Absorbable suture can be effectively and safely used to close the mesenteric defect in a gastric bypass Sprague-Dawley Rat Model

Abstract

Background: To observe if absorbable suture can effectively and safely be used to close the mesenteric defect after Roux-en-Y reconstruction. Methods: Rats were randomly assigned to 5 experimental groups according to different suture materials used in closing the mesenteric defects (Peterson’s space) after Roux-en-Y gastric bypass. Group A (control group), Group B (non-absorbable suture, Prolene suture), Group C (biological glue), Group D (non-absorbable suture, polyester suture) and Group E (absorbable suture). All rats were followed up for 8 weeks postoperatively and underwent laparotomy to observe the degree of adhesion and closure of the mesenteric defect. Results: No significant difference was found in the decrease in food intake and body weight among all groups. No internal hernia (IH) occurred in any group. The mesenteric defects of Group A remained completely visible without any closure or adhesion. Multiple gaps were found between Prolene suture and the mesentery along the suture line in Group B. The mesenteric defects of Group C were complete closed with multiple adhesions of the small intestine and the greater omentum. The mesenteric defects had closed completely in both Group D and Group E. Average adhesion score of Group A and Group B was 0 and 0.33±0.52 respectively. Average adhesion score was higher in group C (3.83±0.41) than the other groups (p＜0.05). Group D and E had similar average adhesion score, 3.17±0.41 and 3.00±0.00 respectively. Conclusion: Absorbable sutures can be effectively and safely used to close the mesenteric defect in a rat model.

The Use of Surgical Threads in Kidney Surgery

“…Patients in poor health may have a higher risk of infection, affecting the healing process and the time it takes for sutures to dissolve. Infections may delay healing and require additional interventions, such as removing or replacing sutures [62].…”

“…Although these factors may influence the duration of absorbable sutures in renal surgery, the choice of suture material and surgical technique also plays a critical role in the overall success of the procedure [62].…”

“…Premature destruction or dissolution of absorbable threads can lead to the separation of sutures when the surgical wound is reopened. This complication may require additional surgery to close the wound and may prolong the healing process [62].…”

“…Пацієнти з ослабленим здоров'ям можуть мати вищий ризик інфікування, що може вплинути на процес загоєння і тривалість розсмоктування швів. Інфекції можуть затримати загоєння і вимагати додаткових втручань, таких як зняття або заміна швів [62].…”

“…Хоча ці фактори можуть впливати на тривалість розсмоктувальних швів у хірургії нирок, вибір шовного матеріалу та хірургічної техніки також відіграють вирішальну роль у загальному успіху процедури [62].…”