Absorption of the Biomimetic Chromium Cation Triaqua-Μ&lt;SUB&gt;3&lt;/SUB&gt;-oxo-Μ-hexapropionatotrichromium(III) in Rats

Clodfelder, Buffie J.; Chang, Christine; Vincent, John B.

doi:10.1385/bter:98:2:159

Cited by 59 publications

(29 citation statements)

References 26 publications

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“…Significantly higher Cr and Zn levels and lower levels of Cu were reported in the scalp hair of patients with malignant tumours than in the scalp hair of healthy donors (Kolmogorov et al 2000), evidencing that higher hair Cr and Zn contents indicated increased cancer risk. Moreover, Cr and Zn had been reported to be significantly higher in the blood of breast cancer patients as compared with healthy donors (Singh and Garg 1998), and had been significant experimental evidence that Cr stimulate oxygen radical production which induces DNA damage (Clodfelder et al 2004). Breast cancer mortality was found to be strongly contributed by Cr, followed by Cd and Zn, while for prostate cancer, Cd revealed the strongest contribution followed by Zn and Cr (Hayes 1997;Drasch et al 2005;Schrauzer 2006).…”

Section: Resultsmentioning

confidence: 99%

Comparative distribution of the scalp hair trace metal contents in the benign tumour patients and normal donors

Pasha

Malik

Iqbal³

et al. 2008

Environ Monit Assess

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The scalp hair samples of benign tumour patients (n = 77) and normal donors (n = 86) were analysed for selected trace metal contents using atomic absorption spectrophotometry. In the scalp hair of benign tumour patients, highest average levels were found for Ca (1,401 microg/g), followed by Na (476.9 microg/g), Mg (441.6 microg/g), Zn (438.3 microg/g), K (119.2 microg/g) and Fe (96.38 microg/g) while in comparison, the maximum mean levels in the scalp hair of normal donors were shown by Ca (556.5 microg/g), followed by Zn (154.2 microg/g), Mg (153.4 microg/g), Na (97.45 microg/g) and Fe (81.68 microg/g). Almost all metal levels revealed higher dispersion and asymmetry in the scalp hair of benign tumour patients compared with the normal donors. The average concentrations of Ca, Cd, Co, K, Mg, Mn, Na, Ni, Pb, Sb, Sr and Zn were significantly higher in the hair of benign tumour patients compared with the normal donors. Significant gender-based differences were also observed in the scalp hair metal contents of benign tumour patients. Strong positive correlations were found between Cd-Cr (0.547) and Cd-Co (0.507) in the hair of benign tumour patients whereas Ca-Mg, Mg-Sr, Co-Cd, Cr-Cd, Li-Cr, Li-Co, Li-Cd, Na-Cd, Na-Co and Na-Li exhibited strong relationships (r > 0.50) in the hair of normal donors. Cluster analysis (CA) and principal component analysis (PCA) were used for the source identification and apportionment of scalp hair trace metals in the two donor groups. The scalp hair of benign tumour patients and normal donors revealed six and five main clusters of trace metals, respectively. PCA extracted seven principal components of trace metals in the scalp hair of benign tumour patients while six principal components were observed in the case of normal donors. The study evidenced significantly different patterns of metal distribution in the hair of benign tumour patients in comparison with normal donors.

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Section: Resultsmentioning

confidence: 99%

Comparative distribution of the scalp hair trace metal contents in the benign tumour patients and normal donors

Pasha

Malik

Iqbal³

et al. 2008

Environ Monit Assess

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“…As noted in the present study, significantly higher Cr and Zn levels and lower levels of Cu were reported in the scalp hair of patients with malignant tumors than in the scalp hair of healthy donors [36,37], an evidence that higher hair Cr and Zn contents indicated increased cancer risk. Moreover, Cr and Zn had been reported to be significantly higher in the blood of breast cancer patients as compared with healthy donors [30], and had been significant experimental evidence that Cr stimulate oxygen radical production, which induces DNA damage [38]. Breast cancer mortality was found to be strongly contributed by Cr, followed by Cd and Zn, whereas for prostate cancer, Cd revealed the strongest contribution followed by Zn and Cr [19,21,27].…”

Section: Discussionmentioning

confidence: 99%

Characterization and Distribution of the Selected Metals in the Scalp Hair of Cancer Patients in Comparison with Normal Donors

