Abstract #115: What is Theoretically More Focal: HD-tDCS or TMS?

Non-invasive Brain Stimulation for the Treatment of Gilles de la Tourette Syndrome

“…In contrast to TMS, direct activation of neurons by inducing action potentials is not feasible due to low amperage ( 195 ). Compared to TMS, tDCS-effects are less focal ( 197 ) and therefore probably less specific compared to TMS. Interestingly, in a dopamine transporter-overexpressing rat model, positive evidence has been found that anodal tDCS, applied to frontal regions, diminishes repetitive behaviors via the modulation of the striato-thalamo-cortical circuit, which is known to be critically hyperactive in GTS patients ( 198 ).…”