Absorption of intact morphiceptin by diisopropylfluorophosphate-treated rabbit ileum

Can the Pathophysiology of Autism be Explained by the Nature of the Discovered Urine Peptides?

“…Upper intestinal lesions related to autism have also been reported (Horvath et al, 1999;Torrente et al, 2002), and increased low molecular gut permeability in autism is known (D'Eufemia et al, 1996). It has been suggested that the latter could be due to decreased sulphation of aminoglycans in the gut (Waring and Ngong, 1993), but peptidase defects or inhibition also increases gut uptake of peptides (Mahe et al, 1989). Late onset autism could also be caused by introduction of gluten containing foods from about 6 months and onwards.…”

“…We all take up peptides (Gardner, 1994) and proteins (Husby et al, 1984;Gardner, 1994) from the gut and inhibition of peptidases increases the uptake (Mahe et al, 1989). These dietary proteins can be demonstrated in mothers' milk (Kilshaw and Cant, 1984;Troncone et al, 1987).…”

Milk protein-derived opioid receptor ligands

“…Almost ten to arrive in the cardiovascular system after gastrointestinal digestion of milk or milk products in more than years later, Renlund and colleagues 82 for the first time succeeded in demonstrating by use of chemical negligible amounts-at least not in adult animals or humans; enzymatic degradation in the intestinal wall and physical methods one of these peptides, b Hcasomorphin, (1)(2)(3)(4)(5)(6)(7)(8) in the milk from a woman with and in the blood appear to prevent it. [88][89][90] The situation looks different in newborn animals, postpartum psychosis, i.e., under in vivo conditions. i.e., presumably also in the human neonate as well Pharmacological Characteristics of Synthetic b-Casomorphin Analogues.…”

Peptides du lait à activité biologique

“…Ces résultats ont permis d'affirmer l'existence non seulement de récepteurs des~-casomorphines du côté sereux de la muqueuse intestinale, mais ils accréditent aussi l'hypothèse selon laquelle il existerait un mécanisme de régulation dont une des facettes serait la dégradation transépithéliale des fJ-casomorphines naturelles. Mahé et al (1988) ont montré que cette dégradation était principalement l'oeuvre de la dipeptidylpeptidase IV. En effet, le blocage de l'activité de cette enzyme par le di-isopropylfluorophosphate (DFP) permettait à de la morphiceptine placée du côté luminal d'une chambre de Ussing de réduire le courant de court-circuit et de stimuler l'absorption des ions Nat et CI-.…”