Pasha

Malik

Iqbal

et al. 2007

Biol Trace Elem Res

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Eighteen metals were estimated in the scalp hair samples from cancer patients (n = 111) and normal donors (n = 113). Nitric acid-perchloric acid wet digestion procedure was used for the quantification of the selected metals by flame atomic absorption spectrophotometry. In the scalp hair of cancer patients, highest average levels were found for Ca (861 microg/g), followed by Na (672 microg/g), Zn (411 microg/g), Mg (348 microg/g), Fe (154 microg/g), Sr (129 microg/g), and K (116 microg/g), whereas in comparison, the dominant metals in the scalp hair of normal donors were Ca (568 microg/g), Zn (177 microg/g), Mg (154 micraog/g), Fe (110 microg/g), and Na (103 microg/g). The concentrations of Ca, Cd, Co, Cr, Fe, K, Mg, Mn, Na, Ni, Pb, Sb, Sr, and Zn were notably higher in the hair of cancer patients as compared with normal donors, which may lead to a number of physiological disorders. Strong positive correlations were found in Mn-Pb (0.83), Cd-Cr (0.82), Cd-Li (0.57), Fe-Pb (0.56), and Fe-Mn (0.55) in the hair of cancer patients whereas Na-Cd, Li-Cr, Li-Co, Co-Cd, Li-Cd, Na-Co, Na-Li, Ca-Mg and Na-Cr exhibited strong relationships (r > 0.50) in the hair of normal donors. Principal Component Analysis (PCA) of the data revealed seven PCs, both for cancer patients and normal donors, but with significantly different loadings. Cluster Analysis (CA) was also used to support the PCA results. The study evidenced significantly different pattern of metal distribution in the hair of cancer patients in comparison with normal donors. The role of trace metals in carcinogenesis was also discussed.

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“…Various complexes of trivalent Cr such as Cr-picolinate, Cr-histidinate, Cr-nicotinate, Cr-phenylalanine, and Cr-methionine have been patented and manufactured, and some of these forms have been marketed as dietary supplements worldwide [13][14][15]. However, information about their bioavailability and bioactivity in animals and humans is largely unknown.…”

Section: Introductionmentioning

confidence: 99%

“…Few studies have evaluated Cr effect on central nervous system and cognition in diabetic humans and animals. It was hypothesized that learning disability resulting from impairment in glucose metabolism and insulin action in type 2 diabetes could be ameliorated by supplemental Cr through restoring cerebral tissue Cr reserves and enhancing cerebral glucose metabolism, which may vary by its source and level [13,14]. The objective of this experiment was therefore to investigate two new organic complexes of Cr, 3 ] + NO 3 − ) on glucose metabolism and memory acquisition in a diabetic type 2 rat model induced by high-fat feeding.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Chromium Complex and Level on Glucose Metabolism and Memory Acquisition in Rats Fed High-Fat Diet

Şahin

Tuzcu

Orhan

et al. 2010

Biol Trace Elem Res

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Conditions in which glucose metabolism is impaired due to insulin resistance are associated with memory impairment. It was hypothesized that supplemental chromium (Cr) may alleviate insulin resistance in type 2 diabetes and consequently improve memory acquisition, depending upon its source and level. In a complete randomized design experiment, male Wistar rats (n=60; weighing 200-220 g) were fed either normal (8%, normal diet (ND)) or high-fat (40%, high-fat diet (HFD)) diet and supplemented with Cr as either chromium-glycinate (CrGly) or chromium-acetate (CrAc) at doses of 0, 40, or 80 μg/kg body weight (BW) via drinking water from 8 to 20 weeks of age. Feeding HFD induced type 2 diabetes, as reflected by greater glucose/insulin ratio (2.98 vs. 2.74) comparing to feeding ND. Moreover, HFD rats had greater BW (314 vs. 279 g) and less serum (53 vs. 68 μg/L) and brain (14 vs. 24 ng/g) Cr concentrations than ND rats. High-fat diet caused a 32% reduction in expressions of glucose transporters 1 and 3 (GLUTs) in brain tissue and a 27% reduction in mean percentage time spent in the target quadrant and a 38% increase in spatial memory acquisition phase (SMAP) compared with ND. Compared with supplemental Cr as CrAc, CrGly was more effective to ameliorate response variables (i.e., restoration of tissue Cr concentration, enhancement of cerebral GLUTs expressions, and reduction of the glucose/insulin ratio and SMAP) in a dose-response manner, especially in rats fed HFD. Supplemental Cr as CrGly may have therapeutic potential to enhance insulin action and alleviate memory acquisition in a dose-dependent manner, through restoring tissue Cr reserve and enhancing cerebral GLUTs expressions.

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Absorption of the Biomimetic Chromium Cation Triaqua-Μ<SUB>3</SUB>-oxo-Μ-hexapropionatotrichromium(III) in Rats

Cited by 59 publications

References 26 publications

Comparative distribution of the scalp hair trace metal contents in the benign tumour patients and normal donors

Comparative distribution of the scalp hair trace metal contents in the benign tumour patients and normal donors

Characterization and Distribution of the Selected Metals in the Scalp Hair of Cancer Patients in Comparison with Normal Donors

The Effects of Chromium Complex and Level on Glucose Metabolism and Memory Acquisition in Rats Fed High-Fat Diet

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