Absorption of Cadmium

Foulkes, E. C.

doi:10.1007/978-3-642-70856-5_3

Cited by 40 publications

(30 citation statements)

References 78 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Transport of metals in cells can be visualized as a two-step process that involves binding to anionic sites on membrane phospholipids and proteins, including the plasma membrane receptors, and internalization (1). The metals may enter the cell by simple diffusion through nonspecific ion pores or through specific ion-channels like those for Ca++, Na+, and K+.…”

Section: Introductionmentioning

confidence: 99%

Metal transport in cells: cadmium uptake by rat hepatocytes and renal cortical epithelial cells.

Shaikh

Blazka

Endo

1995

Environ Health Perspect

View full text Add to dashboard Cite

The toxic metals appear to use the transport pathways that exist for biologically essential metals. In this regard interactions between the toxic and essential metals are possible. This report summarizes recent findings on the transport of cadmium in rat hepatocytes and renal cortical epithelial cells in the presence or absence of certain essential metals. The transport of cadmium in hepatocytes does not require energy and, therefore, is not an active process. It occurs primarily (80%) by temperature-sensitive processes, i.e., ion channels and carriers, that involve interaction with sulfhydryl groups. These processes apparently exist for the transport of essential metals like copper, zinc and calcium. The remaining 20% of the cadmium in hepatocytes is transported via a temperature-insensitive process, possibly by diffusion. In comparison with the hepatocytes, a smaller fraction (30%) of the cadmium transport through the basolateral membrane and none from the apical membrane of the renal cortical epithelial cells is temperature-sensitive. Total accumulation through the basolateral membrane is about twice that through the apical membrane. A majority of the cadmium transport in the renal cells is by diffusion. As in hepatocytes, copper, zinc and mercury antagonize cadmium transport through the apical membranes of the renal cells. The relative antagonism by copper is the same (25%); however, the antagonism by zinc (16%) and mercury (10%) is 4-to 6-fold lower than in hepatocytes. It appears that the relative contribution of various transport pathways available for cadmium uptake is different in each cell type and apparently depends on the morphological and functional differences between the cell membranes. -Environ Health Perspect 103(Suppl 1): 73-75 (1995)

show abstract

Section: Introductionmentioning

confidence: 99%

Metal transport in cells: cadmium uptake by rat hepatocytes and renal cortical epithelial cells.

Shaikh

Blazka

Endo

1995

Environ Health Perspect

View full text Add to dashboard Cite

show abstract

“…EPA, , 1986U.S. EPA, , 1988Friberg et aI.. 1974Friberg et aI.. , 1985Kjellstrom and Nordberg, 1978;Friberg, 1984;Foulkes, 1986;Fox, 1983;Tsuchiya, 1978). References were treesearched to identify additional pertinent literature.…”

Section: Data Collectionmentioning

confidence: 99%

Bioavailability of Cadmium in Food and Water: A Case Study on the Derivation of Relative Bioavailability Factors for Inorganics and Their Relevance to the Reference Dose

Ruoff

Diamond

Velazquez

et al. 1994

Regulatory Toxicology and Pharmacology

View full text Add to dashboard Cite

“…6 On the other hand, cadmium absorption may increase with calcium deficiency. 7,8 Very young organisms are at higher risk than adults at the same level of environmental exposure to cadmium, because their gastrointestinal absorption and retention are higher. The results of Kostial and co-workers 9,10 obtained in sucklings showed a very high intestinal absorption of cadmium, higher whole body retention, higher blood levels, much higher accumulation in the brain and higher oral toxicity.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of genotoxic damage of cadmium chloride in peripheral blood of suckling Wistar rats

Kašuba

Rozgaj

Sarić

et al. 2002

J of Applied Toxicology

View full text Add to dashboard Cite

The aim of this study was to evaluate possible genotoxic damage of cadmium chloride exposure in suckling rats by means of the comet assay and the in vivo micronucleus test of rat blood lymphocytes, because no information is available on the genotoxic effect of cadmium in rats at this early age. Pups were receiving cadmium (as CdCl(2).H(2)O) orally in fractions of 0.5 mg for 9 days, totalling 4.5 mg Cd kg(-1) body wt, or were given a single subcutaneous injection of 0.5 mg Cd kg(-1) body wt. Some pups in both exposed groups were receiving calcium supplement (CaHPO(4).2H(2)O) in feed to reduce the body load of cadmium. Control pups did not receive either cadmium or calcium supplement. Cadmium in the carcass and organs was measured by atomic absorption spectrometry. The results showed that the cadmium body burden was significantly lower when the animals were receiving calcium supplements along with oral cadmium. The results of the micronucleus and comet assays showed significant differences between the control and exposed groups, regardless of the route of cadmium administration. The only statistically significant difference between the two exposed groups (oral cadmium and oral cadmium + calcium supplements) was in the number of micronuclei. The results of the comet assay showed that tail length differed statistically only between the control and all exposed groups, regardless of the route of cadmium administration. It can be concluded that the applied cadmium doses caused detectable genome damage but it was lower in calcium-treated pups receiving cadmium orally.

show abstract

Absorption of Cadmium

Cited by 40 publications

References 78 publications

Metal transport in cells: cadmium uptake by rat hepatocytes and renal cortical epithelial cells.

Metal transport in cells: cadmium uptake by rat hepatocytes and renal cortical epithelial cells.

Bioavailability of Cadmium in Food and Water: A Case Study on the Derivation of Relative Bioavailability Factors for Inorganics and Their Relevance to the Reference Dose

Evaluation of genotoxic damage of cadmium chloride in peripheral blood of suckling Wistar rats

Contact Info

Product

Resources

About