Absorption and Excretion of Calcium and Fat by Young Infants

Southgate, D. A. T.; Widdowson, E. M.; Smits, B. J.; Cooke, W. T.; Walker, Cheryl H.; Mathers, N.P.

doi:10.1016/s0140-6736(69)91589-x

Cited by 63 publications

(21 citation statements)

References 21 publications

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“…18,19 It is known that preterm infants in our environment are given various natural feeds and formulae, which may differ from one infant to another. The calcium and phosphorus content of such supplementary feeds may differ and, 20,21 which means that even when supplemented with other feeds preterm infants may develop metabolic bone disease. However, this needs to be evaluated by further studies in our environment.…”

Section: Discussionmentioning

confidence: 99%

A high prevalence of metabolic bone disease in exclusively breastfed very low birthweight infants in Dar-es-Salaam, Tanzania

Msomekela¹,

Manji²,

Mbise³

et al. 1999

Annals of Tropical Paediatrics

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Metabolic bone disease (MBD), or rickets, is common in very low birthweight infants. A descriptive, cross-sectional, hospital-based study was carried out at Muhimbili Medical Centre, Dar-es-Salaam from 15 April to 30 June, 1995 to discover the magnitude, contributory factors, morbidity and suitable biochemical diagnostic tests for MBD. One hundred infants with a postnatal age of 6-12 weeks, whose birthweights were 1500 g or less were studied. Thirty-three of 100 (33%) infants, 16 boys and 17 girls, were radiographically diagnosed as having metabolic bone disease. The mean (SD) gestational age of those infants was 30.4 (2.7) weeks, while that of the infants without metabolic bone disease was 32.4 (3) weeks (p = 0.003). There was no significant difference in birthweight, serum calcium and serum phosphate levels between those infants with MBD and those without. The mean (SD) serum alkaline phosphatase in infants with MBD was 1052.9 (493.3) U/l and 766.8 (301.7) in those without MBD (p = 0.006). Thus, metabolic bone disease is common in very low birthweight infants. Wrist radiography and serum alkaline phosphatase levels remain important diagnostic tools. MBD should be considered seriously in very low birthweight infants.

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Section: Discussionmentioning

confidence: 99%

A high prevalence of metabolic bone disease in exclusively breastfed very low birthweight infants in Dar-es-Salaam, Tanzania

Msomekela¹,

Manji²,

Mbise³

et al. 1999

Annals of Tropical Paediatrics

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“…Loss of calcium and of fat in the stools has been shown to be interrelated (7,14,32). Not only are high fat intakes associated with decreased calcium absorption rates from the gut, but also high calcium intakes may lead to reduced fat absorption.…”

Section: Discussionmentioning

confidence: 99%

Growth and Mineral Metabolism in Very Low Birth Weight Infants. II. Effects of Calcium Supplementation on Growth and Divalent Cations

et al. 1975

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“…However, vitamin E deficiency and haemolytic anaemia have been reported recently in premature infants receiving a modified cow's milk formula (not supplemented with vitamin E) (Lo, Frank, and Hitzig, 1973). Another probable consequence of bile salt deficiency is impaired absorption of calcium and magnesium due to the formation of insoluble soaps with fatty acids in the presence of steatorrhoea (Southgate et al, 1969;Bliss, Small, and Donaldson, 1972).…”

Section: Le IIImentioning

confidence: 99%

Role of bile salts in fat malabsorption of premature infants

Signer¹,

Murphy²,

Edkins³

et al. 1974

Archives of Disease in Childhood

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. Role of bile salts in fat malabsorption of premature infants. Eighteen premature infants were studied. 9 were fed with human milk and 9 with a modified cow's milk. Subsequent to a 72-hour fat balance, a duodenal intubation was performed on the 14th day of life. Total bile acids were determined in serial duodenal aspirates before and after a milk feed. Bile acid excretion in the faeces during a 72-hour period was also measured.Infants fed with human milk absorbed fat better (mean fat absorption coefficient, 75 %o) than those receiving a cow's milk formula (mean fat absorption coefficient, 60%). In both groups the bile acid concentrations after a meal were often less than that required for the formation of micellar solutions and solubilization of fat (i.e. <2 mmol/l.). With human milk, a reasonable fat absorption occurred even with bile acid levels below the critical micellar concentration. In the infants fed with the cow's milk formula, impaired fat absorption was correlated with low bile acid levels. Infants on human milk excreted less bile acids in the stool (mean, 41 -9 ,umol/kg per 24 hr) than did infants fed with the cow's milk formula (mean, 72 -4,mol/kg per 24 hr). In both groups the faecal loss of bile acids was increased compared with that in older infants and children.

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Absorption and Excretion of Calcium and Fat by Young Infants

Cited by 63 publications

References 21 publications

A high prevalence of metabolic bone disease in exclusively breastfed very low birthweight infants in Dar-es-Salaam, Tanzania

A high prevalence of metabolic bone disease in exclusively breastfed very low birthweight infants in Dar-es-Salaam, Tanzania

Growth and Mineral Metabolism in Very Low Birth Weight Infants. II. Effects of Calcium Supplementation on Growth and Divalent Cations

Role of bile salts in fat malabsorption of premature infants

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