Abstract 1122‐000042: Demographic and Pharmacological Characteristics of Dementia Patients with Parkinson’s Disease Stratified by Gender

Abstract

Introduction : Gender differences in dementia patients and Parkinson’s Disease have been investigated extensively; however, factors that contribute to gender differences in Parkinson’s Disease with Dementia patients (PDD) is not fully understood. In this study, we tested the hypothesis that specific, demographic, and pharmacological factors may be associated with men and women patients with PDD, and contribute to gender differences. Methods : Data collected for 5 years from 7594 PDD patients was analyzed using univariate analysis to determine different factors associated with men or women with PDD. Multicollinearity interactions between independent variables in the model were examined using variance inflation factors Results : Overall, 55.22% of the PDD patients were men while 44.77% were women. In the adjusted analysis, Aripiprazole (OR = 0.581, 95% CI, 0.302‐1.118, P = 0.104), ETOH (OR = 0.371, 95% CI, 0.260‐0.531, P<0.001) African American (0.249, 95% CI, 0.088‐0.703, P = 0.009) with PD were more likely to be men. The use of Aripiprazole (OR = 0.195, 95% CI, 0.06‐0.631, P = 0.006), Escitalopram (OR = 0.651, 95% CI, 0.468‐0.906, P = 0.011), and Tobacco (OR = 0.620, 95% CI, 0.444‐0.866, P = 0.005) were associated with women. Conclusions : This study showed that women presented fewer cases of PDD than men. The current study reveals gender differences in PDD patients associated with specific demographic and pharmacological factors