Absorptionsver&amp;auml;nderungen von Mangan w&amp;auml;hrend Gravidit&amp;auml;t und Laktation

Kirchgeßner, M.; Sherif, Y.S.; Schwarz, F. J.

doi:10.1159/000176549

Cited by 19 publications

(8 citation statements)

References 6 publications

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“…Previous studies have shown maternal blood Mn levels were increased during pregnancy [ 10 , 35 , 36 ]. The increase in Mn levels during pregnancy may be related to physiological factors, including increased intestinal absorption or tissue Mn mobilization [ 37 , 38 ], reflecting increased need from the fetal development. Takser et al [ 10 ] reported that blood Mn concentration in pregnant women at delivery was higher than non-pregnant women of reproductive age.…”

Section: Discussionmentioning

confidence: 99%

Maternal urinary manganese and risk of low birth weight: a case–control study

et al. 2016

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BackgroundManganese (Mn) is an essential element for humans, but exposure to high levels has been associated with adverse developmental outcomes. Early epidemiological studies evaluating the effect of Mn on fetal growth are inconsistent.MethodsWe investigated the association between maternal urinary Mn during pregnancy and the risk of low birth weight (LBW). Mn concentrations in maternal urine samples collected before delivery were measured in 816 subjects (204 LBW cases and 612 matched controls) recruited between 2012 and 2014 in Hubei Province, China.ResultsThe median Mn concentration in maternal urine was 0.69 μg/g creatinine. Compared to the medium tertile of Mn levels, an increased risk of LBW was observed for the lowest tertile (≤0.30 μg/g creatinine) [adjusted odds ratio (OR) = 1.28; 95 % confidence interval (CI) = 0.67, 2.45], and a significantly increased risk of LBW was observed for the highest tertile (≥1.16 μg/g creatinine) [adjusted OR = 2.04; 95 % CI = 1.12, 3.72]. A curvilinear relationship between maternal urinary Mn and risk of LBW was observed, showing that the concentration at 0.43 μg/g creatinine was the point of inflection. Similar associations were observed among the mothers with female infants and among the younger mothers < 28 years old. However, among the mothers with male infants or the older mothers ≥ 28 years old, only higher levels of Mn were positively associated with LBW.ConclusionsLower or higher levels of maternal urinary Mn are associated with LBW, though only the association of LBW risk and higher levels of Mn was statistically significant. The findings also show that the associations may vary by maternal age and infant sex, but require confirmation in other populations.Electronic supplementary materialThe online version of this article (doi:10.1186/s12889-016-2816-4) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Maternal urinary manganese and risk of low birth weight: a case–control study

et al. 2016

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“…This increase in blood Mn during pregnancy could be related to an increase in Mn intestinal absorption 41−43 or changes in Mn metabolism. 41 It could also result from physiological factors such as differences in tissue Mn mobilization due to increased estrogen and progesterone concentrations during pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Blood and Hair Manganese Concentrations in Pregnant Women from the Infants’ Environmental Health Study (ISA) in Costa Rica

Mora

Joode

Mergler

et al. 2014

Environ. Sci. Technol.

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Manganese (Mn), an essential nutrient, is a neurotoxicant at high concentrations. We measured Mn concentrations in repeated blood and hair samples collected from 449 pregnant women living near banana plantations with extensive aerial spraying of Mn-containing fungicide mancozeb in Costa Rica, and examined environmental and lifestyle factors associated with these biomarkers. Mean blood Mn and geometric mean hair Mn concentrations were 24.4 μg/L (8.9–56.3) and 1.8 μg/g (0.05–53.3), respectively. Blood Mn concentrations were positively associated with gestational age at sampling (β = 0.2; 95% CI: 0.1 to 0.2), number of household members (β = 0.4; 95% CI: 0.1 to 0.6), and living in a house made of permeable and difficult-to-clean materials (β = 2.6; 95% CI: 1.3 to 4.0); and inversely related to smoking (β = −3.1; 95% CI: −5.8 to −0.3). Hair Mn concentrations were inversely associated with gestational age at sampling (% change = 0.8; 95% CI: −1.6 to 0.0); and positively associated with living within 50 m of a plantation (% change = 42.1; 95% CI: 14.2 to 76.9) and Mn concentrations in drinking water (% change = 17.5; 95% CI: 12.2 to 22.8). Our findings suggest that pregnant women living near banana plantations aerially sprayed with mancozeb may be environmentally exposed to Mn.

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“…Significant increases in the mean whole blood manganese levels throughout the pregnancy period were reported previously [32,40,41] . This increase in manganese levels may be related to the enhanced absorption of manganese due to upregulation of iron absorption, particularly during the late pregnancy periods [42,43] , because mechanisms of iron absorption are similar to those of other divalent metals, particularly manganese and cadmium [4,5] . However, age-related increase in blood manganese is not observed [11] , because its absorption, disposition, and biliary excretion are actively controlled by homeostatic mechanisms as an essential element [30] .…”

Section: Manganesementioning

confidence: 99%

Sex-specific Profiles of Blood Metal Levels Associated with Metal–Iron Interactions

Lee

Kim

2014

Safety and Health at Work

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The mechanisms by which iron is absorbed are similar to those of divalent metals, particularly manganese, lead, and cadmium. These metals, however, show different toxicokinetics in relation to menarche or menopause, although their interaction with iron is the same. This review focuses on the kinetics of these three toxic metals (manganese, lead, and cadmium) in relation to menarche, pregnancy, and menopause. The iron–manganese interaction is the major factor determining sex-specific differences in blood manganese levels throughout the whole life cycle. The effects of estrogen overshadow the association between iron deficiency and increased blood lead concentrations, explaining why women, despite having lower ferritin concentrations, have lower blood lead concentrations than men. Iron deficiency is associated with elevated cadmium levels in premenopausal women, but not in postmenopausal women or men; these findings indicate that sex-specific differences in cadmium levels at older ages are not due to iron–cadmium interactions, and that further studies are required to identify the source of these differences. In summary, the potential causes of sex-specific differences in the blood levels of manganese, lead, and cadmium differ from each other, although all these three metals are associated with iron deficiency. Therefore, other factors such as estrogen effects, or absorption rate as well as iron deficiency, should be considered when addressing environmental exposure to toxic metals and sex-specific differences in the blood levels of these metals.

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Absorptionsveränderungen von Mangan während Gravidität und Laktation

Cited by 19 publications

References 6 publications

Maternal urinary manganese and risk of low birth weight: a case–control study

Maternal urinary manganese and risk of low birth weight: a case–control study

Blood and Hair Manganese Concentrations in Pregnant Women from the Infants’ Environmental Health Study (ISA) in Costa Rica

Sex-specific Profiles of Blood Metal Levels Associated with Metal–Iron Interactions

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