Abstract 11273: Comparison of Outcome Between Type 2 versus Type 1 Myocardial Infarction: A Systematic Review and Meta-Analysis

Abstract

Introduction: Unlike type 1 myocardial infarction (T1MI) which is caused by plaque rupture and erosion, type 2 myocardial infarction (T2MI) is due to the mismatch between supply-demand of oxygen. To date, there were limited studies available and consequently, the outcomes of patients with T1MI compared to T2MI remained inconclusive. Hypothesis: We aimed to compare the outcomes of T1MI and T2MI patients in terms of mortality and adverse cardiovascular outcomes. Methods: We performed a systematic literature search of databases for relevant articles from inception until March 20, 2022. Results: 340,802 patients had T1MI while the remaining 52,855 patients had T2MI. Mean age was similar between both groups (T1MI: 69.4 years, T2MI: 71.8 years) while proportion of female was found to be more higher in T2MI (61% vs 38%). Our analysis revealed that patients with T1MI had a significantly lower odds of all-cause mortality (OR 0.44, 95%CI 0.34 to 0.56, p<0.001), in-hospital mortality (OR 0.63, 95%CI 0.46 to 0.86, p<0.001), 1-year mortality(OR 0.35, 95% CI 0.25 to 0.47, p<0.001) and MACE (OR 0.59, 95% CI 0.39 to 0.91, p=0.02). There was no significant difference in terms of 30-day mortality (OR 0.58, 95% CI 0.25 to 1.36, p=0.21), CV mortality (OR 0.95, 95% CI 0.68 to 1.32, p=0.74), all-cause readmission (OR 0.84, 95% CI 0.62 to 1.14, p=0.26) and readmission due to MI (OR 1.22, 95% CI 0.66 to 2.27, p=0.53) between both groups. Conclusions: Patients with T1MI had favourable outcomes in terms of mortality and MACE compared to that with T2MI patients. Further studies should aim at determining the optimal management strategy for these high-risk patients for better patient outcomes.