Absorption of doxycycline from a controlled release pellet formulation: The influence of food on bioavailability

Abstract

A three-way crossover study was performed to compare the bioavailability of a new pelletised doxycycline product administered either with food or without food and a reference product taken without food. Four different methods were used to calculate pharmacokinetic parameters from the data. The sums of squares, Akaike's Information Criterion (AIC), and the ranges for the parameters obtained were used for comparison. Good fits to the data were obtained when all four methods were used, each with a lag time. The two compartment open model was the most efficient method for describing the data. The one compartment open model was the least efficient, particularly with respect to predicting the peak concentration of doxycycline in plasma. All the models gave similar rank order results with respect to bioavailability differences between the three treatments. Analysis of the data by different methods suggests that pelletised doxycycline is bioequivalent to the reference product when taken in the absence of food. A standardized feeding regimen affected the rate, but not extent of absorption of doxycycline from the pelletised formulation.

Effects of Diet on Acne and Its Response to Treatment

“…However, in a comparative study evaluating the absorption of an extended-release formulation of minocycline under fed (high-dairy, high-fat) and fasted states, the extended-release formulation of minocycline was shown to be unaffected by stomach contents, as measured by mean area under the curve, maximum plasma concentration, and time to maximum concentration [97]. Conversely, in a three-way crossover study comparing the delayed-release formulation of doxycycline with the standard formulation, the overall rate of absorption was increased in both formulations in a fasted state compared with an unfasted state, but there was no significant difference in the overall bioavailability between the two formulations [98].…”