Absolute quantification of resting oxygen metabolism and metabolic reactivity during functional activation using QUO2 MRI

Gauthier, Claudine; Desjardins-Crépeau, Laurence; Madjar, Cécile; Bherer, Louis; Hoge, Richard D.

doi:10.1016/j.neuroimage.2012.07.065

Cited by 70 publications

(92 citation statements)

References 81 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With the recent early termination of this trial, there has been renewed interest in the predictive value of OEF increase because some authors 6 have attributed the trial's futility to methodologic failure of the OEF PET selection criteria. In addition, with multiple MR imaging-based surrogate measures of OEF being developed with techniques such as susceptibility-weighted MR imaging, 10 functional MR imaging, 11 and MR spectroscopy, 12 it is important to summarize the value of OEF as a reference standard to predict stroke by which future technologies can be assessed. If shown to be accurate markers of cerebral oxygen metabolism compared with PET-derived OEF, these potentially more widely available MR imaging techniques can then be tested as potential stroke risk prediction tools.…”

Section: Discussionmentioning

confidence: 99%

“…The role of OEF in stroke risk prediction also deserves renewed attention, given its potential value as a reference standard for new MR imaging measures of brain oxygen metabolism. [10][11][12] Some of the difficulties in drawing definite conclusions about the role of OEF in predicting stroke and its role in treating patients with carotid disease are based on small sample sizes in individual research studies on this topic and the heterogeneity of study designs implemented. For this reason, and in the light of several recently published studies 5,9 following patients after OEF PET testing, a critical reappraisal of the OEF literature is warranted.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Oxygen Extraction Fraction and Stroke Risk in Patients with Carotid Stenosis or Occlusion: A Systematic Review and Meta-Analysis

Gupta¹,

Baradaran²,

Schweitzer³

et al. 2013

American Journal of Neuroradiology

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Oxygen Extraction Fraction and Stroke Risk in Patients with Carotid Stenosis or Occlusion: A Systematic Review and Meta-Analysis

Gupta¹,

Baradaran²,

Schweitzer³

et al. 2013

American Journal of Neuroradiology

View full text Add to dashboard Cite

show abstract

“…Several fMRI methods have been developed to recover baseline CMRO 2 . One of these methods is an extension of calibrated fMRI with both hypercapnia and hyperoxia [14][15][16]. This method has recently been refined using a compartmental BOLD model [66].…”

Section: (D) Linking Microscopic To Macroscopic Parametersmentioning

confidence: 99%

Validation and optimization of hypercapnic-calibrated fMRI from oxygen-sensitive two-photon microscopy

Gagnon

Sakadžić

Lesage

et al. 2016

Phil. Trans. R. Soc. B

View full text Add to dashboard Cite

One contribution of 15 to a Theo Murphy meeting issue 'Interpreting BOLD: a dialogue between cognitive and cellular neuroscience'. LG, 0000-0001-7202-5176Hypercapnic-calibrated fMRI allows the estimation of the relative changes in the cerebral metabolic rate of oxygen (rCMRO 2 ) from combined BOLD and arterial spin labelling measurements during a functional task, and promises to permit more quantitative analyses of brain activity patterns. The estimation relies on a macroscopic model of the BOLD effect that balances oxygen delivery and consumption to predict haemoglobin oxygenation and the BOLD signal. The accuracy of calibrated fMRI approaches has not been firmly established, which is limiting their broader adoption. We use our recently developed microscopic vascular anatomical network model in mice as a ground truth simulator to test the accuracy of macroscopic, lumped-parameter BOLD models. In particular, we investigate the original Davis model and a more recent heuristic simplification. We find that these macroscopic models are inaccurate using the originally defined parameters, but that the accuracy can be significantly improved by redefining the model parameters to take on new values. In particular, we find that the parameter a that relates cerebral blood-volume changes to cerebral blood-flow changes is significantly smaller than typically assumed and that the optimal value changes with magnetic field strength. The results are encouraging in that they support the use of simple BOLD models to quantify BOLD signals, but further work is needed to understand the physiological interpretation of the redefined model parameters. This article is part of the themed issue 'Interpreting BOLD: a dialogue between cognitive and cellular neuroscience'.

