Absorbed radiation doses due to chronic ingestion of cesium-137 or strontium-90 by mice

Bertho, Jean-Marc; Synhaeve, Nicholas; Miloudi, H.; Stéfani, Johanna; Desbrée, Aurélie; Blanchardon, E.; Dublineau, Isabelle

doi:10.1051/radiopro/2011161

Cited by 11 publications

(14 citation statements)

References 20 publications

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“…Although the number of organs used for 137 Cs measurements were limited, the results were in agreement with previous biokinetics experiments using a similar exposure schedule [32]. Thus, based on previously published biokinetics data [32] and using dose conversion factors proposed by ICRP publication 108 [40, 41], the mean absorbed radiation dose was estimated at 4.4 ± 1.3 mGy for the adult model in these previous experiments. The absorbed radiation doses in the postnatal model and in the in utero models were slightly higher.…”

Section: Resultssupporting

confidence: 87%

“…In fact, the estimated absorbed radiation dose during the lactation period was 0.30 ± 0.05 mGy, based again on these previous experiments [32]. Regarding the in utero period, a previous study showed that 85% of the absorbed radiation dose was due to the 137 Cs burden of the mother [41]. The estimated absorbed radiation dose during the in utero period was thus 0.96 ± 0.15 mGy.…”

Section: Resultsmentioning

confidence: 60%

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Chronic exposure of adult, postnatal and in utero rat models to low-dose 137Cesium: impact on circulating biomarkers

Manens¹,

Grison²,

Bertho³

et al. 2016

Journal of Radiation Research

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The presence of 137Cesium (137Cs) in the environment after nuclear accidents at Chernobyl and more recently Fukushima Daiichi raises many health issues for the surrounding populations chronically exposed through the food chain. To mimic different exposure situations, we set up a male rat model of exposure by chronic ingestion of a 137Cs concentration likely to be ingested daily by residents of contaminated areas (6500 Bq.l−1) and tested contaminations lasting 9 months for adult, neonatal and fetal rats. We tested plasma and serum biochemistry to identify disturbances in general indicators (lipids, proteins, carbohydrates and electrolytes) and in biomarkers of thyroid, heart, brain, bone, kidney, liver and testis functions. Analysis of the general indicators showed increased levels of cholesterol (+26%), HDL cholesterol (+31%), phospholipids B (+15%) and phosphorus (+100%) in the postnatal group only. Thyroid, heart, brain, bone and kidney functions showed no blood changes in any model. The liver function evaluation showed changes in total bilirubin (+67%) and alkaline phosphatase (–11%) levels, but only for the rats exposed to 137Cs intake in adulthood. Large changes in 17β-estradiol (–69%) and corticosterone (+36%) levels affected steroidogenesis, but only in the adult model. This study showed that response profiles differed according to age at exposure: lipid metabolism was most radiosensitive in the postnatal model, and steroid hormone metabolism was most radiosensitive in rats exposed in adulthood. There was no evidence of deleterious effects suggesting a potential impact on fertility or procreation.

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Section: Resultssupporting

confidence: 87%

Section: Resultsmentioning

confidence: 60%

Chronic exposure of adult, postnatal and in utero rat models to low-dose 137Cesium: impact on circulating biomarkers

Manens¹,

Grison²,

Bertho³

et al. 2016

Journal of Radiation Research

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“…The activity expressed in Bq/g of tissue in the skeletal muscle after 6 months exposure was 0.12 ± 0.09; 8.00 ± 0.11; 37.58 ± 0.20; 191.91 ± 0.50 for 0, 4, 20 and 100 kBq/l respectively, and after 9 months exposure was 0.08 ± 0.08; 10.02 ± 0.15; 46.49 ± 0.49; 278.41 ± 1.00 for 0, 4, 20 and 100 kBq/l respectively. The resulting absorbed radiation doses due to 137 Cs ingestion were calculated as previously described [46] and were 3, 15, and 75 mGy after 6 months and 6, 30, and 150 mGy after 9 months exposure to 4, 20 and 100 kBq/l of 137 Cs, respectively. Exposure to 137 Cs did not alter body weight in ApoE -/-mice at any time over the 9 months of treatment, compared with unexposed mice (Fig 2).…”

Section: Resultsmentioning

confidence: 99%

“…The detection limit ranged from 4.2 to 12 counts per minute per sample, depending on the mass of the organ tested and the duration of the counting period. The radiation dose received by the muscle was calculated according to models developed for rodents [45], as previously described [46].…”

