Absorption, Distribution and Elimination of Cefazolin in Patients with Normal Renal Function

Bergan, Tom; Digranes, Asbjørn; Schreiner, A.

doi:10.1159/000237793

Cited by 9 publications

(1 citation statement)

References 6 publications

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“…However, the elderly patients had reduced renal function (mean creatinine clearance of approximately 50 mL/min), which most likely explains these findings. Studies on cefazolin and cephradine in a limited number of elderly subjects indicated prolonged serum half‐lives for both antibiotics, but renal function status of the patients were not reported 85 , 86 . Of the three oral preparations of first‐generation cephalosporins, i.e., cephalexin, cephradine, and cefadroxil, the latter agent has the advantage of increased serum half‐life and thus requiring dosing only every 12 hours 87 .…”

Section: Pharmacology and Pharmacokinetics Of Antibioticsmentioning

confidence: 99%

Antimicrobial Therapy for the Elderly Patient

Yoshikawa¹

1990

J American Geriatrics Society

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Section: Pharmacology and Pharmacokinetics Of Antibioticsmentioning

confidence: 99%

Antimicrobial Therapy for the Elderly Patient

Yoshikawa¹

1990

J American Geriatrics Society

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Pharmacokinetics of Cephradine Administered Intravenously and Orally to Young and Elderly Subjects

Schwinghammer

Norden

Gill

1990

The Journal of Clinical Pharma

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The pharmacokinetics of IV and oral cephradine in healthy young male and female volunteers (ages 19 to 25, n = 10) were compared to those of older individuals (ages 65 to 81, n = 9). Subjects received 1 gram of cephradine by a 5-minute intravenous (IV) infusion followed the next day by a 1-gram oral dose. Serial serum and urine samples collected over a period of 12 hours after the dose were analyzed for cephradine concentration by a microbiologic assay. After IV administration, mean serum cephradine concentrations in the elderly group were significantly higher at both 6 hours (1.52 +/- 0.41 mcg/mL) and 8 hours (0.73 +/- 0.22 mcg/mL) than in the young group at 6 hours (0.43 +/- 0.11 mcg/mL). Total systemic clearance was significantly lower (2.64 +/- 0.34 vs. 4.81 +/- 0.59 ml/min/kg) and the elimination half-life was significantly longer (1.71 +/- 0.20 vs 1.12 +/- 0.13 hours) in the elderly group (P = .0001). Systemic cephradine clearance correlated positively with creatinine clearance (r2 = 0.34, P = .0110) and negatively with age (r2 = 0.79, P = .0052). The mean volume of distribution was not significantly different between the two groups. Mean renal clearance was significantly lower in the elderly group (P = .0001), but more than 80% of the dose was excreted in the urine within 6 hours in both groups. After oral administration, the mean peak concentration and time to peak concentration did not differ between groups. The relative oral bioavailability was approximately 94% in both groups. The mean serum concentrations in the elderly were higher at both 6 and 8 hours than in the young group at 6 hours. There were no differences in pharmacokinetic parameters between male and female subjects. Because of reduced cephradine clearance secondary to an age-related decline in renal function, administration of cephradine every 8 hours, rather than every 6 hours, may be sufficient in elderly patients.

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Pharmacokinetics of β-Lactam Antibiotics

Kwan¹

1983

Antibiotics

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Absorption, Distribution and Elimination of Cefazolin in Patients with Normal Renal Function

Cited by 9 publications

References 6 publications

Antimicrobial Therapy for the Elderly Patient

Antimicrobial Therapy for the Elderly Patient

Pharmacokinetics of Cephradine Administered Intravenously and Orally to Young and Elderly Subjects

Pharmacokinetics of β-Lactam Antibiotics

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