1991
DOI: 10.1007/bf01625409
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Abstract: S,gnal transducuon reduced by epidermal growth factor (EGF) vm ,ts receptor revolves two second messengers, chacylglycerol (DG) and momtol msphosphate, both products of phosphandylmo~to|-specdic phosphohpase C wluch seem to pamctpate m the regulauon of cellular prohferauon by EGF We observed that A431 cells and HeL~ cells m response to EGF accumulate substanual amounts of phosphauchc actd (PA), the potenual product of DG kmase However, PA appears earher and stays longer elevated than expected from DG avadabxht… Show more

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“…The activation ofphospholipase D by EGF and PMA as observed in luteal cells, has been well documented in a variety of other cells [16,17,20,21]. However, our results differ from previous observations in other cell types [22,23], where the products of phospholipase D were reported to have an inhibitory influence on adenyl-ate cyclase activity.…”
Section: Discussioncontrasting
confidence: 80%
“…The activation ofphospholipase D by EGF and PMA as observed in luteal cells, has been well documented in a variety of other cells [16,17,20,21]. However, our results differ from previous observations in other cell types [22,23], where the products of phospholipase D were reported to have an inhibitory influence on adenyl-ate cyclase activity.…”
Section: Discussioncontrasting
confidence: 80%