Absorption of Disodium Cromoglycate from the Rat Lung: Evidence of Carrier Transport

Pulmonary Absorption Rate and Bioavailability of Drugs in Vivo in Rats: Structure–Absorption Relationships and Physicochemical Profiling of Inhaled Drugs

“…36 The transport of cromolyn in the rat lung has been reported to be mediated by an organic anion carrier. 37 However, our data indicated no active transport of the compound in the Caco-2 cell monolayers, which is in accordance with reported results from experiments in Calu-3 human bronchial epithelial cells. 10 The molecular flexibility, measured by the number of rotatable bonds, has, in addition to PSA and hydrogen bound count (HB), also been found to be an important predictor of oral bioavailability.…”

“…The data show an apparent trend for a generally higher bioavailability after pulmonary administration compared to oral administration. For instance, polar drugs [35][36][37][38]. The black marks refer to the compounds selected for the in vivo pharmacokinetic study.…”

Postnatal Development of Carrier-Mediated Absorption of Disodium Cromoglycate from the Rat Lung

“…concentrations above 25 mM, most of the DSCG absorption seen with the 50 mM solution is accounted for by simple diffusion (4). Results with 50 mM DSCG showed 30.5-46.4% absorption for rats 1-12 days of age and 18.5-23.8% absorption for rats 18 days old or older.…”

The effect of respiratory manoeuvres and pharmacological agents on the pharmacokinetics of nedocromil sodium after inhalation.

“…Probenecid will inhibit only that part of sodium cromoglycate absorption that is dependent upon active carrier-type transport (Gardiner & Schanker, 1974), and because nedocromil has almost identical pharmacokinetics it is likely that a similar mechanism exists for this drug. Both sodium cromoglycate and nedocromil are hydrophilic anions, and thus are likely to cross the respiratory mucosa through the paracellular pathway (Gumbiner, 1987), the absorptive pathway likely to be affected by stretch-induced disruption of epithelial tight junctions.…”