Absorption, Distribution and Elimination Behaviours of Cadmium Treated by in vitro DIN from WLP Residue using SAAM II Modeling

Perama, Yasmin Mohd Idris; Rashid, Nur Shahidah Abdul; Fadzil, Syazwani Mohd; Khoo, Kok Siong

doi:10.17576/jsm-2018-4703-23

Cited by 3 publications

(8 citation statements)

References 10 publications

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“…The simulation by the present model of concentration of cadmium in the small intestine compares favorably with the experiment of Perama and co-researchers [14]. In the experiment conducted by Perama and cohorts, using synthetic gastrointestinal fluids, the concentration of cadmium in gastrointestinal fluids were simulated and measured [14].…”

Section: Discussionsupporting

confidence: 60%

“…The result of simulations by the present model are compared with some experimental observations found in literature and presented in Figure 2 to Figure 4 and in Table 4. While Figure 2 compares the experiment conducted by [14] with the simulation by the present model. Figure 3 is a comparison of a Swedish autopsy studies [17] and the current model simulation.…”

Section: Resultsmentioning

confidence: 99%

“…Materials used in this study were Python software environment, Graph data extractor. Experimental observations used in evaluating the model were mainly from the work of [14][15][16][17]. Where these empirical observations and simulations were presented in graphical form, they were extracted using a software, Graph data extractor.…”

Section: Methodsmentioning

confidence: 99%

“…To evaluate the performance of the current model, the results of some experimental observations and other simulations found in literature were simulated. Results of researches conducted by a host of other researchers [14,15,17] and a simulation by [16] were simulated using the model developed in this study.…”

Section: Simulationsmentioning

confidence: 99%

“…In a study conducted by Perama and collaborators using synthetic gastrointestinal fluids, the concentration of cadmium in gastrointestinal fluids were simulated and measured [14]. It was a short term simulation using a bolus dose of 0.75 mg/kg.…”

Section: Simulationsmentioning

confidence: 99%

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A Human Physiologically-based Bio-kinetic Model for Cadmium

Maza¹,

Olukotun²,

Akinlade³

2021

AJMCM

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A physiologically-based bio-kinetic (PBBK) model, capable of simulating the absorption, distribution, and elimination of cadmium in humans has been developed. The formulation of this model was based on human data cleaned from literature. The liver, kidney, lung, artery, vein, stomach, small intestine and remainder of the body (other tissues not modelled explicitly) were modelled as compartments. While transfer rate coefficients were used to describe the kinetics of cadmium in the gastrointestinal track, the model used blood flow rates and partition coefficients rather than the traditional transfer rate coefficients to describe the distribution and accumulation of the chemical into critical organs such as liver, kidney and remainder of the body. A perfusion rate-limited kinetics model was assumed for these critical organs, where each of these tissues was regarded as a well-stirred compartment, without any concentration gradient within the compartment. The partition coefficients for critical organs modelled, along with transfer rate coefficients describing oral ingestion and inhalation were estimated by fitting the simulated concentration of cadmium in the liver, kidney and urine to observed concentrations found in literature. The model was capable of simulating, to a good degree of success, the results of empirical observations and other simulations found in literature. Simulations by the model also indicate that the partition coefficient of cadmium for the kidney, liver and other critical organs was higher in smokers.

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Section: Discussionsupporting

confidence: 60%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Simulationsmentioning

confidence: 99%

Section: Simulationsmentioning

confidence: 99%

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A Human Physiologically-based Bio-kinetic Model for Cadmium

Maza¹,

Olukotun²,

Akinlade³

2021

AJMCM

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Mechanism of cadmium-induced nephrotoxicity

Bautista,

Arango,

Plata

et al. 2024

Toxicology

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The Toxicity of Environmental Pollutants

Ismaël¹,

Sorho²

2022

The Toxicity of Environmental Pollutants

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In view of the growing threat of trace metals to human health, this work set itself the objective of documenting the toxicity of the trace metals most in contact with humans on human health through food. Thus, this study revealed that organic matter, pH and CEC are the main soil parameters that influence the passage of trace metals from soil to plants. The study also revealed that agriculture, industry and road traffic contribute greatly to the input of trace metals into the environment. Regarding the mechanisms of toxicity, the study showed that chromium VI and copper manifested their toxicity by the formation of free radicals after reduction, those of zinc, nickel, manganese and nickel resulting from the disfunctioning of homeostasis. The study showed that lead caused toxic effects by replacing certain cations such as Ca2+, Mg2+, Fe2+, Na+ which have important functions in the cell. Cadmium expresses its toxicity by binding to albumin, thus altering the homeostasis of metals such as calcium. All these mechanisms have revealed both acute and chronic toxic effects.

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Absorption, Distribution and Elimination Behaviours of Cadmium Treated by in vitro DIN from WLP Residue using SAAM II Modeling

Cited by 3 publications

References 10 publications

A Human Physiologically-based Bio-kinetic Model for Cadmium

A Human Physiologically-based Bio-kinetic Model for Cadmium

Mechanism of cadmium-induced nephrotoxicity

The Toxicity of Environmental Pollutants

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