show abstract

“…Though CT perfusion and T2* dynamic susceptibility contrast MRI perfusion are well-established methods of studying CBF, because cerebrovascular reserve testing requires two separate measurements of CBF (both at rest and after a vasodilatory stimulus), the need to administer two separate contrast doses may limit the role of contrast-enhanced perfusion imaging for cerebrovascular reserve testing. Arterial spin labeling MRI and blood-oxygen-level dependent (BOLD) functional MRI (fMRI) are potentially more attractive blood flow measurement techniques that have been recently shown to be accurate and feasible methods of cerebrovascular reserve testing that can be repeated without the need for intravenous contrast administration [77,78,79,80,81,82,83]. Future prospective observational studies will be needed to determine whether these MRI perfusion techniques can play a role in the prediction of ipsilateral ischemic stroke in asymptomatic carotid stenosis.…”

Section: Future Directions In Stroke Risk Assessment Studiesmentioning

confidence: 99%

“…Similarly, recent investigations have shown that MRI-based techniques can quantify brain cerebral metabolic rate of oxygen and oxygen extraction fraction, which could replace invasive PET techniques by allowing noninvasive measurement of brain oxygen metabolism via standard MRI equipment. Recent studies with susceptibility weighted imaging techniques [84,85] and fMRI BOLD [78,86] for example, have shown the feasibility of novel methods of oxygen metabolism quantification with MRI, though future investigations with carotid stenosis subjects are still needed to assess the clinical utility of these approaches.…”

Section: Future Directions In Stroke Risk Assessment Studiesmentioning

confidence: 99%

Moving Beyond Luminal Stenosis: Imaging Strategies for Stroke Prevention in Asymptomatic Carotid Stenosis

Gupta¹,

Marshall

2015

Cerebrovasc Dis

View full text Add to dashboard Cite

Background: With progressive improvements in medical therapy and resultant reductions in stroke risk, luminal stenosis criteria are no longer adequate to inform decisions to pursue surgical revascularization in patients with asymptomatic carotid artery stenosis. Summary: In this evidence-based review, we discuss the imaging-based risk stratification strategies that take into account factors beyond luminal stenosis measurements, including cerebral hemodynamics and plaque composition. The existing literature lends support to the use of certain imaging tests in patients with asymptomatic carotid stenosis including cerebrovascular reserve testing, MRI of plaque composition, ultrasound of plaque echolucency, and transcranial Doppler evaluation for microemboli. The highest quality evidence thus far in the literature includes only systematic reviews and meta-analyses of cohort studies with no randomized trials having yet been performed to show how these newer imaging biomarkers could be used to inform treatment decisions in asymptomatic carotid stenosis. Beyond the need for randomized trials, there are additional important steps needed to improve the relevance of evidence supporting risk assessment strategies. Imaging studies evaluating the risk of stroke in carotid disease should clearly define asymptomatic versus symptomatic disease, use uniform definitions of clearly defined outcome measures such as ipsilateral stroke, ensure that imaging interpretations are performed in a manner blinded to treatments and other risk factors, and include cohorts which are on modern intensive medical therapy. Such studies of risk stratification for asymptomatic carotid stenosis will be most valuable if they can integrate multiple high-risk features (including clinical risk factors) into a multi-factorial risk assessment strategy in a manner that is relatively simple to implement and generalizable across a wide range of practice settings. Key Messages: Together, modern imaging strategies allow for a more mechanistic assessment of stroke risk in carotid disease compared to luminal stenosis measurements alone, which, with further validation in randomized controlled trials, may improve current efforts at stroke prevention in asymptomatic carotid stenosis.

show abstract

Absolute quantification of resting oxygen metabolism and metabolic reactivity during functional activation using QUO2 MRI

Cited by 70 publications

References 81 publications

Oxygen Extraction Fraction and Stroke Risk in Patients with Carotid Stenosis or Occlusion: A Systematic Review and Meta-Analysis

Oxygen Extraction Fraction and Stroke Risk in Patients with Carotid Stenosis or Occlusion: A Systematic Review and Meta-Analysis

Validation and optimization of hypercapnic-calibrated fMRI from oxygen-sensitive two-photon microscopy

Moving Beyond Luminal Stenosis: Imaging Strategies for Stroke Prevention in Asymptomatic Carotid Stenosis

Contact Info

Product

Resources

About