Absorption, distribution and elimination of fumonisin B<sub>1</sub>metabolites in weaned piglets

Fodor, József; Balogh, Krisztián; Kovács-Weber, Mária; Mézes, Miklós; Kametler, László; Pósa, Roland; Mamet, Rene; Bauer, Johann; Horn, Peter A.; Kovács, Ferenc; Kovács, Melinda

doi:10.1080/02652030701546180

Cited by 70 publications

(75 citation statements)

References 24 publications

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“…In monogastric animals (piglets), the accumulative absorption of FB 1 is only ca. 4% (15). However, as a result of coecotrophy in rabbit, the accumulative absorption may increase, while the hidden proportion, occurring in a matrix associated form may be liberated as well by the digestive enzymes (during the multiplied uptake via coecotrophy), leading ultimately to a higher toxin exposure than determined analytically from the food (34).…”

Section: Liver Mitochondrial Phospholipidsmentioning

confidence: 97%

“…Production of toxins and determination of mycotoxin content in fungal cultures and feeds FB 1 and T-2 toxin were produced with the application of Fusarium verticillioides strain MRC 826 and Fusarium sporotrichioides strain NRRL 3299, respectively (15). The homogenized fungal cultures contained FB 1 at a concentration of 3,440 mg/kg, while T-2 toxin concentration was 1,338 mg/kg (HT-2 toxin 285 mg/kg), respectively.…”

Section: Experimental Designmentioning

confidence: 99%

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Oral administration of fumonisin B₁and T-2 individually and in combination affects hepatic total and mitochondrial membrane lipid profile of rabbits

Szabó¹,

Szabó-Fodor²,

Fébel³

et al. 2016

Physiology International

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Weaned rabbits were fed diets contaminated with 2 mg/kg diet T-2 toxin alone, or 10 mg/kg diet fumonisin B 1 (FB 1 ) alone, and both toxins in combination (2 + 10 mg/kg, respectively) compared to a toxin-free control diet. Samplings were performed after 4 weeks (blood and liver). Bodyweight of T-2-fed group was lower after 4 weeks; the liver weight was increased dramatically (threefold of control). Liver total phospholipids (PLs) provided slight alterations in the fatty acid (FA) composition; all three toxin-treated groups showed a decrease in palmitoleic acid (C16:1 n7) proportion. In the liver mitochondrial PL FA composition, margaric acid (C17:0) proportion decreased in the separated toxin treatments compared to the combined setting. Oleic acid (C18:1 n9) proportion was increased and arachidonic acid (C20:4 n6) was decreased in the FB 1 -treated group, while docosapentaenoic acid (C22:5 n3) was decreased in the separated treatments. The total monounsaturation was significantly higher in the FB 1 group's mitochondrial PL FA profile. After 4 weeks, all toxin treatments decreased the blood plasma reduced glutathione and glutathione peroxidase activity, and FB 1 increased the plasma sphinganine/sphingosine ratio. Both mycotoxins seem to cross the hepatocellular and the hepatic mitochondrial membrane, without drastic membrane disruption, as assessed from the PL FA composition, but inducing detectable lipid peroxidation.

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Section: Liver Mitochondrial Phospholipidsmentioning

confidence: 97%

Section: Experimental Designmentioning

confidence: 99%

Oral administration of fumonisin B₁and T-2 individually and in combination affects hepatic total and mitochondrial membrane lipid profile of rabbits

Szabó¹,

Szabó-Fodor²,

Fébel³

et al. 2016

Physiology International

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“…Fumonisin B 1 was produced by the application of Fusarium verticillioides strain MRC 826 according to the method of Fodor et al (2008). The homogenised fungal culture contained FB 1 at a concentration of 3.44 g/kg.…”

