Absolute three-dimensional measurement of refractive index via dual Brillouin spectroscopy (Conference Presentation)

Fiore, Antonio; Scarcelli, Giuliano

doi:10.1117/12.2510406

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“…Antonio Fiore from Dr. Scarcelli's group at the University of Maryland, USA, pointed out that the Brillouin shift, which is measured in Brillouin spectroscopy experiments, is related to high-frequency elastic modulus via the refractive index. 11 Thus Dr. Scarcelli's group advocated for high-precision refractive index measurements and discussed a newly developed confocal microscopy technique that can map the refractive index of samples in an absolute manner, with three-dimensional (3-D) resolution. 12 The unique experimental arrangement permits the same optical axis to be probed with two scattering geometries for Brillouin and elastic scattering, within a confocal voxel.…”

Section: Novel Methods In Elastographymentioning

confidence: 99%

Optical elastography and tissue biomechanics

2019

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Mechanical forces play an important role in the behavior and development of biological systems and disease at all spatial scales, from cells and their constituents to tissues and organs. Such forces have a profound influence on the health, structural integrity, and normal function of cells and organs. Accurate knowledge of cell and tissue biomechanical properties is essential to map the distribution of forces and mechanical cues in biological systems. Cell and tissue biomechanical properties are also known to be important on their own as indicators of health or disease states. Hence, optical elastography and biomechanics methods can aid in the understanding and clinical diagnosis of a wide variety of diseases. We provide a brief overview and highlight of the Optical Elastography and Tissue Biomechanics VI conference, which took place in San Francisco, February 2 and 3, 2019, as a part of Photonics West symposium.

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Section: Novel Methods In Elastographymentioning

confidence: 99%