factors. For patients receiving palliative surgery, the postoperative morbidity rates in the PNI-low group and PNI-high group were 9.1% and 9.9%, respectively (P=0.797). The postoperative mortality rate was not significantly different between PNI-low and PNI-high groups (2.3% vs. 0.9%, P=0.362). ConclusionsPNI is a useful and practical tool for evaluating the nutritional status of gastric cancer patients with peritoneal dissemination, and is an independent prognostic factor for these patients.

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“…In various solid and hematologic malignancies, the circulating absolute monocyte count (AMC) at the time of diagnosis has prognostic significance [7–13]. In CLL, such work has not fully evaluated the relevance of AMC with other routinely used prognostic markers in the context of large patient cohorts.…”

Section: Introductionmentioning

confidence: 99%

Relationship of blood monocytes with chronic lymphocytic leukemia aggressiveness and outcomes: a multi‐institutional study

et al. 2016

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Background Monocyte-derived cells, constituents of the cancer microenvironment, support chronic lymphocytic leukemia (CLL) cell survival in vitro via direct cell-cell interaction and secreted factors. We hypothesized that circulating absolute monocyte count (AMC) reflects the monocyte-derived cells in the microenvironment, and that higher AMC is associated with increased CLL cell survival in vivo and thus inferior CLL patient outcomes. Methods We assessed the extent to which AMC at diagnosis of CLL is correlated with clinical outcomes, and whether this information adds to currently used prognostic markers. We evaluated AMC, clinically used prognostic markers, and time to event data from 1,168 CLL patients followed at the Mayo Clinic, the Duke University Medical Center, and the Durham VA Medical Center. Results Elevated AMC was significantly associated with inferior clinical outcomes, including time to first therapy (TTT) and overall survival (OS). AMC combined with established clinical and molecular prognostic markers significantly improved risk-stratification of CLL patients for TTT. Conclusions Elevated AMC at diagnosis is associated with inferior CLL patient outcomes and accelerated disease progression. Monocyte-derived cells in the CLL microenvironment promote CLL cell survival and proliferation. Together, these findings suggest that monocytes and monocyte-derived cells are rational therapeutic targets in CLL.

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Absolute monocyte and lymphocyte count prognostic score for patients with gastric cancer

Abstract: AMLPS identified patients with a poor DFS and OS, and it was independent of age, pathologic stage, and various inflammatory markers.

Cited by 56 publications

References 33 publications

Significance of Monocyte Counts at Recurrence on Survival Outcome of Women With Endometrial Cancer

Significance of Monocyte Counts at Recurrence on Survival Outcome of Women With Endometrial Cancer

Prognostic nutritional index is an independent prognostic factor for gastric cancer patients with peritoneal dissemination

Relationship of blood monocytes with chronic lymphocytic leukemia aggressiveness and outcomes: a multi‐institutional study

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