Section: Cs 137 Measurementmentioning

confidence: 99%

Chronic internal exposure to low dose 137CS induces positive impact on the stability of atherosclerotic plaques by reducing inflammation in APOE-/- MICE

et al. 2015

Self Cite

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After Chernobyl and Fukushima Daï Chi, two major nuclear accidents, large amounts of radionuclides were released in the environment, mostly caesium 137 ( 137 Cs). Populations living in contaminated territories are chronically exposed to radionuclides by ingestion of contaminated food. However, questions still remain regarding the effects of low dose ionizing radiation exposure on the development and progression of cardiovascular diseases. We therefore investigated the effects of a chronic internal exposure to 137 Cs on atherosclerosis in predisposed ApoE -/-mice. Mice were exposed daily to 0, 4, 20 or 100 kBq/l 137 Cs in drinking water, corresponding to range of concentrations found in contaminated territories, for 6 or 9 months. We evaluated plaque size and phenotype, inflammatory profile, and oxidative stress status in different experimental groups. Results did not show any differences in atherosclerosis progression between mice exposed to 137 Cs and unexposed controls. However, 137 Cs exposed mice developed more stable plaques with decreased macrophage content, associated with reduced aortic expression of pro-inflammatory factors (CRP, TNFα, MCP-1, IFNγ) and adhesion molecules (ICAM-1, VCAM-1 and E-selectin). Lesions of mice exposed to 137 Cs were also characterized by enhanced collagen and smooth muscle cell content, concurrent with reduced matrix metalloproteinase MMP8 and MMP13 expression. These results suggest that low dose chronic exposure of 137 Cs in ApoE -/-mice enhances atherosclerotic lesion stability by inhibiting pro-inflammatory cytokine and MMP production, resulting in collagen-rich plaques with greater smooth muscle cell and less macrophage content.

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“…11,15,17,18,21,24,27,33,39,45,46,49,53,[78][79][80][81][82] These were largely adopted for calculation of organ absorbed dose and dosimetry of radionuclide-labeled compounds in preclinical experiments. [83][84][85][86][87][88][89][90][91][92][93][94][95] These computational models were also integrated in comparative Monte Carlo-based simulations studies investigating patterns of uptake and biodistribution data of radiopharmaceuticals for the purpose of dose estimation in molecular radiotherapy and diagnostic nuclear medical imaging procedures. [96][97][98][99][100][101][102][103][104][105][106][107] For external exposure to ionizing radiation, few studies reported on the calculation of organ dose conversion coefficients for small animals under ideal irradiation conditions (left lateral, right lateral, dorsal-ventral, ventral-dorsal, and isotropic irradiation directions), …”

Section: A Ionizing Radiation Dosimetrymentioning

confidence: 99%

Development of computational small animal models and their applications in preclinical imaging and therapy research

Xie

Zaidi

2015

Med. Phys.

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The development of multimodality preclinical imaging techniques and the rapid growth of realistic computer simulation tools have promoted the construction and application of computational laboratory animal models in preclinical research. Since the early 1990s, over 120 realistic computational animal models have been reported in the literature and used as surrogates to characterize the anatomy of actual animals for the simulation of preclinical studies involving the use of bioluminescence tomography, fluorescence molecular tomography, positron emission tomography, single-photon emission computed tomography, microcomputed tomography, magnetic resonance imaging, and optical imaging. Other applications include electromagnetic field simulation, ionizing and nonionizing radiation dosimetry, and the development and evaluation of new methodologies for multimodality image coregistration, segmentation, and reconstruction of small animal images. This paper provides a comprehensive review of the history and fundamental technologies used for the development of computational small animal models with a particular focus on their application in preclinical imaging as well as nonionizing and ionizing radiation dosimetry calculations. An overview of the overall process involved in the design of these models, including the fundamental elements used for the construction of different types of computational models, the identification of original anatomical data, the simulation tools used for solving various computational problems, and the applications of computational animal models in preclinical research. The authors also analyze the characteristics of categories of computational models (stylized, voxel-based, and boundary representation) and discuss the technical challenges faced at the present time as well as research needs in the future. C 2016 American Association of Physicists in Medicine. [http://dx

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Absorbed radiation doses due to chronic ingestion of cesium-137 or strontium-90 by mice

Abstract: The knowledge of the absorbed radiation dose is essential in order to

Cited by 11 publications

References 20 publications

Chronic exposure of adult, postnatal and in utero rat models to low-dose 137Cesium: impact on circulating biomarkers

Chronic exposure of adult, postnatal and in utero rat models to low-dose 137Cesium: impact on circulating biomarkers

Chronic internal exposure to low dose 137CS induces positive impact on the stability of atherosclerotic plaques by reducing inflammation in APOE-/- MICE

Development of computational small animal models and their applications in preclinical imaging and therapy research

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