Absorption of drugs and other xenobiotics during development in experimental animals

Hoffmann, Helmut

doi:10.1016/0163-7258(82)90056-0

Cited by 8 publications

(3 citation statements)

References 95 publications

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“…Although it is well established that children are more susceptible than adults to the toxic effects of metal exposure (Aranda et al 1997; Fraser 1992; Johansson et al 2008; Kacew 1997; Landrigan 2004; Winder 2010), growing evidence suggests fetuses and neonates are even more vulnerable than children(Alcorn and McNamara 2002; Beath 2003; de Wildt et al 1999; Ek et al 2012; Erikson et al 2007; Fechter 1999; Gow et al 2001; Gregus et al 1998; Hakkola et al 1998; Hoffmann 1982; Juchau and Faustman-Watts 1983; Makri et al 2004; Ring et al 1999). Few epidemiologic studies examine time-resolved windows throughout development that may be more vulnerable to disrupted (excess or deficient) metal uptake.…”

Section: Discussionmentioning

confidence: 99%

Dentine biomarkers of prenatal and early childhood exposure to manganese, zinc and lead and childhood behavior

Horton

Hsu

Henn

et al. 2018

Environment International

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Section: Discussionmentioning

confidence: 99%

Dentine biomarkers of prenatal and early childhood exposure to manganese, zinc and lead and childhood behavior

Horton

Hsu

Henn

et al. 2018

Environment International

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“…Evidence also suggests that milk in the GI tract enhances absorption of certain xenobiotics and may contribute to the age differences in bioavailability (Kostial et al, 1978;NRC, 1993). Increased GI absorption in developing animals has been observed after exposure to lead (Bowers and Cohen, 1998;NRC, 1993; United States Environmental Protection Agency (U.S. EPA), 1994) polonium nitrate (Haines et al, 1993), mercuric chloride (Walsh, 1982), and for select pharmaceuticals (Hoffman, 1982;NRC, 1993).…”

Section: Discussionmentioning

confidence: 99%

Differences in Tissue Distribution of HBCD Alpha and Gamma between Adult and Developing Mice

Szabo¹,

Diliberto²,

Huwe³

et al. 2011

Toxicological Sciences

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Hexabromocyclododecane (HBCD) is a mixture of three stereoisomers alpha (α), beta (β), and gamma (γ). γ-HBCD dominates the mixture (∼70%), and despite α-HBCD's minor contribution to global HBCD production and usage (∼10%), it is the dominant congener found in most biotic samples worldwide. Evidence of toxicity and lack of stereoisomer studies drives the importance of understanding HBCD toxicokinetics in potentially susceptible populations. The majority of public health concern has focused on hazardous effects resulting from exposure of infants and young children to HBCD due to reports on adverse developmental effects in rodent studies, in combination with human exposure estimates suggesting that nursing infants and young children have the highest exposure to HBCD. This study was designed to investigate differences in the disposition of both γ-HBCD and α-HBCD in infantile mice reported to be susceptible to the HBCD commercial mixture. The tissue distribution of α-[(14)C]HBCD- and γ-[(14)C]HBCD-derived radioactivity was monitored in C57BL/6 mice following a single oral dose of either compound (3 mg/kg) after direct gavage at postnatal day 10. Mice were held up to 7 days in shoebox cages after which pups were sacrificed, tissue collected, and internal dosimetry was measured. Developing mice exposed to α-HBCD had an overall higher body burden than γ-HBCD at every time point measured; at 4 days postexposure, they retained 22% of the α-HBCD administered dose, whereas pups exposed to γ-HBCD retained 10%. Total body burden in infantile mice after exposure to γ-HBCD was increased 10-fold as compared with adults. Similarly, after exposure to α-HBCD, infantile mice contained 2.5-fold higher levels than adult. These differences lead to higher concentrations of the HBCD diastereomers at target tissues during critical windows of development. The results indicate that the toxicokinetics of the two HBCD diastereomers differ between developing and adult mice; whereas distribution patterns are similar, concentrations of each HBCD diastereomer's-derived radioactivity are higher in the pup's liver, fat, kidney, brain, blood, muscle, and lungs than in the adult's. This study suggests that developmental stage may be a risk factor for the harmful effects of α-HBCD and γ-HBCD, when developing animals may be more sensitive to effects and have increased body burden.

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“…Nevertheless, it should be recognized that age-dependent pharmacokinetic factors other than metabolism may also affect the bioavailability of DLM and the magnitude of its adverse effects. Preweanling rats are shown to have relatively high GI absorption rates (Hoffman, 1982;Naylor and Harrison, 1995). Pglycoprotein, which may play a role as an efflux transporter of pyrethroids (Bain and LeBlanc, 1996;Buss et al, 2002) has been found to be deficient in young mice (Mahmood et al, 2001).…”

Section: Age-dependent Toxic Signs Following Dlm Administrationmentioning

confidence: 99%

Ontogeny of Hepatic and Plasma Metabolism of Deltamethrin in Vitro: Role in Age-Dependent Acute Neurotoxicity

Anand¹,

Kim²,

Padilla³

et al. 2005

Drug Metab Dispos

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ABSTRACT:Deltamethrin (DLM) is a relatively potent and widely used pyrethroid insecticide. Inefficient detoxification has been proposed to be the primary reason for the greater sensitivity of immature rats to the acute neurotoxicity of DLM. The objective of this study was to test this hypothesis by characterizing the age dependence of DLM metabolism in vitro, as well as toxic signs and blood levels of the neurotoxic parent compound following administration of 10

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Absorption of drugs and other xenobiotics during development in experimental animals

Cited by 8 publications

References 95 publications

Dentine biomarkers of prenatal and early childhood exposure to manganese, zinc and lead and childhood behavior

Dentine biomarkers of prenatal and early childhood exposure to manganese, zinc and lead and childhood behavior

Differences in Tissue Distribution of HBCD Alpha and Gamma between Adult and Developing Mice

Ontogeny of Hepatic and Plasma Metabolism of Deltamethrin in Vitro: Role in Age-Dependent Acute Neurotoxicity

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