Absorbent alginate fibres modified with hydrolysed chitosan for wound care dressings – II. Pilot scale development

Sweeney, I; Miraftab, Mohsen; Collyer, Graham J.

doi:10.1016/j.carbpol.2013.10.053

Cited by 64 publications

(25 citation statements)

References 21 publications

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“…The new chitosan wound dressing reported on in this study is an advanced wound dressing made from acylated chitosan fibre. Acylated chitosan is a chitosan derivative, which gels on absorbing wound fluid and is considered to be very suitable for the treatment of chronic wounds with a high exudates level as the study has demonstrated.…”

Section: Discussionmentioning

confidence: 99%

An open multicenter comparative randomized clinical study on chitosan

Mo¹,

Cen²,

Gibson

et al. 2015

Wound Repair Regeneration

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Chitosan, a natural polysaccharide derivate from chitin, offers a promising alternative biomaterial for use in wound dressings. In this work, the safety and efficacy of a next-generation KA01 chitosan wound dressing in facilitating the healing of nonhealing chronic wounds was studied. This open multicenter comparative prospective randomized clinical study was conducted at three medical centers in China. A total of 90 patients (45 in test group and 45 in control group) with unhealed chronic wounds including pressure ulcers, vascular ulcers, diabetic foot ulcers, and wounds with minor infections, or at risk of infection, were treated with the next generation chitosan wound dressing as the test article or traditional vaseline gauze as a control. Baseline assessments were undertaken with the primary end point being wound area reduction. The secondary end points included pain reduction (using the NRS11 pain scale) at dressing change, wound exudate levels, wound depth and duration of the treatment. After 4 weeks treatment, the wound area reduction was significantly greater in the test group (65.97 ± 4.48%) than the control group (39.95 ± 4.48%). The average pain level in the test group was 1.12 ± 0.23 and 2.30 ± 0.23 in the control group. The wound depth was also lower in the test group 0.30 ± 0.48 cm than the control group 0.54 ± 0.86 cm. The level of exudate fell and the dressing could be removed integrally in both the test and control groups. The mean duration of the test group was 27.31 ± 5.37 days and control group 27.09 ± 6.44 days. No adverse events were reported in either group. In conclusion this open multicenter comparative prospective randomized clinical study has provided compelling evidence that the next generation chitosan wound dressing can enhance wound progression towards healing by facilitating wound reepithelialization and reducing the patients pain level. Furthermore the dressing was shown to be clinically safe and effective in the management of chronic wounds.

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Section: Discussionmentioning

confidence: 99%

An open multicenter comparative randomized clinical study on chitosan

Mo¹,

Cen²,

Gibson

et al. 2015

Wound Repair Regeneration

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show abstract

“…In 1947, Blaine conducted an experimental observation of absorbable alginic acid surgical materials, and it was confirmed that alginic acid gel, film, gauze, and foam have stable absorbability and hemostatic effect . Since the amount of guluronic acid and mannuronic acid contained in the alginic acid molecule is different, the composition and relative molecular mass of alginic acid also exhibit diversity, so alginate and its mixture has a wide range of functional diversity, namely, good hygroscopicity, easy release, high oxygen permeability, gel blocking, biodegradability, compatibility, and metal ion adsorption . Alginic acid molecules are block linear polymers composed of β‐D‐1,4‐mannuronic acid and α‐L‐1,4‐guluronic acid.…”

Section: Hemostasis At Nanoscalementioning

confidence: 99%

Recent Advances in Hemostasis at the Nanoscale

Wang

Liu

Sui

et al. 2019

Adv Healthcare Materials

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Rapid and effective hemostatic materials have received wide attention not only in the battlefield but also in hospitals and clinics. Traditional hemostasis relies on materials with little designability which has many limitations. Nanohemostasis has been proposed since the use of peptides in hemostasis. Nanomaterials exhibit excellent adhesion, versatility, and designability compared to traditional materials, laying a good foundation for future hemostatic materials. This review first summarizes current hemostatic methods and materials, and then introduces several cutting‐edge designs and applications of nanohemostatic materials such as polypeptide assembly, electrospinning of cyanoacrylate, and nanochitosan. Particularly, their advantages and working mechanisms are introduced. Finally, the challenges and prospects of nanohemostasis are discussed.

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“…The massive interconnected pores improve the air permeability, solution absorption, and storage performance of the needle‐punched nonwovens . The porous structure, high porosity, and large specific area make needle‐punched nonwovens be used wildly as biomaterials such as tissue engineering scaffolds, bone tissue substitutes, and wound dressings …”

Section: Introductionmentioning

confidence: 99%

Characterizing the degradation behavior of calcium alginate fibers wound dressings fabricated by needle‐punching process

Gao

Jin

2018

J of Applied Polymer Sci

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Calcium alginate fibers (CAFs) needle‐punched nonwovens are natural polysaccharide biological dressings. Wound exudates cause salt degradation of CA macromolecules. Herein, degradation process, degradation mechanism, and performance variations of degraded dressings were investigated. The functional group structures changed slightly, while the aggregation structure degraded remarkably. CAF turned into composite containing fiber and sodium alginate (SA) gels, finally degraded to SA gels. The initial degraded dressings maintained stable three‐dimensional (3D) interconnected porous structure. As the degradation and re‐entanglement of CAFs, the dressings changed from volatile composite constituted by degraded CAFs and SA gels to steady foam‐like structure bonded by SA gels with independent pores. Degradation caused significant changes in the interaction between CAFs, altering the stretching and compressing processes of the dressings. SA gels and CAFs formed a stable 3D structure with certain mechanical properties. The bonded SA gels improved the absorption, diffusion, and storage of the wound exudates in the degraded dressings. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46670.

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Absorbent alginate fibres modified with hydrolysed chitosan for wound care dressings – II. Pilot scale development

Cited by 64 publications

References 21 publications

An open multicenter comparative randomized clinical study on chitosan

An open multicenter comparative randomized clinical study on chitosan

Recent Advances in Hemostasis at the Nanoscale

Characterizing the degradation behavior of calcium alginate fibers wound dressings fabricated by needle‐punching process

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