Absorption, distribution and excretion of luteoskyrin with special reference to the selective action on the liver

Uraguchi, Kenji; Ueno, Ikuko; Ueno, Yoshio; Komai, Yoshitomo

doi:10.1016/0041-008x(72)90153-6

Cited by 15 publications

(1 citation statement)

References 10 publications

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“…Pharmacokinetic studies with 3H-luteoskyrin (5) showed that the hepatotoxicity in mice is ascribable to the selective concentration of the mycotoxin in the liver. Biochemi cal investigations revealed further that luteoskyrin acts as an inhibitor of the respiratory enzyme system (6) and the coupled phosphorylation (7) of liver mitochondria, and binds to DNA (8)(9)(10) with resultant suppression of RNA synthesis (I1).…”

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Pharmacokinetic Studies on the Hepatotoxicity of Luteoskyrin. (1) Intracellular Distribution of Radioactivity in the Liver of Mice Administered 3H-Luteoskyrin

Ueno

Hayashi

Ueno

1974

Japanese Journal of Pharmacology

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Luteoskyrin, one of the anthraquinoid metabolites of Pcnicilliunr is/uitdicunr Sopp, affects selectively the livers of mice and rats and causes both acute and chronic disorders including centrolobular necrosis, fatty metamorphosis, cirrhosis and hepatoma depending upon the dose and duration of administration (1-3).In order to elucidate the processes of development of the acute injury into a chronic intoxication, the authors performed toxicological studies of the acute stage of luteoskyrin intoxication, and found that this mycotoxin exhibits varying degrees of toxicity depending on the species, strain, sex and age of experimental animals; the susceptibility of nice is higher than that of rats, and in mice it is higher in males and infants than in females and adults (4).Pharmacokinetic studies with 3H-luteoskyrin (5) showed that the hepatotoxicity in mice is ascribable to the selective concentration of the mycotoxin in the liver. Biochemi cal investigations revealed further that luteoskyrin acts as an inhibitor of the respiratory enzyme system (6) and the coupled phosphorylation (7) of liver mitochondria, and binds to DNA (8-10) with resultant suppression of RNA synthesis (I1).In an attempt to confirm the possibility that luteoskyrin or its metabolites directly attack the cellular components of the liver to cause the above mentioned biochemical al terations in the course of the intoxication, intracellular distribution of the radioactivity derived from 3H-luteoskyrin in the liver of mice of different ages and sexes was examined. It was found that the large portion of the tritium label taken up by the liver was distribut

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confidence: 99%

Pharmacokinetic Studies on the Hepatotoxicity of Luteoskyrin. (1) Intracellular Distribution of Radioactivity in the Liver of Mice Administered 3H-Luteoskyrin

Ueno

Hayashi

Ueno

1974

Japanese Journal of Pharmacology

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Gastroenterologic Response to Environmental Agents — Absorption and Interactions

Pfeiffer

1977

Comprehensive Physiology

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The sections in this article are: General Principles of Interaction Between Environmental Agents and the Gut Mucosa Morphological Considerations General and Selected Physicochemical Principles Enteric Absorption and Mucosal Effects of Trace Elements Lead Nickel and Tin Mercury‐Containing Compounds Zinc and Cadmium Copper and Molybdenum Selenium Fluorine and Other Halogens Miscellaneous Trace Elements Mucosal Effects of Chemicals and Corrosives Gastrointestinal Absorption of Pesticides Absorption and Enteric Surface Effects of Miscellaneous Industrial Agents Polychlorinated Biphenyls and Triphenyls Polyglycerol Esters Organic Sulfonates and Other Surface‐Active Agents Dimethylsulfoxide Polyvinylchloride Stabilizers and Plasticizers Absorption and Enteric Surface Effects of Natural Environmental Contaminants Tannic Acid Miscellaneous Natural Compounds Ingestion of Carcinogenic Agents

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Metabolism of Chemical Carcinogens

Weisburger

Williams

1975

Cancer. A Comprehensive Treatise

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Absorption, distribution and excretion of luteoskyrin with special reference to the selective action on the liver

Cited by 15 publications

References 10 publications

Pharmacokinetic Studies on the Hepatotoxicity of Luteoskyrin. (1) Intracellular Distribution of Radioactivity in the Liver of Mice Administered 3H-Luteoskyrin

Pharmacokinetic Studies on the Hepatotoxicity of Luteoskyrin. (1) Intracellular Distribution of Radioactivity in the Liver of Mice Administered 3H-Luteoskyrin

Gastroenterologic Response to Environmental Agents — Absorption and Interactions

Metabolism of Chemical Carcinogens

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