Absorption and Fate of l- and d-Lactic Acid in Ruminants

Møller, Per; Diernæs, L; Sehested, Jakob; Hyldgaard‐Jensen, J.; Skadhauge, Erik

doi:10.1016/s0300-9629(96)00325-8

Cited by 16 publications

(9 citation statements)

References 3 publications

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“…example of a diet-related bacterial disorder related to lactic acid accumulation is acidosis in the rumen of dairy cows. Acidosis is caused by change to a diet containing a rapidly degradable substrate for lactic acid bacteria, leading to a rapid lactic acid accumulation and, as a consequence, inhibition and washout of most members of the natural microbial community of the rumen (8,33). Still, some lactic acid production is often considered beneficial in the GI tract because it inhibits the growth of several potential intestinal pathogens such as Salmonella, Clostridium, and Escherichia (17,22,23,35,40).…”

Section: Discussionmentioning

confidence: 99%

Culture-Independent Microbial Community Analysis Reveals that Inulin in the Diet Primarily Affects Previously Unknown Bacteria in the Mouse Cecum

Apajalahti¹,

Kettunen

Kettunen³

et al. 2002

Appl Environ Microbiol

117

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Inulin is a well-known fructose-based prebiotic which has been shown to stimulate the growth of bifidobacteria, a bacterial group generally considered beneficial for intestinal health. In the present study, we analyzed inulin-associated shifts in the total bacterial community of wild-type mice and mice carrying a genetically inactivated adenomatous polyposis coli tumor suppressor gene by using DNA-based approaches independent of bacterial culturability. Mice were fed a high-fat, nonfiber diet with or without inulin inclusion at a 10% (wt/wt) concentration. Cecal contents were analyzed after 0, 3, and 9 weeks on the experimental diets. Inulin inclusion significantly affected the total bacterial community structure of the cecum as determined by both a nonselective percent-guanine-plus-cytosine-based profiling analysis and a more specific 16S ribosomal DNA sequence analysis. The shifts included stimulation of bifidobacteria and suppression of clostridia, but sequence comparison revealed that the major shifts were within previously unknown bacterial taxa. Concomitantly, significantly higher bacterial densities, determined by flow cytometry, were observed with the inulin-amended diet, and the metabolism of the cecal bacterial community was altered, as indicated by higher levels of residual short-chain fatty acids, particularly lactic acid. With regard to all of the microbiological parameters measured, the wild-type mice and mice carrying a genetically inactivated adenomatous polyposis coli tumor suppressor gene were essentially identical. Studies of the implications of pre-and probiotics may need to be expanded to include careful analysis of their effects on the entire microbial community, rather than just a few well-known species. Further studies are needed to increase our understanding of the possible roles of currently unknown gastrointestinal bacteria in health and disease.

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Section: Discussionmentioning

confidence: 99%

Culture-Independent Microbial Community Analysis Reveals that Inulin in the Diet Primarily Affects Previously Unknown Bacteria in the Mouse Cecum

Apajalahti¹,

Kettunen

Kettunen³

et al. 2002

Appl Environ Microbiol

117

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“…In animals, it has been reported in ruminants secondary to grain overload (Moller et al. , Owens et al. ), in calves with diarrhoea (Omole et al.…”

Section: Introductionmentioning

confidence: 99%

“…d-lactic acidosis occurs in humans with short-bowel syndrome (Uribarri et al 1998, Ewaschuk et al 2005. In animals, it has been reported in ruminants secondary to grain overload (Moller et al 1997, Owens et al 1998, in calves with diarrhoea (Omole et al 2001, Ewaschuk et al 2004 and in a single cat suffering from exocrine pancreatic insufficiency with intestinal bacterial overgrowth (Cohn et al 2005). d-lactate concentration increases significantly secondary to infection, trauma and damage to the digestive barrier by ischaemia and necrosis (Smith et al 1989, Sun et al 2001.…”

Section: Introductionmentioning

confidence: 99%

Blood concentrations ofd‐ andl‐lactate in healthy rabbits

Langlois

Planché

Boysen

et al. 2014

J of Small Animal Practice

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“…6 Because D-lactate is metabolized by mammals at approximately one fifth the rate of L-lactate, it accumulates in the blood. 7 Similar pathogeneses of D-lactic acidosis result from grain overfeeding of ruminants 8 and in short-bowel syndrome in humans. 9 The accumulation of milk in the reticulorumen of calves with abomasal volvulus 10 esophageal groove reflex disorders, reduced forestomach motility, or abomasoruminal reflux also result in high AG metabolic acidosis.…”

mentioning

confidence: 98%

Anion Gap Correlates with Serum D‐ and DL‐Lactate Concentration in Diarrheic Neonatal Calves

Ewaschuk

Naylor

Zello

2003

Veterinary Internal Medicne

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The objective of this study was to investigate the relationship between serum D- and L-lactate concentrations, and anion gap (AG) in neonatal calves. The association of AG with lactic acidosis in diarrheic calves has only been investigated by measurement of L-lactate in calves with experimentally induced diarrhea. D-lactate has recently been reported to be present in high concentrations in the serum of some diarrheic neonatal calves. The contribution of this acid to AG is not reported. The relationship between AG and L- and D-lactate concentrations was examined in 24 healthy calves and 52 calves with naturally occurring infectious diarrhea with metabolic acidosis. AG was calculated as [Na+ + K+] - [Cl- + HCO3-]. D- and L-lactate were quantified using high-performance liquid chromatography. There was no correlation between L-lactate and AG, contrary to previous reports in the literature. Moderate correlations between D-lactate concentration and AG (r = .74, P < .0001), and between DL-lactate and AG (r = .77), P < .0001) were detected. No differences existed due to the age or sex of the calf. This study indicates that AG provides information on the nature of acidosis in the diarrheic, neonatal calf and reinforces the importance of investigating clinical, in addition to experimental, populations.

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Absorption and Fate of l- and d-Lactic Acid in Ruminants

Cited by 16 publications

References 3 publications

Culture-Independent Microbial Community Analysis Reveals that Inulin in the Diet Primarily Affects Previously Unknown Bacteria in the Mouse Cecum

Culture-Independent Microbial Community Analysis Reveals that Inulin in the Diet Primarily Affects Previously Unknown Bacteria in the Mouse Cecum

Blood concentrations ofd‐ andl‐lactate in healthy rabbits

Anion Gap Correlates with Serum D‐ and DL‐Lactate Concentration in Diarrheic Neonatal Calves

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