Section: Mycotoxin Productionmentioning

confidence: 99%

Acute hepatic effects of low-dose fumonisin B1 in rats

Szabó

Szabó-Fodor

Fébel

et al. 2016

Acta Veterinaria Hungarica

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Adult male Wistar rats were enrolled in a study to test the acute hepatic effects of 50 mg/kg fumonisin B 1 in feed for 5 days. Fumonisin B 1 depressed growth and feed intake, and absolute and relative liver weight showed a significant increase. The proportions of C17:0, C18:3 n3, C22:5 n3 and C22:6 n3 fatty acids decreased in the hepatic phospholipid fraction. All proportional decreases modified the hepatocellular membrane lipids into a more rigid state. The fatty acid profile modifications were partly compensated for by endogenous glutathione (preventing the formation of conjugated dienes and trienes as initial phase lipid peroxidation indicators), while the enzymatic antioxidant defence system (glutathione peroxidase) was unaltered. In contrast, hepatic malondialdehyde, the cytotoxic product of end-phase lipid peroxidation showed a concentration increase even after 5 days of feeding. The results indicate a rather strong and rapid hepatic effect of FB 1 , immediately impairing membrane phospholipids, even before the enzymatic antioxidant defence is activated.Key words: Fumonisin B 1 , rat, hepatocellular membrane, fatty acids, oxidative stress, antioxidants Fumonisins are cancer-inducing metabolites of Fusarium proliferatum and Fusarium verticillioides. They have a long-chain hydrocarbon unit (mimicking to a certain extent cellular sphingosine and sphinganine), which plays a determinant role in their cell-membrane-associated toxicity. From the fumonisin group, fumonisin B 1 (FB 1 ) shows strong toxic effects and has been reported to promote hepatic tumour in rats. Fumonisin B 1 , the most abundant of the numerous fumonisin analogues, was classified by the IARC as a Group 2B carcinogen (possibly carcinogenic in humans; IARC, 2002).

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“…FB1 is metabolized into partially hydrolyzed FB1 and then to the hydrolyzed form (HFB1) in both gastrointestinal tract and liver, where it persists at low concentration for few more days in pigs [37]. FB1 was found to be more toxic than HFB1 in piglets [38].…”

Section: Fumonisinsmentioning

confidence: 99%

Mycotoxins in Poultry

Filazı¹,

Yurdakök-Dikmen²,

Kuzukiran³

et al. 2017

Poultry Science

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Mycotoxins, the toxic secondary metabolites of fungi, particularly produced by many species of Aspergillus, Fusarium and Penicillium, have afected animal and human health for over thousand years, whereas litle has been discovered so far about these complex substances in poultry, which are generally very sensitive. Even though it varies by species and sex, some common efects are reduced feed intake, weight gain, feed eiciency, growth performance, immunity and hatchability along with increased mortality, organ damages (mainly kidney and liver), carcinogenicity, teratogenicity and decreased egg production. Besides their adverse health efects and the decrease in production rate, concerns over their importance in public health is still under debate. Decontamination approaches to reduce mycotoxins in feed are technologically diverse and based on chemical, biological and physical strategies. Chemical remediation strategies involve the conversion of mycotoxins via chemical reactions. Biological strategies involve various substances such as plant ingredients, enzymes and microorganisms. Physical processes include sorting, milling, dehulling, cleaning, heating, irradiation or combinational approaches. New strategies for the prevention and treatment of mycotoxicosis, including beneicial microorganisms/products, along with alternative treatments, including plant extracts/essential oils, are current hot topics in the poultry industry.

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Absorption, distribution and elimination of fumonisin B₁metabolites in weaned piglets

Cited by 70 publications

References 24 publications

Oral administration of fumonisin B₁and T-2 individually and in combination affects hepatic total and mitochondrial membrane lipid profile of rabbits

Oral administration of fumonisin B₁and T-2 individually and in combination affects hepatic total and mitochondrial membrane lipid profile of rabbits

Acute hepatic effects of low-dose fumonisin B1 in rats

Mycotoxins in Poultry

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Absorption, distribution and elimination of fumonisin B1metabolites in weaned piglets

Cited by 70 publications

References 24 publications

Oral administration of fumonisin B1and T-2 individually and in combination affects hepatic total and mitochondrial membrane lipid profile of rabbits

Oral administration of fumonisin B1and T-2 individually and in combination affects hepatic total and mitochondrial membrane lipid profile of rabbits

Acute hepatic effects of low-dose fumonisin B1 in rats

Mycotoxins in Poultry

Contact Info

Product

Resources

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Absorption, distribution and elimination of fumonisin B₁metabolites in weaned piglets

Oral administration of fumonisin B₁and T-2 individually and in combination affects hepatic total and mitochondrial membrane lipid profile of rabbits

Oral administration of fumonisin B₁and T-2 individually and in combination affects hepatic total and mitochondrial membrane lipid profile of rabbits