Absorption as a Factor in Manganese Homeostasis

Abrams, Elizabeth T.; Jw, Lassiter; Wj, Miller; Mw, Neathery; Rp, Gentry; Rd, Scarth

doi:10.2527/jas1976.423630x

Cited by 26 publications

(10 citation statements)

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“…Rather, the very small amounts of S4Mn secreted following duodenal dosing on either diet show quite clearly that the level of dietary Mn had no great effect on biliary excretion of duodenally administered S4Mn. These data are consistent with the concept developed from data of Abrams et al (1976), that change in the percentage absorbed is a major route of homeostatic control for manganese.…”

Section: Discussionsupporting

confidence: 90%

“…Endogenous excretion of Mn is very sensitive to level of dietary Mn (Cotzias and Greenough, 1958;Bertinchamps et al, 1966;Watson et al, 1973). However, differences in endogenous excretion alone cannot account for all the effects observed on tissue S4Mn of animals fed various concentrations of dietary Mn (Howes and Dyer, 1971;Carter et al, 1974;Abrams et al, 1976).…”

Section: Introductionmentioning

confidence: 99%

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Effect of Normal and High Manganese Diets on the Role of Bile in Manganese Metabolism of Calves

Abrams

et al. 1977

Journal of Animal Science

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The role of bile in manganese metabolism and homeostasis was studied in Holstein bull calves fed diets containing 32 ppm manganese (normal) (control) or 1,000 ppm supplemental manganese (high-manganese) for 2 weeks before and 1 week after intravenous (IV) and duodenal S4Mn dosing. After dosing, all the bile was collected at 15 and 60 minutes, hourly to 12 hr and daily to 7 days. All calves were sacrificed 7 days after dosing to determine the tissue S4Mn distribution. High-Mn-fed calves secreted 48% of the IV S4Mn dose in bile over the 7-day period; which was 12 times that in bile of control calves. In contrast, after duodenal dosing, only a very small amount of S4Mn was secreted in bile by either control (.32%) or high-Mn-fed (.30%) calves over the 7-day period. With both methods of dosing, calves fed the high-Mn diets had a lower average S4Mn concentration in most tissues taken than calves fed the control diet. These data from IV dosing confirm earlier work that excretion and tissue distribution of injected S4Mn is very sensitive to dietary Mn. The data from duodenally-dosed calves showed that the amount of Mn absorbed is decreased by higher dietary Mn intake. In contrast to previously held theory, enterohepatic circulation of Mn apparently plays only a minor role in homeostasis of fed Mn. Manganese homeostasis in calves appears to be the result of changes both of absorption and

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Effect of Normal and High Manganese Diets on the Role of Bile in Manganese Metabolism of Calves

Abrams

et al. 1977

Journal of Animal Science

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“…Homeostasis of Mn tissue content is controlled by uptake, distribution and elimination mechanisms (Abrams et al. ). To decrease intracellular concentration, Mn is transported across the plasma membrane by ferroportin transporter (Yin et al.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, genome instability and endomitosis can be triggered by alterations in cytosolic or Golgi Mn2 + levels (García-Rodríguez et al 2012). Homeostasis of Mn tissue content is controlled by uptake, distribution and elimination mechanisms (Abrams et al 1976). To decrease intracellular concentration, Mn is transported across the plasma membrane by ferroportin transporter (Yin et al 2010), whereas ZIP family (He et al 2006;Himeno et al 2009), divalent metal transporter 1 (DMT1) and transferrin receptor are mechanisms for increasing intracellular Mn level (Gunshin et al 1997;Garrick et al 2003).…”

Section: Introductionmentioning

confidence: 99%

Effect of Different Manganese Concentrations during in vitro Maturation of Bovine Oocytes on DNA Integrity of Cumulus Cells and Subsequent Embryo Development

