2020
DOI: 10.1158/1557-3265.advprecmed20-10
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Abstract 10: Precision medicine strategy to elucidate and target Bcl-2 prosurvival proteins in a wide spectrum of cancers

Abstract: Effective practice of precision medicine in oncology relies on identifying and targeting unique characteristics of individual cancers. Coupling functional analysis with genomic screening will further enhance the selection of efficacious cancer therapies. Cancer is a heterogeneous disease that is defined by distinct capabilities, one of which is the evasion of apoptosis, controlled by the antiapoptotic protein members, Bcl-2, Bcl-xL, Mcl-1, and Bfl-1. These antiapoptotic proteins have become validated therapeut… Show more

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