Anchordoquy

Sirini

Mattioli

et al. 2013

Reprod Domestic Animals

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Manganese (Mn) is a trace element present in forages and cereals, and its concentration depends on soil status. Manganese deficiency in cattle, goats and ewes not only impairs oestrous cycle but reduces calf birth weight. The achievement of the first oestrus is delayed, and more attempts are necessary to obtain a successful conception. This study was conducted to investigate the effect of the availability of supplemental Mn during IVM on DNA damage of cumulus cells and total glutathione (GSH) content in oocytes and cumulus cells. The effect of supplementary Mn during IVM on subsequent embryo development was also studied. The results reported here indicate (i) DNA damage in cumulus cells decreased with 0, 2, 5 and 6 ng/ml Mn supplementation during IVM (p < 0.05). (ii) Intracellular GSH-GSSG content increased (p < 0.01) with different Mn concentrations in oocytes and cumulus cells. Also, cumulus cell number per cumulus oocyte-complexes (COC) did not differ either before or after IVM. (iii) Addition of Mn to maturation medium resulted in similar cleavage rates (p > 0.05) at 0, 2, 5 and 6 ng/ml Mn. However, subsequent embryo development to blastocyst stage was significantly higher (p < 0.01) in oocytes matured with 5 and 6 ng/ml Mn. (iv) There was also an increase (p < 0.05) in mean cell number per blastocyst obtained from oocytes matured with 5 and 6 ng/ml respect to zero Mn (IVM alone) and 2 ng/ml Mn. This study provides evidence that optimal embryo development to the blastocyst stage was partially dependent on the presence of Mn during IVM. Moreover, the availability of Mn during oocyte maturation ensures 'normal' intracellular GSH content in COCs and protects DNA integrity of cumulus cells.

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“…When dietary Mn levels are high, adaptive changes include reduced gastrointestinal (GI) absorption of Mn, enhanced Mn liver metabolism, and increased biliary and pancreatic excretion of Mn (Aschner and Aschner, 2005). For example, when rats were given an oral tracer dose of MnCl 2 , the amounts found in the stomach, duodenum, and jejunum on a % dose/g tissue basis decreased as dietary Mn increased from 4 to 2000 ppm (Abrams et al, 1976). Some studies suggest that Mn is absorbed through an active transport mechanism (Garcia-Aranda, Wapnir and Lifshitz, 1983), which most likely involves the metal divalent transporter 1, referred as DMT1 (also known as DCT-1 or nramp-2) (Bai et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Manganese in human parenteral nutrition: Considerations for toxicity and biomonitoring

et al. 2014

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The iatrogenic risks associated with excessive Mn administration in parenteral nutrition (PN) patients are well documented. Hypermanganesemia and neurotoxicity are associated with the duration of Mn supplementation, Mn dosage, as well as pathological conditions, such as anemia or cholestasis. Recent PN guidelines recommend the biomonitoring of patients if they receive Mn in their PN longer than 30 days. The data in the literature are conflicting about the method for assessing Mn stores in humans as a definitive biomarker of Mn exposure or induced-neurotoxicity has yet to be identified. The biomonitoring of Mn relies on the analysis of whole blood Mn (WB Mn) levels, which are highly variable among human population and are not strictly correlated with Mn-induced neurotoxicity. Alterations in dopaminergic (DAergic) and catecholaminergic metabolism have been studied as predictive biomarkers of Mn-induced neurotoxicity. Given these limitations, this review addresses various approaches for biomonitoring Mn exposure and neurotoxic risk.

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Absorption as a Factor in Manganese Homeostasis

Cited by 26 publications

References 0 publications

Effect of Normal and High Manganese Diets on the Role of Bile in Manganese Metabolism of Calves

Effect of Normal and High Manganese Diets on the Role of Bile in Manganese Metabolism of Calves

Effect of Different Manganese Concentrations during in vitro Maturation of Bovine Oocytes on DNA Integrity of Cumulus Cells and Subsequent Embryo Development

Manganese in human parenteral nutrition: Considerations for toxicity and biomonitoring

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